The role of integrins in the formation of the placental increment (placenta accreta spectrum)

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

One of the most serious pregnancy complications is currently considered as a violation of cytotrophoblast invasion, particularly, a pathologically increased depth of invasion, leading to the formation of the placental increment (placenta accreta), ingrowth (placenta increta), and germination (placenta percreta). Cytotrophoblast invasion is regulated through subtle intercellular interactions, an important role among which is played by integrins, transmembrane glycoproteins that contribute to the immersion of cytotrophoblast in the endometrium and myometrium. The balance disturbance in the expression of α1β1, α5β1, and α6β4 integrins after normal implantation form a pathological extravillous trophoblast (EVT) phenotype by the blastocyst. This review examines the importance of integrins, collagens, and fibronectin in the formation of placental ingrowth (placenta accreta spectrum).

Full Text

Restricted Access

About the authors

Viktoriya A. Efimova

I.M. Sechenov First Moscow State Medical University

Email: efimova299@mail.ru

IV-year student

Russian Federation, 119991, Moscow

Ekaterina E. Rudenko

I.M. Sechenov First Moscow State Medical University

Email: redikor2@yandex.ru
ORCID iD: 0000-0002-0000-1439

MD, Cand. Sci. (Med.)

Russian Federation, 119991, Moscow

Andrey V. Murashko

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: murashkoa@mail.ru
ORCID iD: 0000-0003-0663-2909
SPIN-code: 2841-9638

M.D., Dr. Sci. (Med.), professor

Russian Federation, 119991, Moscow

Ol’ga A. Lobanova

I.M. Sechenov First Moscow State Medical University

Email: lobanova.98@mail.ru
ORCID iD: 0000-0002-6813-3374

V-year student

Russian Federation, 119991, Moscow

References

  1. Lash GE, Ernerudh J. Decidual cytokines and pregnancy complications: focus on spontaneous miscarriage. J Reprod Immunol. 2015;108:83–89. doi: 10.1016/j.jri.2015.02.003
  2. Damsky CH, Librach C, Lim KH, et al. Integrin switching regulates normal trophoblast invasion. Development. 1994;120(12):3657–3666.
  3. Silver RM, Barbour KD. Placenta Accreta Spectrum. Accreta, Increta, and Percreta. Obstet Gynecol Clin North Amer. 2015;42(2):381–402.
  4. Mehrabadi A, Hutcheon JA, Liu S, et al. Contribution of placenta accreta to the incidence of postpartum hemorrhage and severe postpartum hemorrhage. Obstet Gynecol. 2015;125(4):814–821. doi: 10.1097/AOG.0000000000000722
  5. Irving C, Hertig AT. A study of placenta accrete. Surg Gynecol Obstet. 1937;64:178–200.
  6. Fox H. Placenta accreta: 1945–1969. Obstet Gynecol Surv. 1972;27(7):475–490.
  7. Benirschke K, Burton GJ, Baergen RN. Pathology of the human placenta. 6th ed. Berlin: Springer-Verlag; 2012.
  8. Jauniaux E, Jurkovic D. Placenta accreta: pathogenesis of a 20th century iatrogenic uterine disease. Placenta. 2012;33(4):244–251. doi: 10.1016/j.placenta.2011.11.010
  9. Jauniaux E, Collins S, Burton GJ. Placenta accreta spectrum: pathophysiology and evidence-based anatomy for prenatal ultrasound imaging. Am J Obstet Gynecol. 2018;218(1):75–87. doi: 10.1016/j.ajog.2017.05.067
  10. D’Antonio F, Iacovella C, Bhide A. Prenatal identification of invasive placentation using ultrasound: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2013;42:509–517. doi: 10.1002/uog.13194
  11. Flo K, Widnes C, Vårtun Å, Acharya G. Blood flow to the scarred gravid uterus at 22–24 weeks of gestation. BJOG. 2014;121:210–215. doi: 10.1111/1471-0528.12441
  12. Jauniaux E, Bhide A. Prenatal ultrasound diagnosis and outcome of placenta previa accreta after cesarean delivery: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017;217(1):27–36. doi: 10.1016/j.ajog.2017.02.050
  13. Strizhakov AN, Ignatko IV, Davydov AI. Obstetrics: textbook. Moscow: GEOTAR-Media; 2020. (In Russ). doi: 10.33029/9704-5396-4-2020-AKU-1-1072
  14. Knöfler M. Critical growth factors and signaling pathways controlling human trophoblast invasion. Int J Dev Biol. 2010;54(2–3):269–280. doi: 10.1387/ijdb.082769mk
  15. Plaisier M. Decidualization and angiogenesis. Best Pract Res Clin Obstet Gynaecol. 2011;25:259–271. doi: 10.1016/j.bpobgyn.2010.10.011
  16. Ailamazyan EK, Stepanova OI, Selkov SA, Sokolov DI. Cells of Immune System of Mother and Trophoblast Cells: Constructive operation for the Sake of Achievement of the Joint Purpose. Annals of the Russian academy of medical sciences. 2013;11:12–21. (In Russ).
  17. Tarrade A, Lai Kuen R, Malassiné A, et al. Characterization of human villous and extravillous trophoblasts isolated from first trimester placenta. Lab Invest. 2001;81(9):1199–1211. doi: 10.1038/labinvest.3780334
  18. Weitzner O, Seraya-Bareket C, Biron-Shental T, et al. Enhanced expression of αVβ3 integrin in villus and extravillous trophoblasts of placenta accrete. Arch Gynecol Obstet. 2021;303(5):1175–1183. doi: 10.1007/s00404-020-05844-4
  19. Gupton SL, Riquelme D, Hughes-Alford SK, et al. Mena binds α5 integrin directly and modulates α5β1 function. J Cell Biol. 2012;198(4):657–676. doi: 10.1083/jcb.201202079
  20. Carusi DA. The placenta accreta spectrum: Epidemiology and risk factors. Clin Obstet Gynecol. 2018;61(4):733–742. doi: 10.1097/GRF.0000000000000391
  21. Bachmann M, Kukkurainen S, Hytönen VP, Wehrle-Haller B. Cell adhesion by integrins. Physiol Rev. 2019;99(4):1655–1699. doi: 10.1152/physrev.00036.2018
  22. Knöfler M, Haider S, Saleh L, et al. Human placenta and trophoblast development: key molecular mechanisms and model systems. Cell Mol Life Sci. 2019;76(18):3479–3496. doi: 10.1007/s00018-019-03104-6
  23. Factor EG, Bonagura TW, Babischkin JS, et al. Prematurely elevating estradiol in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins. Endocrinology. 2012;153(6):2897–2906. doi: 10.1210/en.2012-1141
  24. Tikkanen M, Paavonen J, Loukovaara M, Stefanovic V. Antenatal diagnosis of placenta accreta leads to reduced blood loss. Acta Obstet Gynecol Scand. 2011;90(10):1140–1146. doi: 10.1111/j.1600-0412.2011.01147.x
  25. Hecht JL, Baergen R, Ernst LM, et al. Classification and reporting guidelines for the pathology diagnosis of placenta accreta spectrum (PAS) disorders: recommendations from an expert panel. Mod Pathol. 2020;33(12):2382–2396. doi: 10.1038/s41379-020-0569-1

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2022 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС 77 - 86335 от 11.12.2023 г.  
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ЭЛ № ФС 77 - 80633 от 15.03.2021 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies