The role of integrins in the formation of the placental increment (placenta accreta spectrum)

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One of the most serious pregnancy complications is currently considered as a violation of cytotrophoblast invasion, particularly, a pathologically increased depth of invasion, leading to the formation of the placental increment (placenta accreta), ingrowth (placenta increta), and germination (placenta percreta). Cytotrophoblast invasion is regulated through subtle intercellular interactions, an important role among which is played by integrins, transmembrane glycoproteins that contribute to the immersion of cytotrophoblast in the endometrium and myometrium. The balance disturbance in the expression of α1β1, α5β1, and α6β4 integrins after normal implantation form a pathological extravillous trophoblast (EVT) phenotype by the blastocyst. This review examines the importance of integrins, collagens, and fibronectin in the formation of placental ingrowth (placenta accreta spectrum).

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作者简介

Viktoriya Efimova

I.M. Sechenov First Moscow State Medical University

Email: efimova299@mail.ru

IV-year student

俄罗斯联邦, 119991, Moscow

Ekaterina Rudenko

I.M. Sechenov First Moscow State Medical University

Email: redikor2@yandex.ru
ORCID iD: 0000-0002-0000-1439

MD, Cand. Sci. (Med.)

俄罗斯联邦, 119991, Moscow

Andrey Murashko

I.M. Sechenov First Moscow State Medical University

编辑信件的主要联系方式.
Email: murashkoa@mail.ru
ORCID iD: 0000-0003-0663-2909
SPIN 代码: 2841-9638

M.D., Dr. Sci. (Med.), professor

俄罗斯联邦, 119991, Moscow

Ol’ga Lobanova

I.M. Sechenov First Moscow State Medical University

Email: lobanova.98@mail.ru
ORCID iD: 0000-0002-6813-3374

V-year student

俄罗斯联邦, 119991, Moscow

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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