V.F.Snegirev Archives of Obstetrics and Gynecology

Peer-review medical journal



The goal of the journal is to provide clinicians with practical information on new methods to diagnose and treat diseases of the female reproductive system as well as on the possible complications of extragenital disorders and their impact on the reproductive system.

The target audience of the journal includes not only obstetricians and gynecologists, but also endocrinologists, general practitioners, urologists, oncologists, anesthesiologists, intensive care specialists, neonatologists, pediatricians, fetal surgeons, and pharmacologists.
The journal discusses achievements in obstetrics and gynecology in Russia and the rest of the world, clinical cases, issues of terminology, diagnostics, patient management techniques, and methods of teaching obstetrics and gynecology. The journal especially focuses on the diverse effects of drugs on the female reproductive system (and other systems), the fetus, and the further development of the infant.

The journal features articles and lectures on relevant topics in obstetrics, gynecology, and allied medical fields, abstracts of important publications from other journals, and reviews of monographs. The journal also disseminates information on meetings, conferences, and symposia held in Russia and the rest of the world.


  • Russian Science Citation Index
  • Google Scholar
  • Ulrich's Periodicals directory
  • CrossRef
  • Dimensions

Types of accepted articles:

  • systematic reviews and meta-analysis;
  • results of original research;
  • plain-text reviews;
  • clinical case reports and series of clinical cases;
  • editorials;
  • datasets;
  • letters to the editor;
  • short communications.  

Publication & distribution

  • in English and Russian
  • Issues quarterly, 4 issues per year
  • Continuously publication in Online First mode
  • No APC
  • Hybrid Access: subscription and OA; Oppen Access articles distribute under the CC BY-NC-ND 4.0 License



'V.F.Snegirev Archives of Obstetrics and Gynecology' journal accepted for indexing in SCOPUS

Posted: 20.07.2023


The 'V.F.Snegirev Archives of Obstetrics and Gynecology' journal has been successfully evaluated and accepted for indexing in the SCOPUS database.

The Scopus Content Selection & Advisory Board (CSAB) has reviewed the journal and approved it for coverage. The message from CSAB was received on 11.07.2023.

Journal evaluation tracking URL: https://suggestor.step.scopus.com/progressTracker/?trackingID=0097377CA2B586FF 

All articles published in the journal from 2023 are subject for indexation.

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Current Issue

Open Access Open Access  Restricted Access Access granted  Restricted Access Subscription or Fee Access

Vol 11, No 2 (2023)

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Genetic origins of recurrent miscarriage: A review of the literature
Zaytseva N.I., Revina D.B., Shcherbakova L.N., Panina O.B.

Currently, recurrent miscarriage is considered a polygenic multifactorial disease, that is, a condition in which the predisposition to miscarriage is related to various genetic factors. The realization of these factors depends largely on the environment. This paper analyzes the current world literature on the effect of single-nucleotide polymorphisms of genes associated with recurrent miscarriage. The literature review summarized data from recent meta-analyses regarding the association between recurrent miscarriage and genetic polymorphisms leading to endothelial dysfunction (vascular endothelial growth factor A gene and endothelial NO synthase genes), hereditary thrombophilia (Leiden mutation and polymorphisms in the methylene tetrahydrofolate reductase gene), immunological disorders (cytokine genes, including interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha), altered receptor interactions in the endometrium (progesterone receptor and ESR1 and ESR2 estrogen receptor genes), and imbalance between lipoproteins of different densities (apolipoprotein E gene). The study of genetic predisposition to miscarriage is necessary to identify high-risk cases, initiate timely and careful monitoring, and develop personalized preventive techniques.

V.F.Snegirev Archives of Obstetrics and Gynecology. 2023;11(2):85-94
pages 85-94 views
Iron deficiency and ferroptosis in gynecology. Possible corrections: A review of the literature
Ozolinya L.A., Mamedli S.E., Bakhodurova K.A.

The review presents the main aspects of iron deficiency anemia (IDA) in women of reproductive age and highlights current diagnostic methods, therapy, and prevention of IDA. Moreover, the paper presents contemporary views on the molecular mechanisms of iron metabolism and iron homeostasis disruption involved in endometriosis. The role of laboratory tests in the diagnosis of latent and symptomatic iron deficiency of extreme importance was also described. In addition to IDA, anemia also occurs in patients with chronic gynecological diseases with a different pathogenesis. Its mechanisms were reported in the study discussed in the review. The results of the study on ferroptosis in patients with endometriosis were demonstrated, which showed significantly levels of iron, ferritin, lipid hydroperoxide, and low-density lipoprotein were higher in the peritoneal fluid of women with endometriosis than in healthy women. The paper provided current information on the treatment of IDA in gynecology, possible symptomatic hypophosphatemia after intravenous therapy with iron-containing drugs, and methods to treat this complication. Current data on ferroptosis, its effect on the body, and ways of inducing, and inhibiting this process were presented.

V.F.Snegirev Archives of Obstetrics and Gynecology. 2023;11(2):95-103
pages 95-103 views

Original articles

Results of surgical treatment of polycystic ovarian syndrome in women of reproductive age
Sosnova E.A., Gracheva T.S.

BACKGROUND: Polycystic ovarian syndrome (PCOS) is one of the most common and to some extent mysterious diseases falling under the competence of gynecologists. PCOS occurs in 5–10% of women of reproductive age. This paper presented the long-term results of surgical treatment of patients with PCOS.

AIM: This study aimed to determine the efficiency of surgical treatment of the ovaries to restore reproductive function in women with PCOS.

MATERIALS AND METHODS: The initial diagnosis of PCOS was made at the outpatient examination. The study included 121 women of reproductive age diagnosed with PCOS when other factors of infertility and menstrual dysfunction were excluded. Patients with PCOS as an initial diagnosis for hospitalization and absence of tubal-peritoneal infertility and male infertility were included. All patients (n = 121) underwent surgical treatment and histological examination. Patients were referred for treatment to gynecological surgical hospitals. In particular, 54 (group 1), 48 (group 2), and 19 (group 3) women were treated in a municipal clinical hospital, research center, and commercial clinic, respectively. Statistical data analysis was performed with the STATISTICA Base software package using parametric and nonparametric methods. Arithmetic mean, standard deviations, medians, and percentiles of the indices were calculated. Confidence limits to the arithmetic mean were calculated based on Student’s distribution. The exact 95% confidence limits to frequencies and the reliability of differences in frequencies between the groups were determined using binomial distribution and the chi-square test, respectively. In addition, the Mann–Whitney (U) and Wilcoxon nonparametric tests were used because several indicators had significantly normal distributions. Differences were considered statistically significant at p <0.05.

RESULTS: Of the total number of patients (n = 121), 108 (89%) became pregnant postoperatively, and 13 (11%) did not. Moreover, 47 (39%) of the total number of patients became pregnant for up to 1 year and 61 (50%) for over a year, and 48 (39.6%) of 108 patients became pregnant post-in vitro fertilization (IVF, 1–2 attempts in 37 (32%) and more than 3 attempts in 11, or 9% patients). PCOS was confirmed in 6 (14%) patients; of these, spontaneous pregnancy occurred in 5 (83%), including 4 patients in the first year and 1 in over a year. These patients had clinical and biochemical signs of hyperandrogenism and insulin resistance.

PCOS-like conditions were diagnosed in 37 (86%) patients; of these, pregnancy occurred in 33 (89%), including spontaneous pregnancy in 10, or 27% (4 within 1 year and 6 over 1 year) patients. Post-IVF pregnancy was diagnosed in 23 (62%) patients (1–2 attempts in 20, or 54.1%, and more than 3 attempts in 3, or 8.1% women).

CONCLUSIONS: Surgical treatment of patients with PCOS is an independent treatment of this gynecological and metabolically burdened disease. This method has both indications and contraindications, and it has specific types, which require certain patient preparations, such as weight loss, blood glucose control, hyperinsulinemia analysis, and compensation of arterial hypertension, to increase treatment efficiency.

V.F.Snegirev Archives of Obstetrics and Gynecology. 2023;11(2):105-111
pages 105-111 views
Laparoscopic correction of combined forms of genital prolapse
Bryunin D.V., Chushkov Y.V., Pyatkina A.N.

BACKGROUND: The significance of pelvic organ prolapse is determined by the absence of a downward trend in its frequency and severity and by the steadily high number of recurrences in every third woman who underwent surgery. According to most authors, surgical correction is the primary treatment for genital prolapse. Therefore, the search for an effective and safe surgical treatment of this pathology is important. Currently, various minimally invasive surgical interventions have been performed via laparoscopic access, which reduces the risk of tissue or adjacent organ damage, possible intraoperative bleeding, and potential complications.

AIM: This study aimed to assess the efficiency and safety of laparoscopic techniques for the correction of genital prolapse.

MATERIALS AND METHODS: The study included 12 patients with pelvic organ prolapse quantification system grades II–IV who underwent surgical correction using a combined laparoscopic approach. The inclusion criterion was the presence of prolapse, including recurrent forms. At the outpatient stage, the patients’ medical history was collected, and complaints, and degree of pelvic organ prolapse were assessed. Genital prolapse was diagnosed based on medical history, clinical data, and additional methods of examination.

RESULTS: With this surgical intervention technique, intraoperative bleeding was avoided, the number of possible postoperative complications was reduced, and disease recurrence was prevented. The criteria for assessing the surgical intervention included improvement of the pelvic floor anatomy, elimination of symptoms, patient’s satisfaction with treatment results and quality of life, and reduced risk of recurrence of complications. Mesh-associated complications were excluded by avoiding contact of the synthetic implanted material with the vaginal mucosa.

CONCLUSIONS: Through laparoscopic access, the length of hospital stay was reduced, and compared with abdominal access, a better cosmetic effect was achieved. A comprehensive system considering the assessment of the anatomical outcome, functional status of the pelvic floor, and patient’s quality of life may become the most objective tool to evaluate the success of surgical treatment of genital prolapse.

V.F.Snegirev Archives of Obstetrics and Gynecology. 2023;11(2):113-122
pages 113-122 views
Cervical carcinogenesis associated with the use of combined oral contraceptives: is there a relationship?
Klyukina L.A., Sosnova E.A., Ishchenko A.A., Davydov M.M.

BACKGROUND: Cervical cancer is one of the leading cancers in women of reproductive age. The etiological role of the human papillomavirus (HPV) in cancer development is long known and undisputed. However, owing to the widespread use of combined oral contraceptives (COCs), scientists actively investigate possible mechanisms of interrelation between sex steroids and HPV in terms of cervical cancer risk.

AIM: This study aimed to assess the risk of cervical cancer in women of reproductive age, depending on the use of COCs for different durations.

MATERIALS AND METHODS: The study included 411 patients of reproductive age who were treated at the Center for Gynecology and Reproductive Technologies of the Russian Ministry of Health and the Department of Oncogynecology at the University Clinical Hospital No. 4 of the I.M. Sechenov First Moscow State Medical University between January 2015 and December 2021. All patients were divided into two groups. The study group included 291 patients with verified cervical cancer, and the control group included 120 patients without cancer.

RESULTS: The study group was significantly more likely to take COCs (56, or 19.2%) than the control group (11, or 6.5%; p=0.018). In addition, the study group had significantly longer treatment durations (p=0.011). Overweight (n = 52, or 17.9%) and grade II obesity (n = 11, or 3.8%, vs. 0; p=0.03) were significantly more common in the study group than in the control group (n = 8, or 4.7%; p=0.003). The result of the multivariate analysis showed that taking COCs negatively affect cervical cancer development (p=0.018; odds ratio (OR) 1.230; CI 1.064–1.423). The receiver operating characteristic analysis revealed that the use of COCs has a high predictive value for determining the risk of cervical cancer (area under the curve, AUC=0.742); the sensitivity and specificity of this predictor were 74.07% and 72.73%, respectively. In the assessment on the effect of duration of COC use on the risk of cervical cancer, the results showed that total use of COCs for over 7 years was associated with a higher risk of cervical cancer development (p=0.010; OR 1.68; CI 1.1–2.5).

CONCLUSIONS: Prescribing COCs in patients with HPV infection requires a personalized approach to consider etiologic factors of cervical cancer and reduce possible carcinogenic risks.

V.F.Snegirev Archives of Obstetrics and Gynecology. 2023;11(2):123-132
pages 123-132 views
Oxidative Metabolism Genes in Ovarian Neoplasms
Proskurnina E.V., Fedorova M.V., Savinova E.A., Voznesenskii V.I., Kostyuk S.V., Sosnova E.A.

BACKGROUND: Reactive oxygen species play important and ambiguous role in carcinogenesis, and local oxidative metabolism may differ significantly from systemic metabolism and determine the processes occurring in tumor tissues.

AIM: This study aimed to examine the expressions of key oxidative metabolism genes, particularly CYB5R, POR, NOX4, SOD1, NFB, and NRF2, in ovarian neoplasm tissues, and determine cytochrome b5 reductase and cytochrome P450 reductase activity, blood neutrophil activity, and antioxidant indices in the blood plasma and peritoneal fluid.

MATERIALS AND METHODS: The study included two groups of patients: a study group (n = 10) with ovarian adenocarcinoma and a comparison group (n = 6) with benign ovarian neoplasms. The expressions of CYB5R1, CYB5R2/R4, CYB5R3, POR, BIRC3, NOX4, NRF2, NFB, SOD1, HMOX1, and BCL2 genes, cytochrome b5 reductase, and cytochrome P450 reductase activity, oxidative activity of blood neutrophils, and antioxidant potential of plasma and peritoneal fluid were evaluated in these two groups of women.

RESULTS: The expression levels of CYB5R3 and BCL2 were significantly lower in adenocarcinoma tissues. The activities of cytochrome b5 reductase and cytochrome P450 reductase increased in the group with adenocarcinoma. On average, the activity of blood neutrophils corresponded to the reference values. For blood plasma, the antioxidant capacity were not different, whereas the antioxidant capacity in the peritoneal fluid increased approximately twofold in ovarian cancer.

CONCLUSIONS: Significantly increased cytochrome b5 reductase activity in adenocarcinoma tissues may be a response to intracellular oxidative stress, whereas CYB5R3 gene expression may be reduced by a negative feedback mechanism. The activities of cytochrome P450 reductase and its gene change to a lesser extent in the presence of ovarian adenocarcinoma. The oxidative balance in the blood and peritoneal fluid correlated with the tissue expressions of NFB and NRF2.

V.F.Snegirev Archives of Obstetrics and Gynecology. 2023;11(2):133-143
pages 133-143 views
Peculiarities of contraceptive behavior among female medical students
Ogaderova N.A., Svidinskaya E.A., Ageev M.B., Sosnova E.A.

BACKGROUND: This paper presents a review of the current literature on reproductive health problems and contraception in Russian girls. The history of the development and use of contraception in our country was considered, and the awareness, and choice of a suitable method of protection against unwanted pregnancies among Russian university students were analyzed. In addition, data on the contraceptive preferences of students in Europe, Asia, and United States were presented. The MEDLINE, Global Health, CyberLeninka, RSCI, and databases were searched for papers. Moreover, this review presents the results of the authors’ study aimed at determining the contraception methods preferred by third- and fifth-year female students of the I.M. Sechenov First Moscow State Medical University (Sechenov University) and assessing the level of awareness on pregnancy planning.

MATERIALS AND METHODS: An anonymous online questionnaire was administered to third- and fifth-year girls at Sechenov University. A total of 360 questionnaires (filled out on the Yandex.Forms platform) administered to female students aged 19–24 years were analyzed.

RESULTS: The questionnaires of 176 third- and 184 fifth-year female students were evaluated. The majority of the third-year (72.2%) and fifth-year (83.8%) students had sexual experiences. The main contraception methods among third- and fifth-year female students were barrier methods and interrupted intercourse, hormonal methods of contraception were rarely used (up to 10% of the respondents), and no experience in using intrauterine contraceptives and spermicides was reported.

CONCLUSIONS: The lack of awareness among medical students on modern and reliable contraception methods and their preference for ineffective methods indicate the need to cover reproductive health issues from the first year of study.

V.F.Snegirev Archives of Obstetrics and Gynecology. 2023;11(2):145-154
pages 145-154 views

Clinical Practice Guidelines

Blood transfusion problems in the clinical recommendations “Extrauterine (ectopic) pregnancy”
Pokhabov D.S., Zhiburt E.B.

BACKGROUND: This study aimed to assess compliance to transfusion therapy recommendations in the clinical guidelines “Extrauterine (ectopic) pregnancy” with blood transfusion standards and the achievements of evidence-based medicine in transfusiology.

THE MAIN PART: The study assessed the compliance to recommendations on transfusion therapy in the clinical guidelines “Extrauterine (ectopic) pregnancy ― 2021–2022–2023 (01.07.2021)” with blood transfusion guidelines approved by the Russian Ministry of Health (laws, governmental decrees, orders of the Russian Ministry of Health, and instructions on medicines, and medical devices).

It was found that the issues of blood transfusion in the clinical recommendations “Ectopic (ectopic) pregnancy ― 2021–2022–2023 (01.07.2021)” need correction on the following points:

  • replace the names of obsolete blood components with current ones;
  • replace obsolete blood components with modern ones;
  • provide recommendations on immunohematological examination of the recipient and selection of compatible blood components;
  • exclude recommendations to use the cancelled “regulatory guillotine” orders of the the Ministry of Health of Russia;
  • replace the term “factor VIII concentrate” with “cryoprecipitate” and use fibrinogen concentration rather than factor VIII activity to monitor the efficiency of cryoprecipitate;
  • when describing a massive transfusion protocol, clarify that four units must be pooled to obtain a therapeutic dose of platelets, and five units extracted from a dose of whole blood must be pooled to obtain a therapeutic dose of cryoprecipitate;
  • bring the recommendations in accordance with the instructions for the medical use of prothrombin complex concentrate and eptacog alfa activated;
  • remove the recommendation to use fibrinogen concentrates not registered in Russia.

CONCLUSIONS: Precise recommendations for blood transfusion will improve the treatment of patients with ectopic pregnancy.

V.F.Snegirev Archives of Obstetrics and Gynecology. 2023;11(2):155-160
pages 155-160 views


Pregnancy and delivery after lumbosacral junction fixation: A clinical observation
Androsova Y.Y., Petrukhin V.A., Akhvlediani K.N., Kolesov S.V., Kazmin A.I., Lubnin A.Y., Zakirov B.A., Mel’nikov A.P., Travkina A.A., Petrov P.A.

The clinical signs of spondylolysis and spondylolisthesis most commonly appear at a young age in professional athletes and ballet dancers. The development and improvement of diagnostic methods and surgical treatment techniques for these pathologies lead to an increase in the number of patients of reproductive age with implants in the lumbosacral junction. A multidisciplinary approach in the management of pregnancy and determination of the delivery method in women with this pathology allows for safe reduction in the incidence of unwarranted operative delivery without worsening maternal and perinatal outcomes. This study presents the clinical case of a patient who had surgery for spondylolysis and spondylolisthesis and delivered successfully through natural childbirth at full-term gestation.

V.F.Snegirev Archives of Obstetrics and Gynecology. 2023;11(2):161-168
pages 161-168 views

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