<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Архив акушерства и гинекологии им. В.Ф. Снегирева</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-8726</issn><issn publication-format="electronic">2687-1386</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">656699</article-id><article-id pub-id-type="doi">10.17816/aog656699</article-id><article-id pub-id-type="edn">HEWZJI</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Extending the reproductive period in women: modern approaches and anti-aging therapy</article-title><trans-title-group xml:lang="ru"><trans-title>Продление репродуктивного периода у женщин: современные подходы и анти-эйдж-терапия</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>延长女性生育期：现代方法与抗衰老治疗</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7238-9911</contrib-id><contrib-id contrib-id-type="spin">6059-0738</contrib-id><name-alternatives><name xml:lang="en"><surname>Kamoeva</surname><given-names>Svetlana V.</given-names></name><name xml:lang="ru"><surname>Камоева</surname><given-names>Светлана Викторовна</given-names></name><name xml:lang="zh"><surname>Kamoeva</surname><given-names>Svetlana V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>sv02016@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0159-8641</contrib-id><contrib-id contrib-id-type="spin">9161-6635</contrib-id><name-alternatives><name xml:lang="en"><surname>Makovskaya</surname><given-names>Diana S.</given-names></name><name xml:lang="ru"><surname>Маковская</surname><given-names>Диана Сергеевна</given-names></name><name xml:lang="zh"><surname>Makovskaya</surname><given-names>Diana S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>littlede@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7830-2290</contrib-id><contrib-id contrib-id-type="spin">2925-9948</contrib-id><name-alternatives><name xml:lang="en"><surname>Dobrokhotova</surname><given-names>Yulia E.</given-names></name><name xml:lang="ru"><surname>Доброхотова</surname><given-names>Юлия Эдуардовна</given-names></name><name xml:lang="zh"><surname>Dobrokhotova</surname><given-names>Yulia E.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>pr.dobrohotova@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Clinic "K+31" West</institution></aff><aff><institution xml:lang="ru">Клиника «К+31» Запад</institution></aff><aff><institution xml:lang="zh">Clinic "K+31" West</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет им. Н.И. Пирогова</institution></aff><aff><institution xml:lang="zh">Pirogov Russian National Research Medical University</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-08-24" publication-format="electronic"><day>24</day><month>08</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-10-26" publication-format="electronic"><day>26</day><month>10</month><year>2025</year></pub-date><volume>12</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>268</fpage><lpage>277</lpage><history><date date-type="received" iso-8601-date="2025-02-19"><day>19</day><month>02</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-08-10"><day>10</day><month>08</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025,</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2027-10-26"/></permissions><self-uri xlink:href="https://archivog.com/2313-8726/article/view/656699">https://archivog.com/2313-8726/article/view/656699</self-uri><abstract xml:lang="en"><p>The increase in life expectancy and the trend toward postponing first pregnancy have stimulated the search for effective methods to extend the reproductive period in women and to improve their quality of life. This review analyzes current understanding of the physiological and molecular processes underlying ovarian aging, as well as contemporary anti-aging strategies aimed at enhancing ovarian reserve and maintaining fertility. Particular attention is given to the role of oxidative stress, mitochondrial dysfunction, and epigenetic mechanisms, including DNA modifications, along with innovative therapeutic approaches. Specifically, platelet-rich plasma (PRP) therapy (intraovarian injection of platelet-rich plasma), the use of stem cells for ovarian tissue regeneration, senotherapy targeting the elimination of senescent cells, and the prospects of mitochondrial donation technology to improve oocyte quality are discussed. Clinical and experimental studies demonstrating the efficacy of these strategies in preserving reproductive potential are presented, highlighting new opportunities in infertility treatment, quality-of-life improvement, and enabling later motherhood. Limitations and future research directions in this rapidly evolving field are also discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Увеличение продолжительности жизни и тенденция к отсрочке планирования первой беременности стимулируют поиск эффективных методов продления репродуктивного периода у женщин и повышение качества их жизни. Настоящая обзорная статья посвящена анализу современных представлений о физиологических и молекулярных процессах, лежащих в основе старения яичников, и актуальных анти-эйдж-стратегий, направленных на улучшение овариального резерва и поддержание фертильности. Особое внимание уделено роли окислительного стресса, митохондриальной дисфункции, эпигенетическим механизмам, включая модификации ДНК, а также инновационным терапевтическим подходам. В частности, рассмотрены PRP-терапия (внутрияичниковая инъекция обогащённой тромбоцитами плазмы), применение стволовых клеток для регенерации ткани яичников, сенотерапия, направленная на элиминацию стареющих клеток, и перспективы технологии митохондриального донорства для улучшения качества ооцитов. Представлены данные клинических и экспериментальных исследований, демонстрирующие эффективность этих стратегий для сохранения репродуктивного потенциала, что открывает новые горизонты в лечении бесплодия, улучшении качества жизни и предоставлении женщинам возможностей для более позднего материнства. Обсуждаются ограничения и перспективы дальнейших исследований в этой динамично развивающейся области.</p></trans-abstract><trans-abstract xml:lang="zh"><p>随着人类寿命的延长以及推迟初次妊娠的趋势，促使人们寻找能够延长女性生育期并提高生活质量的有效方法。本文为综述性文章，旨在分析构成卵巢老化基础的生理和分子过程，并探讨旨在改善卵巢储备和维持生育力的现有抗衰老策略。重点论述了氧化应激、线粒体功能障碍、包括DNA修饰在内的表观遗传机制作用，以及多种创新性治疗方法。例如，富血小板血浆（platelet-rich plasma, PRP）卵巢内注射、干细胞在卵巢组织再生中的应用、针对衰老细胞的清除性疗法，以及通过线粒体捐赠改善卵母细胞质量的前沿技术。文中还引用了临床与实验研究的数据，证明上述策略在保持女性生育潜能方面的有效性，为不孕症治疗、生活质量改善及女性延迟生育提供了新的可能。文章同时探讨了现有方法的局限性及这一领域未来的动态发展方向。</p></trans-abstract><kwd-group xml:lang="en"><kwd>anti-aging</kwd><kwd>ovarian reserve</kwd><kwd>fertility</kwd><kwd>PRP therapy</kwd><kwd>mitochondrial dysfunction</kwd><kwd>oxidative stress</kwd><kwd>senotherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>анти-эйдж</kwd><kwd>овариальный резерв</kwd><kwd>фертильность</kwd><kwd>PRP-терапия</kwd><kwd>митохондриальная дисфункция</kwd><kwd>оксидативный стресс</kwd><kwd>сенотерапия</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>抗衰老</kwd><kwd>卵巢储备</kwd><kwd>生育力</kwd><kwd>PRP疗法</kwd><kwd>线粒体功能障碍</kwd><kwd>氧化应激</kwd><kwd>衰老疗法</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Uryupina KV, Kutsenko II, Kravtsova EI, Gavryuchenko PA. Ovarian infertility factor in patients of late reproductive age. Medical Herald of the South of Russia. 2020;11(1):14–20. doi: 10.21886/2219-8075-2020-11-1-14-20 EDN: XHUYNL</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Findlay JK, Hutt KJ, Hickey M, et al. How is the number of primordial follicles in the ovarian reserve established? Biol Reprod. 2015;93(5):111. doi: 10.1095/biolreprod.115.133652</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Berezina DA, Kudryavtseva EV, Gavrilov IV. Role of oxidative stress in female reproductive system: literature review. Perm Medical Journal. 2023;40(4):62–72. doi: 10.17816/pmj40462-72 EDN: CUJHQS</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Chon SJ, Umair Z, Yoon MS. Premature ovarian insuffciency: past, present, and future. Front Cell Dev Biol. 2021;9:672890. doi: 10.3389/fcell.2021.672890</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Podfgurna-Stopa A, Czyzyk A, Grymowicz M, et al. Premature ovarian insufciency: the context of longterm efects. J Endocrinol Invest. 2016;39(9):983–990. doi: 10.1007/s40618-016-0467-z</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Malek AM, Vladutiu CJ, Meyer ML, et al. The association of age at menopause and all-cause and cause-specifc mortality by race, postmenopausal hormone use, and smoking status. Prev Med Rep. 2019;15:100955. doi: 10.1016/j.pmedr.2019.100955</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Cavalcante MB, Sampaio OGM, Câmara FEA, et al. Ovarian aging in humans: potential strategies for extending reproductive lifespan. Geroscience. 2023;45(4):2121–2133. doi: 10.1007/s11357-023-00768-8</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Agarwal A, Durairajanayagam D, du Plessis SS. Oxidative stress and female reproduction: an update. Reprod Biomed Online. 2021;42(5):813–816. doi: 10.1186/1477-7827-10-49</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Avila J, Gonzalez-Fernandez R, Rotoli D, et al. Oxidative stress in granulosa-lutein cells from in vitro fertilization patients. Reprod Sci. 2016;23(12):1656–1661. doi: 10.1177/1933719116674077</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Moolhuijsen LME, Visser JA. Anti-Müllerian hormone and ovarian reserve: update on assessing ovarian function. J Clin Endocrinol Metab. 2020;105(11):3361–3373. doi: 10.1210/clinem/dgaa513</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Knight AK, Hipp HS, Abhari S, et al. Markers of ovarian reserve are associated with reproductive age acceleration in granulosa cells from IVF patients. Hum Reprod. 2022;37(10):2438–2445. doi: 10.1093/humrep/deac178</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>de Kat AC, Broekmans FJM, Lambalk CB. Role of AMH in prediction of menopause. Front Endocrinol (Lausanne). 2021;12:733731. doi: 10.3389/fendo.2021.733731</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Zhang JJ, Liu X, Chen L, et al. Advanced maternal age alters expression of maternal effect genes that are essential for human oocyte quality. Aging (Albany NY). 2020;12(4):3950–3961. doi: 10.18632/aging.102864</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Chun Y, Kim J. Autophagy: an essential degradation program for cellular homeostasis and life. Cells. 2018;7(12):278. doi: 10.3390/cells7120278</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Savitsky DV, Linkova NS, Kozhevnikova EO, et al. SASP of endothelium and vascular smooth muscle cells: role in pathogenesis and therapy of atherosclerosis. Molecular Medicine. 2022;(4):9–15. doi: 10.29296/24999490-2022-04-02 EDN: CECRWC</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Guo Z, Yu Q. Role of mTOR signaling in female reproduction. Front Endocrinol (Lausanne). 2019;10:692. doi: 10.3389/fendo.2019.00692</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Wang J, Sun X, Yang Z, et al. Epigenetic regulation in premature ovarian failure: a literature review. Front Physiol. 2023;13:998424. doi: 10.3389/fphys.2022.998424</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Rea IM, Gibson DS, McGilligan V, et al. Age and age-related diseases: role of inflammation triggers and cytokines. Front Immunol. 2018;9:586. doi: 10.3389/fimmu.2018.00586</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Shirasuna K, Iwata H. Effect of aging on the female reproductive function. Contracept Reprod Med. 2017;2:23. doi: 10.1186/s40834-017-0050-9</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Secomandi L, Borghesan M, Velarde M, Demaria M. The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions. Hum Reprod Update. 2022;28(2):172–189. doi: 10.1093/humupd/dmab038</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Newson L. Menopause and cardiovascular disease. Post Reprod Health. 2018;24(1):44–49. doi: 10.1177/2053369117749675</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Manson JE, Chlebowski RT, Stefanick ML, et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials. JAMA. 2013;310(13):1353–68. doi: 10.1001/jama.2013.278040</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Xu L, Hu C, Liu Q, Li Y. The effect of dehydroepiandrosterone (DHEA) supplementation on IVF or ICSI: a meta-analysis of randomized controlled trials. Geburtshilfe Frauenheilkd. 2019;79(7):705–712. doi: 10.1055/a-0882-3791</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Wang Y, Hekimi S. Understanding ubiquinone. Trends Cell Biol. 2016;26(5):367–378. doi: 10.1016/j.tcb.2015.12.007</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Xu Y, Nisenblat V, Lu C, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018;16(1):29. doi: 10.1186/s12958-018-0343-0</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Zhang Y, Zhang C, Shu J, et al. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod Update. 2020;26(2):247–263. doi: 10.1093/humupd/dmz046</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Tamura H, Takasaki A, Taketani T, et al. Melatonin and female reproduction. J Obstet Gynaecol Res. 2014;40(1):1–11. doi: 10.1111/jog.12177</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>He C, Wang J, Zhang Z, et al. Mitochondria synthesize melatonin to ameliorate its function and improve mice oocyte's quality under in vitro conditions. Int J Mol Sci. 2016;17(6):939. doi: 10.3390/ijms17060939</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Potiris A, Stavros S, Voros C, et al. Intraovarian platelet-rich plasma administration for anovulatory infertility: preliminary findings of a prospective cohort study. Journal of Clinical Medicine. 2024;13(17):5292. doi: 10.3390/jcm13175292</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Sills ES, Rickers NS, Li X, Palermo GD. First data on in vitro fertilization and blastocyst formation after intraovarian injection of calcium gluconate-activated autologous platelet rich plasma. Gynecol Endocrinol. 2018;34(9):756–760. doi: 10.1080/09513590.2018.1445219</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Kasaven LS, Saso S, Getreu N, et al. Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation? Hum Reprod. 2022;37(9):1970–1979. doi: 10.1093/humrep/deac144</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Practice committee of the American society for reproductive medicine. Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion. Fertil Steril. 2019;112(6):1022–1033. doi: 10.1016/j.fertnstert.2019.09.013</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Pacheco F, Oktay K. Current success and efciency of autologous ovarian transplantation: a meta-analysis. Reprod Sci. 2017;24(8):1111–1120. doi: 10.1177/1933719117702251</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Farnezi HCM, Goulart ACX, Santos AD, et al. Three-parent babies: Mitochondrial replacement therapies. JBRA Assist Reprod. 2020;24(2):189–196. doi: 10.5935/1518-0557.20190086</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Zhao YX, Chen SR, Su PP, et al. Using mesenchymal stem cells to treat female infertility: an update on female reproductive diseases. Stem Cells Int. 2019;2019:9071720. doi: 10.1155/2019/9071720</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Castrillon DH, Miao L, Kollipara R, et al. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science. 2003;301(5630):215–218. doi: 10.1126/science.1086336</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Skaznik-Wikiel ME, Swindle DC, Allshouse AA, et al. High-fat diet causes subfertility and compromised ovarian function independent of obesity in mice. Biol Reprod. 2016;94(5):108. doi: 10.1095/biolreprod.115.137414</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Clarke SL, Reaven GM, Leonard D, et al. Cardiorespiratory fitness, body mass index, and markers of insulin resistance in apparently healthy women and men. Am J Med. 2020;133(7):825–830.e2. doi: 10.1016/j.amjmed.2019.11.031</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Bala R, Singh V, Rajender S, Singh K. Environment, lifestyle, and female infertility. Reprod Sci. 2021;28(3):617–638. doi: 10.1007/s43032-020-00279-3</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Biryukova DA, Amyan TS, Gavisova AA, et al. The effect of stress on the female reproductive system: pathophysiology and neuroendocrine interactions. Akusherstvo i Ginekologiya. 2023;(11):36–42. doi: 10.18565/aig.2023.175 EDN: JKJWDK</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Pignolo RJ, Passos JF, Khosla S, et al. Reducing senescent cell burden in aging and disease. Trends Mol Med. 2020;26(7):630–638. doi: 10.1016/j.molmed.2020.03.005</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Paez-Ribes M, Gonzalez-Gualda E, Doherty GJ, Munoz-Espin D. Targeting senescent cells in translational medicine. EMBO Mol Med. 2019;11(12):e10234. doi: 10.15252/emmm.201810234</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Dou X, Sun Y, Li J, et al. Short-term rapamycin treatment increases ovarian lifespan in young and middle-aged female mice. Aging Cell. 2017;16(4):825–836. doi: 10.1111/acel.12617</mixed-citation></ref></ref-list></back></article>
