延长女性生育期：现代方法与抗衰老治疗

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随着人类寿命的延长以及推迟初次妊娠的趋势，促使人们寻找能够延长女性生育期并提高生活质量的有效方法。本文为综述性文章，旨在分析构成卵巢老化基础的生理和分子过程，并探讨旨在改善卵巢储备和维持生育力的现有抗衰老策略。重点论述了氧化应激、线粒体功能障碍、包括DNA修饰在内的表观遗传机制作用，以及多种创新性治疗方法。例如，富血小板血浆（platelet-rich plasma, PRP）卵巢内注射、干细胞在卵巢组织再生中的应用、针对衰老细胞的清除性疗法，以及通过线粒体捐赠改善卵母细胞质量的前沿技术。文中还引用了临床与实验研究的数据，证明上述策略在保持女性生育潜能方面的有效性，为不孕症治疗、生活质量改善及女性延迟生育提供了新的可能。文章同时探讨了现有方法的局限性及这一领域未来的动态发展方向。

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作者简介

Svetlana V. Kamoeva

Clinic "K+31" West; Pirogov Russian National Research Medical University

编辑信件的主要联系方式.
Email: sv02016@yandex.ru
ORCID iD: 0000-0002-7238-9911
SPIN 代码: 6059-0738

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Moscow; 1 Ostrovityanov st, Moscow, 117997

Diana S. Makovskaya

Clinic "K+31" West

Email: littlede@rambler.ru
ORCID iD: 0000-0003-0159-8641
SPIN 代码: 9161-6635
俄罗斯联邦, Moscow

Yulia E. Dobrokhotova

Pirogov Russian National Research Medical University

Email: pr.dobrohotova@mail.ru
ORCID iD: 0000-0002-7830-2290
SPIN 代码: 2925-9948

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, 1 Ostrovityanov st, Moscow, 117997

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ЭЛ № ФС 77 - 80633 от 15.03.2021 г.