Vol 3, No 4 (2016)

Original study articles

Metabolic syndrome

Sosnova E.A.

Abstract

Metabolic syndrome characterized by tissue insulin resistance, hyperinsulinemia, impaired glucose tolerance, essential hypertension, dyslipidemia, and abdominal obesity and hyperuricemia in the same patient, not accidentally is causing the great interest of researchers. In clinical lecture there are presented data concerning both different variants of the metabolic syndrome (MS) and its prevalence rate in the population. There are given as well diagnostic criteria for MS as algorithm of examination ofpatients. There is considered the concept of the treatment of metabolic syndrome.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):172-180
pages 172-180 views

The course of pregnancy and blood coagulation system

Murashko A.V., Drapkina Y.S., Koroleva N.S.

Abstract

Pregnancy represents the procoagulant state, giving rise in the high prevalence rate of thrombotic complications. An imbalance between coagulation and anticoagulation systems of blood during pregnancy can lead to the development of pre-eclampsia, intrauterine growth retardation, preterm labor, premature rupture offetal membranes and fetal death. These complications are mostly caused by the impaired generation of thrombin as well as changes in the concentration and activity of tissue factor TFPI (tissue factor pathway inhibitor), TAT III complex and protein Z. Nevertheless, it should be noted that the thrombotic complications during pregnancy depend not on the elevation of the concentrations of specific coagulation factors or lack of the activity of anticoagulant proteins, but on the shift in the whole system toward the procoagulant state. These disorders most of all lead to thromboses ofplacental vessels, causing disorders ofperfusion of the affected area. Placental pathology can develop as from the maternal as from the fetal side. Despite the fact that changes in the blood coagulation system occur from the very beginning of pregnancy, and often are adaptive in nature, i.e., do not require special medical intervention, the prompt diagnosis and treatment of hemostatic disorders as main pathogenetic link in the development of thrombosis is extremely important.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):181-187
pages 181-187 views

Tactics of the management of patients with atypical endometrial hyperplasia

Baburin D.V., Unanyan A.L.

Abstract

This review deals with modern aspects of the management of patients with endometrial hyperplasia with atypia. There are considered modalities of different types of drug therapy and surgical treatment.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):188-192
pages 188-192 views

Profile features immunohistochemical endometrium in patients uterine form of infertility

Arutyunyan N.A., Dzhibladze T.A., Zuev V.M., Ishchenko A.I., Bryunin D.V., Khokhlova I.D.

Abstract

The article presented data of the complex examination of 79 women aged of 24-43 years with uterine form of infertility, including the determination of immunohistochemical markers (ER, PR, Ki-67, CD34, CD56, CD68, CD138, VEGF) in endometrium. As a result of the study there was revealed the decline in the number of CD56-positive cells, decrease or no expression of CD138, the increase in expression of CD34, decreased VEGF expression. The deterioration of implantation processes in patients with uterine form of infertility, presumably is related to the low content of immune competent cells and inhibition of angiogenesis, as well as a weak proliferative activity of the endometrium, as evidenced by a decrease expression of Ki-67.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):193-197
pages 193-197 views

Method of the sampling of biological material for the biological examination in the obstetric-gynecological practice

Kaptilnyy V.A.

Abstract

Overview describes the bacteriological method of the examination in the modern obstetric-gynecological practice. Particular attention is paid to the value of this method, the diagnostic relevance of results of the examination. There is described the preparation for the examination, aim, the technology of the performance. The accompanying photographs show in detail all the stages of the free vaginal discharge collection from the urogenital tract.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):198-203
pages 198-203 views

KhARAKTER I ChASTOTA VYDELENIYa MIKROBNYKh PATOGENOV, ASSOTsIIROVANNYKh S VICh-INFEKTsIEY, V RAZLIChNYKh OTDELAKh REPRODUKTIVNOY SISTEMY ZhENShchIN

Nekrasova L.V., Skachedub R.G., Makhmudova S.E., Tokareva D.A., Sabanova S.V., Nekrasova A.M.

Abstract

It studied 300 outpatients patients urological and gynecological departments of “M.A. Tver'e Medical unit number 9” for 2013-2015 years. We investigated: the incidence of microbial associations in various age groups; the number of reported cases ofAIDS-related on the pathogen; frequency of genital infections among the unemployed; identification ofpatients with factor promiscuity. It was found that among the topical genital infections are currently defined chlamydia, ureaplasma and mycoplasma, viruses of herpes group, which may be associated with HIV.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):204-205
pages 204-205 views

METODIKA «SAKROSPINAL'NAYa GISTEROPEKSIYa CYRENE®» DLYa KhIRURGIChESKOY KORREKTsII IZOLIROVANNOGO APIKAL'NOGO PROLAPSA. PERVYY OPYT V ROSSII

Nikitin A.N., Ishchenko A.I., Aleksandrov L.S.

Abstract

The trial, that was conducted to analyze the results of surgical treatment of isolated apical prolapse using the “Sacrospinal hysteroppexy CYRENE®” method, has shown high efficacy and low morbidity.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):205-206
pages 205-206 views

VLIYaNIE KOLONIESTIMULIRUYuShchEGO FAKTORA ROSTA NA IMPLANTATsIYu V PROGRAMME KONTROLIRUEMOY STIMULYaTsII SUPEROVULYaTsII U PATsIENTOK S POVTORNYM NEEFFEKTIVNYM PRIMENENIEM VSPOMOGATEL'NYKh REPRODUKTIVNYKh TEKhNOLOGIY

Obidnyak D.M., Gzgzyan A.M., Niauri D.A., Dzhemlikhanova L.K.

Abstract

Implantation is a highly co-ordinated event that requires delicate embryonic and endometrial interaction. Despite intensive devepolment of reproductive medicine and embryology implantation is still the less controlled stage of advanced reproductive technologies. The aim of the study was to evaluate the impact of colony-stimulating growth factor on implantation and clinical pregnancy rate in patients with repeated implantation failure.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):206-207
pages 206-207 views

BEREMENNOST' I RASSEYaNNYY SKLEROZ: VZAIMOVLIYaNIE, OPREDELENIE TAKTIKI RODORAZREShENIYa I PROGNOZOV DAL'NEYShEGO TEChENIYa ZABOLEVANIYa POSLE RODOV

Ovcharenko D.V.

Abstract

Multiple sclerosis (MS) - quite a widespread chronic multifactorial autoimmune neurodegenerative disease of central nervous system, which is based on the disintegration of the myelin sheath (dymyelination). The disease occurs in waves with exacerbations and remissions, often affects women, debuting at the age younger than 18 and older than 45 years. Until the 90s it was thought that pregnancy and the MS are not compatible because of the possible adverse effects ofpregnancy on the course of MS. Over the last 20 years, there was a global inversion of views on this issue.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):207-208
pages 207-208 views

PATOFIZIOLOGIChESKAYa ROL' SVOBODNORADIKAL'NYKh PROTsESSOV PRI PRIVYChNOY POTERE PLODA

Pokaleneva M.S.

Abstract

Recurrent pregnancy loss - polietiologic complication of gestational process, which consists in spontaneous abortion or missed abortion 2 or more times in a row. Despite extensive investigation of this problem, there is still no clear understanding of the pathophysiological mechanisms which lead to miscarriage.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):208-209
pages 208-209 views

ROL' BIOKhIMIChESKIKh MARKEROV V PROGNOZIROVANII PORAZhENIYa TsNS NOVOROZhDENNYKh PRI PREZhDEVREMENNYKh RODAKh

Popova N.G., Samusevich A.N., Ignatko I.V.

Abstract

The main goal of a prospective study of 84 pregnant women and children who were born at 22-36 weeks gestational age was estimation predictively adverse criteria of cerebral pathology in premature babies. For the evaluation offetal and newborn’s state we performed cerebral vessels ultrasound dopplerography, neurosonography and determine the level of CNS injury biomarkers in cord blood. The study findings suggest the interaction between perinatal outcomes and initial circulation failure of the fetal CNS blood flow in 97% of cases. The concentration of CNS injury biomarkers (S-100 protein, neuro-specific enolase, antibodies to nerve growth factor, myelin basic protein) should be considered as prognostic criteria to determine a degree ofpreterm babies’ CNS affliction.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):209-210
pages 209-210 views

LAPAROSKOPIChESKAYa I ROBOT-ASSISTIROVANNAYa SAKROKOL'POPEKSIYa. FUNKTsIONAL'NYE REZUL'TATY

Popov A.A., Atroshenko K.V., Fomenko O.Y., Fedorov A.A., Manannikova T.N., Tyurina S.S., Koval' A.A., Barto R.A.

Abstract

Results of treatment of 107 patients who had sacrocolpopexy for the treatment of apical prolapsed were evaluated. Regarding short- and long-term results low postoperative pain score, few complications, satisfactory and good anatomical and functional outcomes in the most cases were noted. Laparoscopic and robot-assisted approach can be considered as a minimally invasive method, the “gold standard” in the treatment of apical and posterior prolapse, however, there is a risk of recurrence of cystocele in the presence of multiple defects pubocervical fascia.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):210-211
pages 210-211 views

ABLATsIYa ENDOMETRIYa PRI GIPERPLASTIChESKIKh PROTsESSAKh U ZhENShchIN PERIMENOPAUZAL'NOGO VOZRASTA

Popov A.A., Manannikova T.N., Alieva A.S., Barto R.A.

Abstract

In this article presented results of microwave endometrial ablation using «Microsulis» technology in 18 patients with endometrial hyperplasia. Somatic pathology, anamnesis and clinical findings, postoperative results were analized. Microwave endometrial ablation is an alternative method of treatment of endometrial hyperplastic processes in view of the minimal invasiveness.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):211-212
pages 211-212 views

ISKhODY LAPAROSKOPIChESKOY GISTEREKTOMII U BOL'NYKh S MORBIDNYM OZhIRENIEM

Popov A.A., Manannikova T.N., Fedorov A.A., Loginova E.A., Golovin A.A., Lysenko S.N., Budykina T.S., Koval' A.A.

Abstract

This article presents our results of laparoscopic hysterectomy among 100 morbid obese patients (BMI > 35 kg/m2). Incidence of somatic disorders, operative time and anesthesia, complications rate, accuracy of final histological diagnosis were analyzed. We believe that laparoscopic approach for hysterectomy is preferable in experienced hands and in well equipped OR due to low complication rate, less traumatism and fast recovery.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):212-213
pages 212-213 views

OZhIRENIE KAK FAKTOR RISKA NARUShENIY MENSTRUAL'NOGO TsIKLA U ZhENShchIN REPRODUKTIVNOGO VOZRASTA

Raykova A.A.

Abstract

Obesity is one of the most common chronic diseases in the world. In recent years accumulated a large amount of data on the impact of obesity on the menstrual cycle. At the base of disorders of the pituitary - gonadal axis in women with changes in obesity are the central regulatory mechanisms function of ovary, adrenal cortex and changes in the metabolism of sex steroids in peripheral tissues. Weight loss helps to normalize cycle.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):213-214
pages 213-214 views

PRIMENENIE KOMBINIROVANNYKh ORAL'NYKh KONTRATsEPTIVOV, SODERZhAShchIKh DROSPIRENON, PRI LEChENII SINDROMA POLIKISTOZNYKh YaIChNIKOV

Raykova A.A.

Abstract

Polycystic ovary syndrome is one of the most studied pathologies in gynecology, but the etiology and pathogenesis has not been fully elucidated. An important role in the treatment of combined oral contraceptives play a latest-generation progestogen, such as drospirenone. The use of combined oral contraceptives with antiandrogen activity justified pathogenetically.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):214-215
pages 214-215 views

TEChENIE BEREMENNOSTI I RODOV U VICh-INFITsIROVANNYKh ZhENShchIN

Rybakova T.N.

Abstract

The results ofprevention of HIV vertical transmission were evaluated in HIV-infected pregnant women. The study involved 25 women, all carried out according to the protocol on the prevention of 12.03.2004 № 46/1-3 of Health Department of Ryazan. The results of our research have shown that the prevention of vertical transmission scheme is effective in 100% of all cases, and allows to get healthy children from HIV-infected mothers.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):215-216
pages 215-216 views

ORGANOSOKhRANYaYuShchEE LEChENIE ADENOMIOZA: MIF ILI REAL'NOST'?

Savel'eva Y.S., Sinitsyn V.E., Ishchenko A.I., Zhumanova E.N., Chunaeva E.A.

Abstract

Based Therapeutic and Rehabilitation Center Russian Ministry of Public Health conducted a study whose purpose was to determine the efficacy of focused ultrasound ablation under MRI control in conserving therapy of adenomyosis.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):216-217
pages 216-217 views

ANTENATAL'NOE PROGNOZIROVANIE PORAZhENIY TsNS PRI PREZhDEVREMENNYKh RODAKh

Safonova N.E., Popova N.G.

Abstract

To establish predictively adverse criteria of cerebral pathology in prematurely born children in comparison with the antenatal indicators offetal condition and outcomes of physiological pregnancies and at the menacing premature birth was the main objective a research. Prospective research ofantenatal ultrasonic cerebral arguments, dopplerometric arguments of circulation of blood in fetus and postnatal indicators in main (n = 40) and control groups (n = 30) is conducted. Statistical analysis of fetus and newborns examination the following adverse indicators of cerebral pathology at prematurely born children are observed: decrease in an index of resistance of internal carotid arteries, decrease in an index of resistance (RI) and the pulsation index (PI) in an middle cerebral artery, decrease in a circulation of blood in Galen’s vein, increase ofRI and PI in vertebral and the bazilar arteries, increase of SDR in uterine arteries and umbilical arteries. Considering existence of high neuroplasticity of a fetal brain and ability to compensate the disturbances arising in the perinatal period, the obtained data can be used as early diagnostics of the beginning injury of central nervous system at premature birth and their treatment at the earliest stages.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):217-218
pages 217-218 views

ISPOL'ZOVANIE KLETOChNYKh TEKhNOLOGIY V KhIRUGIChESKOM LEChENII TAZOVOGO PROLAPSA

Sulina Y.Y., Ishchenko A.I., Lyundup A.V., Aleksandrov L.S., Ishchenko A.A., Muravlev A.I.

Abstract

We used the mesenchymal stem cells of the bone marrow of laboratory rats, which are then cultured in vitro and plated onto polypropylene synthetic biodegradable matrices are used for surgical treatment ofpelvic organ prolapse (PROLENE MESH PMM3). After 14 days, the monolayer formed of bone marrow mesenchymal stem cells, fill the cell reticulated matrix. Next is the implantation of the resulting cell engineering design under the fascia in the abdominal wall and tracked the result by histology after 1.5 and 4.5 months. Bone marrow mesenchymal stem cells can be used to improve the biocompatibility of implanted mesh for the surgical treatment of pelvic organ prolapse.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):219-220
pages 219-220 views

PRIMENENIE MIFEPRISTONA I MIZOPROSTOLA DLYa PRERYVANIYa BEREMENNOSTI NA RANNIKh SROKAKh

Tokareva D.A., Bolotskaya N.V., Makhmudova S.E.

Abstract

It studied 43 outpatients pregnant women, medical abortion held in MSH Design Bureau JSC “Russian Railways”, Perm', to study the effect of drugs for medical abortion. The mostfrequent periods of interruption ofpregnancy were identified. The study found the most common complication of this method - incomplete abortion requiring surgical intervention.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):220-220
pages 220-220 views

ANAMNESTIChESKIE I ANTROPOMETRIChESKIE PREDPOSYLKI V RAZVITII SIMFIZIOPATII PRI BEREMENNOSTI

Cherkasova N.Y.

Abstract

In this article we analyze a possible medical background and anthropometrical preconditions for a development ofsymphysiolis in groups of pregnant women with pelvic girdle pain syndrome (PPGP) and symptom-free pregnant controls. In PPGG-group there were also a statistically higher percentage of neuromuscular disorders including radiculopathy, cervicalgia, thoracalgia, back pain, low back pain, degenerative disc disease, myositis and migraines.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):221-221
pages 221-221 views

OTsENKA SOSTOYaNIYa REPRODUKTIVNOGO ZDOROV'Ya SOVREMENNOY POPULYaTsII DEVOChEK-PODROSTKOV

Khodzhaeva A.S.

Abstract

Comparative analysis of medico-biological and social health indicators showed negative trends have a significant part of the modern population of adolescent girls in the CIS countries (Uvarova E.V., 2013; Vasil'eva T.P. et al., 2013.), including in Uzbekistan (Irgasheva S.U., 2014; Ayupova F.M., 2012). Upon reaching this generation of childbearing age there is a real risk of various reproductive disorders. In this connection it is necessary to urgently improve evaluation methods and the primary prevention of violations of the reproductive health of adolescent girls - the foundation of the reproductive health of mothers and children.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):222-223
pages 222-223 views

OSOBENNOSTI VOZNIKNOVENIYa MASTOPATII U DEVOChEK-PODROSTKOV

Khodzhaeva A.S.

Abstract

In recentyears, experts noted increased attention to the problem of benign breast diseases dishormonal-mastitis, the frequency of which in the population is up to 56%. Concern increased incidence of mastitis in adolescent girls as the unfavorable course of the disease is associated with high risk.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):223-223
pages 223-223 views

MORFOFUNKTsIONAL'NOE SOSTOYaNIE RUBTsA PRI RAZLIChNYKh METODIKAKh UShIVANIYa MATKI V EKSPERIMENTE

Khudoley E.P.

Abstract

On 24 rabbits carred out 2 series experiments. In control seriae (n = 15) cut on uterus restored of seam by Reverden of thread Vycril 6/0, in experiment seriae (n = 9) - seam by Reverden of thread Vycril 6/0 strengthened by means ofnet implant of thread Prolen. Animals exterminated from experiments on 7, 30 and 60 days. Condacted of macroscopic and histologic researchs after autopsy. In experiment seriae net implantant of thread Prolen called of unimportant unorganization of muscle tissue, architectonic of muscle tissue change unimportant.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(4):224-224
pages 224-224 views


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