Vol 4, No 2 (2017)

Laparoscopic ovarian drilling is now considered to be a safe and effective surgical method. The frequency of the onset of pregnancy is similar tothat of the therapeutic methods of ovulation induction. At the same time, a lower risk of ovarian hyperstimulation syndrome and multiple pregnancies makes drilling more preferable to gonadotropin therapy. Despite the advantages of this method of surgical treatment, the issue of possible complications still remains to be relevant.

Hypothyreosis is one of the most common endocrine pathologies closely related with the reproductive system. In female patients with hypofunction of the thyroid gland, various disorders occur in the reproductive system: menstrual cycle deteriorations, miscarriage, infertility. Therefore, the study of thyroid function should be carried out as a screening in women planning pregnancy, as well as in infertile couples in the treatment of the infertility. When hypothyreosis is detected, L-thyroxine replacement therapy is necessary.

Fertility in women with congenital dysfunction of the adrenal cortex (CDAC) due to the insufficiency of 21-hydroxylase (n21-OH) is presumed to decrease, especially in women with classic salt-losing type. Several factors contribute to the development of subfertility: an excess of androgens, adrenal hypersecretion of progesterone, the consequences of the reconstructive genital surgery, a syndrome of secondary polycystic ovaries and psychosexual factors. Adequate glucocorticoid therapy and the improvement of surgical and psychological care can contribute to the optimization of infertility in CDAC patients, even in classical variant women. This review contains up-to-date information on reproductive outcomes in CDAC women due to n21-OH, infertility and pregnancy problems.