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Vol 5, No 2 (2018)

Original papers

PECULIARITIES OF THE STATE OF THE HEPATOBILIARY SYSTEM IN THE PHYSIOLOGICAL COURSE OF PREGNANCY AND AGAINST THE BACKGROUND OF DRUG ADMINISTRATION

Novruzova D.R., Sosnova E.A.

Abstract

The review provides information on the clinical and physiological features of the functioning of the hepatobiliary system in women during a normally developing pregnancy. The causes and magnitude of changes in specific blood biochemical indices in pregnant women are analyzed. An analysis of various liver pathologies in pregnant women associated with the administration of frequently prescribed medications is also presented.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):60-64
pages 60-64 views

MODERN IDEAS ABOUT THE MANAGEMENT OF LABOR IN HIGH-DEGREE MYOPIA

Aslamazova A.E., Fokina N.D., Berishvili M.V., Bykova E.L., Berishvili T.Z., Krasilshchikov I.M.

Abstract

The increase in the incidence of myopia and peripheral chorioretinal dystrophies in patients of childbearing age leads to the appearance of new methods of vision correction, as well as to the formation of new standards of medical care in the management of pregnancy and delivery.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):65-68
pages 65-68 views

ANTIPHOSPHOLIPID SYNDROME AS THE MOST IMPORTANT LINK IN THE GENESIS OF FAILURE OF IN VITRO FERTILIZATION

Klyukina L.A.

Abstract

In the article, there are analyzed main pathogenetic aspects of the relationship between antiphospholipid syndrome (APS) and reproductive losses, obstetric pathology, as well as possible methods for improving pathogenetic prophylaxis of repeated failures of in vitro fertilization (IVF). Based on the literature data, there is made a conclusion about the need for further studies of the role of antiphospholipid antibodies (AFA) as a cause of IVF failures, as well as the search for the most effective methods of preventing repeated failures of this procedure in a group of women with APS.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):69-76
pages 69-76 views

POLYMORPHISM OF SOME GENES IN PATIENTS WITH CHRONIC ENDOMETRITIS

Kobaidze E.G., Padrul M.M.

Abstract

Chronic inflammation of the endometrium is one of the causes of infertility and impaired menstrual function. The issues of the diagnosis and treatment of this disease are often discussed, but remains too unclear. In connection with this, the study of the role of genetic polymorphism in patients with chronic endometritis is topical. The occurrence of polymorphisms in promoter sites of VEGF, ApoE, ESR1, PPARGC1A, MMP9, eNOS genes in patients with chronic endometritis and in practically healthy women were studied. As primers, the DNA portion of the VEGF genes rs2010963 (G634C), ApoE rs429358 (Cys130Arg), ESR1 2228480 (Thr594Thr), PPARGC1A 8192678 (Gly482Ser), MMP9 17576 (Gln279Arg), and eNOS 1799983 (Glu298Asp) were used. To study the polymorphic variants of genes investigated, a real-time polymerase chain reaction was used, the material was sampled by smear extraction from the mucous membrane of the oropharynx. In the analysis, the percentage of homozygotes and heterozygotes, the prevalence of the normal and pathological (minor) allele were counted. Based on the results obtained, it can be assumed that in patients with chronic endometritis polymorphism of genes responsible for angiogenesis, oxidative processes in the body and metabolism is more common. In particular, there was noted a statistically significant predominance of polymorphism in the promoter sites of the eNOS and ESR1 genes in patients with chronic endometritis, which may be indicative of negative genetic associations with impaired fertility; at the same time, the issues of the presence of genetic polymorphism of the genes MMP9, VEGF and ApoE and a lower frequency of somatic and gynecological pathology in a group of practically healthy women require further study.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):77-82
pages 77-82 views

POSSIBILITIES OF THE IMPLEMENTATION OF SURGICAL INTERVENTIONS AIMED AT CORRECTING THE PROLAPSE OF PELVIC ORGANS, IN THE CONDITIONS OF THE GYNECOLOGICAL DEPARTMENT OF THE MUNICIPAL MATERNITY HOSPITAL

Ishchenko A.A., Ishchenko A.I., Aleksandrov L.S., Gilyadova A.V.

Abstract

Introduction. Prolapse of pelvic organs is a polyethological disease, manifested by the displacement of the uterus and the walls of the vagina to the vulvar ring or out of it. At the base of this pathology, there is the functional inconsistency of the ligament apparatus of internal genital organs and pelvic floor musclesoccurring due to the impact of various physical, genetic, psychological, age, hormonal, iatrogenic etiological factors. Prolapse of the pelvic organs is an actual problem due to the high incidence of both reproductive and elderly women. This article considers the effectiveness of criteria for selection patients with different degrees of prolapse of the genitals for the implementation of surgical correction in conditions of the gynecological department of the municipal maternity hospital. Material and methods. The sample included patients with initial, post-hysterectomic, recurrent anterior and apical prolapse of the genitalia of II-IV degree according to POP-Q classification in the age cohort of 45-70 years who do not have systemic diseases, or with a compensated systemic disease that does not introduce significant limitations in physical and social activity. Depending on the severity of pelvic prolapse, patients underwent various types of surgical treatment. In 5 patients with incomplete uterine prolapse, there was performed laparoscopic extraperitoneal ligature hysterosuspension and vaginal wall plasty using reticular implants, and in the 1 patient with the complete prolapse of the uterus, there was made the vaginal extirpation of the uterus with extraperitoneal colposuspension vaginal walls plasty using a reticular implant. Women with adjacent gynecological pathology (24 patients) underwent laparoscopic (22) and laparotomic (2) operations for the main disease and the plasty of the vaginal walls (including 19 patients using reticular implants). In one case, a patient with elongation of the cervix and the lowering of the anterior wall of the vagina there was performed a modification of the Manchester operation using a reticular implant. In 3 patients with the isolated prolapse of the anterior wall of the vagina, the vaginal wall plasty was made with the installation of a reticular implant. Results. After the surgical interventions, no intraoperative, as well as early or late postoperative complications were noted. The evaluation of the effectiveness of the performed surgical treatment according to follow up in the period of from 12 months to 5 years, revealed 1 case of the recurrence of the disease in the form of cervical stump prolapse in a 58-year-old patient managed with succeed promonofixation of the cervical stump with a reticular implant. Conclusion. The high anatomical (94.4%) and functional (96.8%) efficacy of the surgical treatment of the prolapse of pelvic organs allow judging the persuasiveness of selection criteria for surgical correction of the genital prolapse in conditions of the gynecological department of the maternity hospital.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):83-87
pages 83-87 views

INVESTIGATION OF MICRORNA LEVELS IN BLOOD PLASMA IN PREGNANT WOMEN WITH GESTATIONAL ARTERIAL HYPERTENSION, PREECLAMPSIA, AND FETAL GROWTH RETARDATION SYNDROME

Murashko A.V., Simonova M.S., Goryunova A.G., Chebanov D.K., Abramov A.A., Chaplygin E.Y.

Abstract

MicroRNAs are small non-coding RNAs (20-24 nucleotides) that regulate gene expression through post-transcriptional repression or degradation of the template RNA. The role of microRNA during pregnancy is currently poorly understood. Some studies have identified a microRNA profile associated with pregnancy since it was present in the placenta and maternal blood throughout pregnancy. In this study, we compared individual expression levels of 10 microRNAs in the maternal peripheral blood samples and further estimated their association with adverse pregnancy outcomes including preeclampsia, gestational arterial hypertension, and fetal growth retardation syndrome. MicroRNAs can be used as a non-invasive biomarker to identify an adverse obstetric outcome and with the potent therapeutic target for the prevention or treatment of pathology of pregnancy. Further research with a large sample size in different populations is needed to confirm our results.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):88-92
pages 88-92 views

BIPOLAR VAGINAL HYSTERECTOMY IN THE FUTURE AND PRESENT

Slobodyanyuk A.I., Ishchenko A.A., Ishchenko A.I., Slobodyanyuk B.A.

Abstract

Vaginal hysterectomy seems to be the optimal access, but this method does not take a worthy place in operative gynecology. In this study, a prospective comparison of 2 different techniques of vaginal hysterectomy was performed in 125 patients with the use of vicryl ligatures and 215 patients using bipolar coagulation devices (Gyrus and Emed) in different clinics. In the analysis of immediate and remote results, in the group with electrosurgery, blood loss, operation time and pain syndrome at 4 and 48 hours were found to be statistically significantly less. Also, we did not discern any differences in the number of postoperative complications, which allows us to make conclusions regarding the safety and effectiveness of the use of modern bipolar coagulation devices by experienced surgeons.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):93-96
pages 93-96 views

MARKERS OF ANTIOXIDANT PROTECTION SYSTEM IN DIAGNOSTICS OF EXTERNAL GENITAL ENDOMETRIOSIS IN INFERTILITY FEMALE PATIENTS

Khatlamadzhiyan M.G., Kharitonova E.V., Anisimova U.S., Shcherbakova L.N., Bugerenko A.E., Kalenikova E.I., Panina O.B.

Abstract

To identify markers of the antioxidant defense, 43 female patients with the infertility associated with external genital endometriosis were examined. The control group consisted of 19 healthy fertile women. In endometriosis patients, a statistically significant (p < 0.01) plasma level of coenzyme Q10 and α-tocopherol, determined by means of high-performance liquid chromatography with electrochemical detection, were noted to be lower in the comparison with the control group. On the basis of the data obtained, there was developed a prognostic scale that allows verifying the presence and severity of external genital endometriosis in infertility female patients.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):97-100
pages 97-100 views

LACTOFERRIN, FLUORESCENT TECHNOLOGIES AND THEIR ROLE IN THE DIAGNOSIS AND TREATMENT OF INFLAMMATORY DISEASES OF THE FEMALE SEXUAL SPHERE

Zuev V.M., Gulenkova D.G., Goldman I.L., Sadchikova E.R., Aleksandrov M.T.

Abstract

The article reflects a modern view on the introduction of fluorescent methods of diagnostics and treatment of vaginal infections using lactoferrin in clinical microbiology, which made it possible to expand microecological studies. The suppression of the normal vaginal microflora was shown to promote a diverse pathology of both inflammatory and non-inflammatory genesis. Bacterial and fungal vaginosis were proved to be the most important risk factors for the development of infectious complications in the gynecological practice. There are given substantiated scientific evidence, indicating a large number of recurrences of bacterial and candidal vaginitis, despite the numerous studies and various treatment options. The relationship of bacterial vaginitis with infertility, the threat of miscarriage, premature birth, intrauterine infection of the fetus, etc. was established. Based on this, the search for alternative combined methods is relevant. The aim of the study was to increase the effectiveness of the treatment of recurrent candid vulvovaginitis and bacterial vaginosis by using lactoferrin. In the study, there were used fluorescent methods of the diagnosis, which made it possible to verify the diagnosis in the rapid assessment mode, as well as monitor treatment and improve its effectiveness.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):101-105
pages 101-105 views

METHODS OF PERFORMING A PLAIN AND ADVANCED COLPOSCOPY

Kaptilny V.A., Belova A.V.

Abstract

This review is devoted to the technique of the performing colposcopy in the modern obstetrical and gynecological practice. Special attention is paid to the value of this method, the diagnostic significance of the results of the survey. The preparation for the study, the purpose, and methodology of its implementation are considered. The presented photographs illustrate in detail all the stages of the course of colposcopy.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2018;5(2):106-112
pages 106-112 views

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