The role of integrins in the formation of the placental increment (placenta accreta spectrum)

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Abstract

One of the most serious pregnancy complications is currently considered as a violation of cytotrophoblast invasion, particularly, a pathologically increased depth of invasion, leading to the formation of the placental increment (placenta accreta), ingrowth (placenta increta), and germination (placenta percreta). Cytotrophoblast invasion is regulated through subtle intercellular interactions, an important role among which is played by integrins, transmembrane glycoproteins that contribute to the immersion of cytotrophoblast in the endometrium and myometrium. The balance disturbance in the expression of α1β1, α5β1, and α6β4 integrins after normal implantation form a pathological extravillous trophoblast (EVT) phenotype by the blastocyst. This review examines the importance of integrins, collagens, and fibronectin in the formation of placental ingrowth (placenta accreta spectrum).

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About the authors

Viktoriya A. Efimova

I.M. Sechenov First Moscow State Medical University

Email: efimova299@mail.ru

IV-year student

Russian Federation, 119991, Moscow

Ekaterina E. Rudenko

I.M. Sechenov First Moscow State Medical University

Email: redikor2@yandex.ru
ORCID iD: 0000-0002-0000-1439

MD, Cand. Sci. (Med.)

Russian Federation, 119991, Moscow

Andrey V. Murashko

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: murashkoa@mail.ru
ORCID iD: 0000-0003-0663-2909
SPIN-code: 2841-9638

M.D., Dr. Sci. (Med.), professor

Russian Federation, 119991, Moscow

Ol’ga A. Lobanova

I.M. Sechenov First Moscow State Medical University

Email: lobanova.98@mail.ru
ORCID iD: 0000-0002-6813-3374

V-year student

Russian Federation, 119991, Moscow

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