Email this article The importance of brain natriuretic peptide in assessing fetal condition and predicting perinatal outcomes in pregnant women with preeclampsia
- Authors: Timokhina E.1, Ignatko I.1, Grigoryan I.1, Sarakhova D.K.2, Fedyunina I.2, Bogomazova I.2, Pesegova S.2, Seurko K.2, Melek M.2, Cherkashina A.2
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Affiliations:
- I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
- Maternity hospital of GBUZ "GKB named after S.S. Yudin DZM", Moscow, Russian Federation
- Section: Original study articles
- Submitted: 13.11.2024
- Accepted: 08.02.2025
- Published: 11.04.2025
- URL: https://archivog.com/2313-8726/article/view/641833
- DOI: https://doi.org/10.17816/aog641833
- ID: 641833
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Abstract
BACKGROUND: Fetal health assessment and prediction of perinatal outcomes in pregnant women with preeclampsia (PE) is an urgent task of modern obstetrics. The management of pregnant women with PE and fetal growth restriction (FGR) is based mainly on the use of instrumental research methods, however, an additional marker that allows predicting the aggravation of this complication of pregnancy, deterioration of the fetus, is extremely relevant.
AIM: to determine the value of cerebral natriuretic peptide (BNP) in predicting perinatal outcomes in patients with PE.
METHODS: In order to improve perinatal outcomes, reduce infant morbidity and mortality, we conducted a prospective study of 110 patients at 22-40 weeks gestation. The main group consisted of 80 patients with an established diagnosis of PE. Two subgroups were identified: patients with FGR and impaired blood flow in the fetal umbilical cord artery (AU) - 40 (50%) pregnant women, and patients with PE but without FGR - 40 (50%). The control group consisted of 30 patients with uncomplicated pregnancy. Duration of the study: November 2022 - July 2024. The level of BNP was determined in blood serum by electrochemiluminescent immunoassay. Blood flow measurements in the mother-placenta-fetus system were performed at the time of admission to the hospital using a Siemens ultrasound machine.
RESULTS: All patients completed the study. A statistical significance was revealed between high BNP levels and the development of FGR and impaired blood flow in the fetal umbilical cord artery (AU), (P<0.001). In the subgroup with FGR and impaired AP, the BNP level was significantly higher compared to the subgroup without FGR (227.25 and 79.5 pg/ml accordingly).
CONCLUSION: In the presented study, we showed that the level of BNP in patients with FGR and impaired fetal blood flow exceeds the standard values by 2.8 times than in patients without FGR, which confirms the role of maladaptation of the «mother-placenta-fetus» system in PE. We have determined a threshold value predicting the development of AF and/or impaired blood flow in the AU.
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About the authors
Elena Timokhina
I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Email: timokhina_e_v@staff.sechenov.ru
ORCID iD: 0000-0001-6628-0023
MD, Dr Sci Med, Professor of the Department of Obstetrics, Gynecology and Perinatology, Institute of Clinical Medicine, Sechenov University
Russian Federation, Bolshaya Pirogovskaya str., 2, build. 4, Moscow, Russia, 119435Irina Ignatko
I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Email: ignatko_i_v@staff.sechenov.ru
ORCID iD: 0000-0002-9945-3848
SPIN-code: 8073-1817
MD, Dr Sci Med, Corresponding Member of RAS, Head of the Department of Obstetrics, Gynecology and Perinatology, Institute of Clinical Medicine, Sechenov University
Russian Federation, Bolshaya Pirogovskaya str., 2, build. 4, Moscow, Russia, 119435Irina Grigoryan
Email: irina_grss@mail.ru
ORCID iD: 0000-0001-6994-0090
SPIN-code: 9037-2433
MD, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatology, Institute of Clinical Medicine, Sechenov University
Dzhamilia Khazhbarovna Sarakhova
Maternity hospital of GBUZ "GKB named after S.S. Yudin DZM", Moscow, Russian Federation
Author for correspondence.
Email: dzh2010@yandex.ru
ORCID iD: 0009-0008-0531-0899
Cand. Sci. (Med.), Deputy Chief Physician for Obstetric and Gynecological care, Maternity Hospital of GBUZ «State Clinical Hospital named after S.S. Yudin DZM»;
Irina Fedyunina
Email: fedyunina_i_a@staff.sechenov.ru
ORCID iD: 0000-0002-9661-5338
Irina Bogomazova
Email: bogomazova_i_m@staff.sechenov.ru
ORCID iD: 0000-0003-1156-7726
Svetlana Pesegova
Email: pesegova_s_v@staff.sechenov.ru
ORCID iD: 0000-0002-1339-5422
Ksenia Seurko
Email: kseurko@yandex.ru
ORCID iD: 0009-0001-3287-9254
Mila Melek
Email: melek15293@gmail.com
ORCID iD: 0009-0004-7316-2702
Anna Cherkashina
Email: cherkashina_a_v@student.sechenov.ru
ORCID iD: 0000-0002-3840-1948
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