Vol 3, No 4 (2016)

Pregnancy represents the procoagulant state, giving rise in the high prevalence rate of thrombotic complications. An imbalance between coagulation and anticoagulation systems of blood during pregnancy can lead to the development of pre-eclampsia, intrauterine growth retardation, preterm labor, premature rupture offetal membranes and fetal death. These complications are mostly caused by the impaired generation of thrombin as well as changes in the concentration and activity of tissue factor TFPI (tissue factor pathway inhibitor), TAT III complex and protein Z. Nevertheless, it should be noted that the thrombotic complications during pregnancy depend not on the elevation of the concentrations of specific coagulation factors or lack of the activity of anticoagulant proteins, but on the shift in the whole system toward the procoagulant state. These disorders most of all lead to thromboses ofplacental vessels, causing disorders ofperfusion of the affected area. Placental pathology can develop as from the maternal as from the fetal side. Despite the fact that changes in the blood coagulation system occur from the very beginning of pregnancy, and often are adaptive in nature, i.e., do not require special medical intervention, the prompt diagnosis and treatment of hemostatic disorders as main pathogenetic link in the development of thrombosis is extremely important.

The article presented data of the complex examination of 79 women aged of 24-43 years with uterine form of infertility, including the determination of immunohistochemical markers (ER, PR, Ki-67, CD34, CD56, CD68, CD138, VEGF) in endometrium. As a result of the study there was revealed the decline in the number of CD56-positive cells, decrease or no expression of CD138, the increase in expression of CD34, decreased VEGF expression. The deterioration of implantation processes in patients with uterine form of infertility, presumably is related to the low content of immune competent cells and inhibition of angiogenesis, as well as a weak proliferative activity of the endometrium, as evidenced by a decrease expression of Ki-67.

It studied 300 outpatients patients urological and gynecological departments of “M.A. Tver'e Medical unit number 9” for 2013-2015 years. We investigated: the incidence of microbial associations in various age groups; the number of reported cases ofAIDS-related on the pathogen; frequency of genital infections among the unemployed; identification ofpatients with factor promiscuity. It was found that among the topical genital infections are currently defined chlamydia, ureaplasma and mycoplasma, viruses of herpes group, which may be associated with HIV.

Implantation is a highly co-ordinated event that requires delicate embryonic and endometrial interaction. Despite intensive devepolment of reproductive medicine and embryology implantation is still the less controlled stage of advanced reproductive technologies. The aim of the study was to evaluate the impact of colony-stimulating growth factor on implantation and clinical pregnancy rate in patients with repeated implantation failure.

Recurrent pregnancy loss - polietiologic complication of gestational process, which consists in spontaneous abortion or missed abortion 2 or more times in a row. Despite extensive investigation of this problem, there is still no clear understanding of the pathophysiological mechanisms which lead to miscarriage.

Results of treatment of 107 patients who had sacrocolpopexy for the treatment of apical prolapsed were evaluated. Regarding short- and long-term results low postoperative pain score, few complications, satisfactory and good anatomical and functional outcomes in the most cases were noted. Laparoscopic and robot-assisted approach can be considered as a minimally invasive method, the “gold standard” in the treatment of apical and posterior prolapse, however, there is a risk of recurrence of cystocele in the presence of multiple defects pubocervical fascia.

This article presents our results of laparoscopic hysterectomy among 100 morbid obese patients (BMI > 35 kg/m2). Incidence of somatic disorders, operative time and anesthesia, complications rate, accuracy of final histological diagnosis were analyzed. We believe that laparoscopic approach for hysterectomy is preferable in experienced hands and in well equipped OR due to low complication rate, less traumatism and fast recovery.

Polycystic ovary syndrome is one of the most studied pathologies in gynecology, but the etiology and pathogenesis has not been fully elucidated. An important role in the treatment of combined oral contraceptives play a latest-generation progestogen, such as drospirenone. The use of combined oral contraceptives with antiandrogen activity justified pathogenetically.

Based Therapeutic and Rehabilitation Center Russian Ministry of Public Health conducted a study whose purpose was to determine the efficacy of focused ultrasound ablation under MRI control in conserving therapy of adenomyosis.

We used the mesenchymal stem cells of the bone marrow of laboratory rats, which are then cultured in vitro and plated onto polypropylene synthetic biodegradable matrices are used for surgical treatment ofpelvic organ prolapse (PROLENE MESH PMM3). After 14 days, the monolayer formed of bone marrow mesenchymal stem cells, fill the cell reticulated matrix. Next is the implantation of the resulting cell engineering design under the fascia in the abdominal wall and tracked the result by histology after 1.5 and 4.5 months. Bone marrow mesenchymal stem cells can be used to improve the biocompatibility of implanted mesh for the surgical treatment of pelvic organ prolapse.

In this article we analyze a possible medical background and anthropometrical preconditions for a development ofsymphysiolis in groups of pregnant women with pelvic girdle pain syndrome (PPGP) and symptom-free pregnant controls. In PPGG-group there were also a statistically higher percentage of neuromuscular disorders including radiculopathy, cervicalgia, thoracalgia, back pain, low back pain, degenerative disc disease, myositis and migraines.

In recentyears, experts noted increased attention to the problem of benign breast diseases dishormonal-mastitis, the frequency of which in the population is up to 56%. Concern increased incidence of mastitis in adolescent girls as the unfavorable course of the disease is associated with high risk.