History of preeclampsia: The significance of first-trimester biochemical screening of pregnancy-associated plasma protein A and human chorionic gonadotropin in predicting recurrence
- Authors: Galeeva S.A.1, Fatkullina I.B.1, Gareev E.M.1, Tadzhiboeva N.A.1, Stetsenko N.A.1, Lazareva A.Y.1, Sitdikova D.G.1
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Affiliations:
- Bashkir State Medical University
- Issue: Vol 9, No 3 (2022)
- Pages: 181-188
- Section: Original study articles
- URL: https://archivog.com/2313-8726/article/view/107702
- DOI: https://doi.org/10.17816/2313-8726-2022-9-3-181-188
- ID: 107702
Cite item
Abstract
AIM: We aimed at assessing the significance of first-trimester biochemical screening of pregnancy-associated plasma protein A (РАРР-А) and human chorionic gonadotropin (hCG) in predicting the recurrence of preeclampsia (PE) in pregnant women with early and late history of gestational PE.
MATERIALS AND METHODS: A retrospectively included 94 labor histories and prenatal medicals records of pregnant women (2020–2021). Moreover, their first-trimester biochemical screening parameters (РАРР-А and hCG) with a gestational PE history were performed to predict the recurrence of PE. They were divided into three groups (two study groups and a control group). Groups 1 and 2 included 31 labor histories each with late- and early-onset PE, respectively. Group 3 (controls) consisted of 32 labor histories with uncomplicated pregnancies.
RESULTS: In the groups with a gestational PE history and recurrence, a significant decrease in РАРР-А levels was found at 11–14 weeks of gestation. We equally observed high levels of first-trimester hCG in late-onset PE, most probably due moderate degrees of PE recurrence and not gestational age. However, severe degrees of recurrence prevailed in early-onset PE.
CONCLUSIONS: A decrease in РАРР-А levels measured at 11–14 weeks of gestation is a significant predictor of recurrence of PE in the group of pregnant women with a gestational PE history.
Full Text
About the authors
Svetlana A. Galeeva
Bashkir State Medical University
Email: svetagaleeva04@gmail.com
ORCID iD: 0000-0002-6911-3367
postgraduate student
Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008Irina B. Fatkullina
Bashkir State Medical University
Email: fib1971@mail.ru
ORCID iD: 0000-0001-5723-2062
MD, Dr. Sci. (Med.), Professor
Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008Evgenii M. Gareev
Bashkir State Medical University
Email: gem46@list.ru
ORCID iD: 0000-0002-6561-0892
MD, Cand. Sci. (Med.), Assistant Professor
Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008Nadzhiba A. Tadzhiboeva
Bashkir State Medical University
Email: najibatojiboeva@gmail.com
ORCID iD: 0000-0002-1863-3784
postgraduate student
Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008Natal’ya A. Stetsenko
Bashkir State Medical University
Email: natali.polyudova@yandex.ru
ORCID iD: 0000-0003-4247-2295
postgraduate student
Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008Anna Yu. Lazareva
Bashkir State Medical University
Email: lazarevaayu@mail.ru
ORCID iD: 0000-0002-8299-0268
postgraduate student
Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008Dinara G. Sitdikova
Bashkir State Medical University
Author for correspondence.
Email: Edi4ka1@mail.ru
ORCID iD: 0000-0001-8425-6553
postgraduate student
Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008References
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