Impact of bariatric surgery on reproductive health in women with obesity
- Authors: Pak A.S.1, Khudyakova V.A.1, Svidinskaya E.A.1, Sosnova E.A.1
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Affiliations:
- I.M. Sechenov First Moscow State Medical University
- Issue: Vol 12, No 2 (2025)
- Pages: 140-150
- Section: Reviews
- Submitted: 21.10.2024
- Accepted: 11.12.2024
- Published: 10.06.2025
- URL: https://archivog.com/2313-8726/article/view/637306
- DOI: https://doi.org/10.17816/aog637306
- EDN: https://elibrary.ru/ARPMCW
- ID: 637306
Cite item
Abstract
The issue of obesity remains highly relevant both in Russia and worldwide, becoming increasingly acute each year. Bariatric surgery in women with obesity is associated with a number of positive effects, including improved fertility, a reduced risk of gestational diabetes and pre-eclampsia due to enhanced insulin sensitivity and normalization of glucose levels. However, the intrapartum and postpartum periods are associated with several challenges, including an increased risk of micronutrient deficiencies, development of dumping syndrome, anemia, and fetal growth retardation. Therefore, it is essential to develop individualized treatment plans for patients following bariatric surgery to prevent potential complications affecting both the mother and the fetus. Special attention should be paid to additional vitamin intake and individualized dietary planning, as these are important for the future child's health. Bariatric surgery is an effective treatment for obesity, but it should only be recommended when conservative approaches—such as dietary and lifestyle modifications, pharmacotherapy, and increased physical activity—fail to achieve sufficient weight loss. When choosing this method of obesity treatment, women should be informed about possible complications, postoperative metabolic peculiarities, and the necessity of their correction. It is also important to inform patients about postoperative rehabilitation and preconception care, which should last 12–18 months after surgery before planning a pregnancy. This review was based on a search in the PubMed database using the logical operator and a combination of the following keywords: pregnancy and bariatric procedures. This search yielded 111 results, 50 of which were relevant to the study topic. The types of publications included: article type, books and documents, clinical trial, meta-analysis, randomized controlled trial, review, and systematic review. An additional publication search was conducted using the eLibrary and PubMed databases, focusing on the following keywords: ожирение и репродуктивная система (obesity and reproductive system), ожирение и бесплодие (obesity and infertility), бариатрическая хирургия (bariatric surgery), осложнения бариатрической операции (bariatric surgery complications), морбидное ожирение (morbid obesity), and беременность после бариатрической операции (pregnancy after bariatric surgery). The review includes articles published over the past 10 years.
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About the authors
Angelina S. Pak
I.M. Sechenov First Moscow State Medical University
Email: angelina.pak-02@mail.ru
ORCID iD: 0009-0004-4494-7316
Russian Federation, Moscow
Valeria A. Khudyakova
I.M. Sechenov First Moscow State Medical University
Email: lerrra3105@mail.ru
ORCID iD: 0009-0000-4239-240X
Russian Federation, Moscow
Evgenia A. Svidinskaya
I.M. Sechenov First Moscow State Medical University
Author for correspondence.
Email: svidinskaya@gmail.com
ORCID iD: 0000-0002-2368-1932
SPIN-code: 3002-6388
MD, Cand. Sci. (Medicine), Assistant Lecturer
Russian Federation, MoscowElena A. Sosnova
I.M. Sechenov First Moscow State Medical University
Email: sosnova-elena@inbox.ru
ORCID iD: 0000-0002-1732-6870
SPIN-code: 6313-9959
MD, Dr. Sci. (Medicine), Professor
Russian Federation, MoscowReferences
- NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;403(10431):1027–1050. doi: 10.1016/S0140-6736(23)02750-2
- Russian Statistical Yearbook. 2023: Stat.sat./Rosstat. Moscow; 2023. 701 p. URL: http://ssl.rosstat.gov.ru/storage/mediabank/Ejegod_2023.htm
- Kaschenko VA, Strizheletsky VV, Neimark AE, et al. Bariatric surgery. St. Petersburg; 2020. 48 р. ISBN: 978-5-905149-34-4 (In Russ.)
- Demidova TYu, Gritskevich EYu. Role of obesity in development of reproductive disorders and possibilities of risk management. RMJ. 2018;26(11-2):105–109. EDN: YOCINV
- Artemenko YuS, Khamoshina MB, Ryabova VA, Zyukina Z.V. Obesity in women: current aspects of reproductive health disorders. Medical Council. 2022;16(5):32–39. doi: 10.21518/2079-701X-2022-16-5-32-39 EDN: AYYHMS
- Moradi R, Kashanian M, Mokhber S, Pazouki A. Pregnancy following metabolic-bariatric surgery in a woman with potential premature ovarian failure: a case report. Case Rep Surg. 2024;2024:4707627. doi: 10.1155/2024/4707627
- Akhmedova ShU, Sadykova DSh. The menstrual disorders in women of reproductive age with obesity. Miznarodnij Endokrinologicnij Zurnal. 2015;(8):78–82. doi: 10.22141/2224-0721.8.72.2015.72343 EDN: VUWSOT
- Shatursunova MA, Murodkhuzhaev SB, Ibragimov ZhN. Metabolic syndrome, menstrual cycle disorder in women with grade III obesity. Experimental and Clinical Gastroenterology Journal. 2016;(2):100. (In Russ.) EDN: VVISZL
- Kongkit J, Charoenvidhya D, Udomsawaengsup S, Boonchaya-Anant P. Immediate return of fertility function following a bariatric surgery: A case report. J Obstet Gynaecol Res. 2019;45(10):2111–2115. doi: 10.1111/jog.14077
- Yudin VA, Melnikov AA, Usachev IA, et al. The management of pregnancy in female patient having bariatric operation. Lechenie i profilaktika. 2016;(2):51–54. EDN: WEAYJP
- Tachkova OA, Artymuk NV, Suturina LV. Pregnancy and delivery after surgical treatment of obesity. Fundamental and Clinical Medicine. 201;3(3):97–100. EDN: YKWQFV
- Pg Baharuddin DM, Payus AO, Abdel Malek Fahmy EH, et al. Bariatric surgery and its impact on fertility, pregnancy and its outcome: A narrative review. Ann Med Surg (Lond). 2021;72:103038. doi: 10.1016/j.amsu.2021.103038
- Chang C, Chang S, Poles J, Popov V. The impact of bariatric surgery compared to metformin therapy on pregnancy outcomes in patients with polycystic ovarian syndrome: a systematic review and meta-analysis. J Gastrointest Surg. 2021;25(2):378–386. doi: 10.1007/s11605-020-04900-3
- Charalampakis V, Tahrani AA, Helmy A, et al. Polycystic ovary syndrome and endometrial hyperplasia: an overview of the role of bariatric surgery in female fertility. Eur J Obstet Gynecol Reprod Biol. 2016;207:220–226. doi: 10.1016/j.ejogrb.2016.10.001
- Kruchinin EV, Аutlev KM, Smetanin EI, et al. Reproductive functions in patients with exessive obesity after bariatric surgery. Medical Science and Education of Ural. 2020;21(1):22–25. EDN: SUHVRT
- Dora SV, Shvets ZV, Semikova GV, et al. The effect of bariatric surgery on ovarian reserve in obese patients with primary infertility. Doktor.Ru. 2024;23(4):73–78. doi: 10.31550/1727-2378-2024-23-4-73-78 EDN: ENSJRP
- Huluță I, Apostol LM, Botezatu R, et al. Beyond weight loss: a comprehensive review of pregnancy management following bariatric procedures. Medicina (Kaunas). 2024;60(4):635. doi: 10.3390/medicina60040635
- Kjær MM, Torvin-Andersen LL, Dam P, et al. Pregnancy after bariatric surgery. Ugeskr Laeger. 2017;179(49):V05170349.
- Law S, Wan K, Yang W. Effects of bariatric surgery on sexual function and fertility: A narrative review. Obes Rev. 2024;25(8):e13757. doi: 10.1111/obr.13757
- Akhter Z, Rankin J, Ceulemans D, et al. Pregnancy after bariatric surgery and adverse perinatal outcomes: A systematic review and meta-analysis. PLoS Med. 2019;16(8):e1002866. doi: 10.1371/journal.pmed.1002866
- Narayanan RP, Syed AA. Pregnancy following bariatric surgery-medical complications and management. Obes Surg. 2016;26(10):2523–2529. doi: 10.1007/s11695-016-2294-x
- Mazurina NV, Ogneva NA, Troshina EA, et al. Abnormal calcium metabolism in the remote period after bariatric surgery. Experimental and Clinical Gastroenterology Journal. 2013;(12):27–32. EDN: SZUUGZ
- Snoek KM, Steegers-Theunissen RPM Hazebroek EJ, et al. The effects of bariatric surgery on periconception maternal health: a systematic review and meta-analysis. Hum Reprod Update. 2021;27(6):1030–1055. doi: 10.1093/humupd/dmab022
- Pathak MM, Shekhar KV, Meshram RJ. A narrative review on effects of maternal bariatric surgery on offspring. Cureus. 2023;15(11):e48513. doi: 10.7759/cureus.48513
- Sherf-Dagan S, Goldenshluger A, Azran C, et al. Vitamin K-what is known regarding bariatric surgery patients: a systematic review. Surg Obes Relat Dis. 2019;15(8):1402–1413. doi: 10.1016/j.soard.2019.05.031
- Karimi Behnagh A, Eghbali M, Abdolmaleki F, et al. Pre- and postsurgical prevalence of thiamine deficiency in patients undergoing bariatric surgery: a systematic review and meta-analysis. Obes Surg. 2024;34(2):653–665. doi: 10.1007/s11695-023-06896-6
- Różańska-Walędziak A, Walędziak M, Mierzejewska A, et al. Nutritional implications of bariatric surgery on pregnancy management — a narrative review of the literature. Medicina (Kaunas). 2023;59(10):1864. doi: 10.3390/medicina59101864
- Mahawar KK. Pregnancy and bariatric surgery. Minerva Chir. 2017;72(6):538–545. doi: 10.23736/S0026-4733.17.07421-1
- Gasmi A, Bjørklund G, Mujawdiya PK, et al. Dietary supplements and bariatric surgery. Crit Rev Food Sci Nutr. 2023;63(25):7477–7488. doi: 10.1080/10408398.2022.2046542
- Bąk-Sosnowska M, Naworska B. Medical and psychological aspects of pregnancy in women with obesity and after bariatric surgery. Nutrients. 2023;15(19):4289. doi: 10.3390/nu15194289
- Mokhlesi SS, Vasilevski V, Sweet L. Breastfeeding and pre-pregnancy bariatric surgery: A scoping review. Women Birth. 2024;37(3):101600. doi: 10.1016/j.wombi.2024.101600
- Abdou AM, Wasfy MA, Negm M, et al. Pregnancy after bariatric surgeries; best timing, gestational, and neonatal outcomes. Middle East Fertil Soc J. 2023;28:7. doi: 10.1186/s43043-023-00133-x
- Chigisheva EH, Batyrshin II, Sarvalieva AF, et al. The impact of bariatric surgery on female reproductive health. Obstetrics, Gynecology and Reproduction. 2024;18(2):254–267. doi: 10.17749/2313-7347/ob.gyn.rep.2024.485 EDN: BNVBXQ
- Kaliyeva DK, Slobodchikova TS, Evgenyeva IA, et al. Pregnancy after bariatric operation — gastrybypass. Medicine and Ecology. 2019;(3):91–93. EDN: REALKJ
- Kruchinin EV. Clinico-metabolic substantiation of the choice of bariatric surgery in patients with morbid obesity [dissertation abstract]. Tyumen; 2017. 22 р. EDN: ZQFINR
- Vynckier AK, Ceulemans D, Vanheule G, et al. Periconceptional folate supplementation in women after bariatric surgery-a narrative review. Nutrients. 2021;13(5):1557. doi: 10.3390/nu13051557
- Furness D, Fenech M, Dekker G, et al. Folate, vitamin B12, vitamin B6 and homocysteine: impact on pregnancy outcome. Matern Child Nutr. 2013;9(2):155–166. doi: 10.1111/j.1740-8709.2011.00364.x
- Willis K, Lieberman N, Sheiner E. Pregnancy and neonatal outcome after bariatric surgery. Best Pract Res Clin Obstet Gynaecol. 2015;29(1):133–144. doi: 10.1016/j.bpobgyn.2014.04.015
- González I, Lecube A, Rubio M.Á, García-Luna PP. Pregnancy after bariatric surgery: improving outcomes for mother and child. Int J Womens Health. 2016;8:721–729. doi: 10.2147/IJWH.S99970
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