History of preeclampsia: The significance of first-trimester biochemical screening of pregnancy-associated plasma protein A and human chorionic gonadotropin in predicting recurrence

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Abstract

AIM: We aimed at assessing the significance of first-trimester biochemical screening of pregnancy-associated plasma protein A (РАРР-А) and human chorionic gonadotropin (hCG) in predicting the recurrence of preeclampsia (PE) in pregnant women with early and late history of gestational PE.

MATERIALS AND METHODS: A retrospectively included 94 labor histories and prenatal medicals records of pregnant women (2020–2021). Moreover, their first-trimester biochemical screening parameters (РАРР-А and hCG) with a gestational PE history were performed to predict the recurrence of PE. They were divided into three groups (two study groups and a control group). Groups 1 and 2 included 31 labor histories each with late- and early-onset PE, respectively. Group 3 (controls) consisted of 32 labor histories with uncomplicated pregnancies.

RESULTS: In the groups with a gestational PE history and recurrence, a significant decrease in РАРР-А levels was found at 11–14 weeks of gestation. We equally observed high levels of first-trimester hCG in late-onset PE, most probably due moderate degrees of PE recurrence and not gestational age. However, severe degrees of recurrence prevailed in early-onset PE.

CONCLUSIONS: A decrease in РАРР-А levels measured at 11–14 weeks of gestation is a significant predictor of recurrence of PE in the group of pregnant women with a gestational PE history.

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About the authors

Svetlana A. Galeeva

Bashkir State Medical University

Email: svetagaleeva04@gmail.com
ORCID iD: 0000-0002-6911-3367

postgraduate student

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Irina B. Fatkullina

Bashkir State Medical University

Email: fib1971@mail.ru
ORCID iD: 0000-0001-5723-2062

MD, Dr. Sci. (Med.), Professor

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Evgenii M. Gareev

Bashkir State Medical University

Email: gem46@list.ru
ORCID iD: 0000-0002-6561-0892

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Nadzhiba A. Tadzhiboeva

Bashkir State Medical University

Email: najibatojiboeva@gmail.com
ORCID iD: 0000-0002-1863-3784

postgraduate student

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Natal’ya A. Stetsenko

Bashkir State Medical University

Email: natali.polyudova@yandex.ru
ORCID iD: 0000-0003-4247-2295

postgraduate student

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Anna Yu. Lazareva

Bashkir State Medical University

Email: lazarevaayu@mail.ru
ORCID iD: 0000-0002-8299-0268

postgraduate student

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Dinara G. Sitdikova

Bashkir State Medical University

Author for correspondence.
Email: Edi4ka1@mail.ru
ORCID iD: 0000-0001-8425-6553

postgraduate student

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

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Supplementary files

Supplementary Files
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1. Fig. 1. Levels of RARP-A in the control group (without a history of preeclampsia) and in groups with late and early manifestations of preeclampsia in the anamnesis.

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2. Fig. 2. Human chorionic gonadotropin (hCG) levels in the control group (without a history of preeclampsia) and in groups with late and early manifestations of preeclampsia in the anamnesis.

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3. Fig. 3. MoM–RARP-A levels in the absence of relapse of preeclampsia and moderate and severe relapse severity.

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4. Fig. 4. RARP-A levels in the absence of relapse of preeclampsia and moderate and severe relapse severity.

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5. Fig. 5. Human chorionic gonadotropin (hCG) levels in the absence of relapse of preeclampsia and moderate to severe relapse severity.

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