Analysis of the cellular immunity status in patients with pathological placentation

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Abstract

AIM: The study aimed to investigate the cellular immunity in patients with placental disposition.

MATERIALS AND METHODS: A prospective study analyzed birth histories and clinical and laboratory parameters of 10 patients with placental disposition. The cellular immunity status was determined by analyzing lymphocytes with a cluster of differentiation (CD), including CD3+, CD4+, CD8+, CD16+56, CD3-СD8+, TNK, and CD38+8+. Obtained data were analyzed statistically.

RESULTS: Patients were 32.0 (29.0; 36.0) years old. As regards reproductive history, 60.0% had a history of three pregnancies, 20% had two pregnancies, 10% had their first pregnancy, and 10% had their fourth pregnancy. Moreover, placenta dispositions most often occurred at the second pregnancy in 70.0%, at the third pregnancy in 20.0%, and first pregnancy in 10%. In terms of cell immunity in comparison with normal indicators, the relative number of natural killer cells (CD16+56+), including activated CD3-СD8+, tended to increase. A relative increase in cytotoxic T-lymphocytes (СD8+) was found against the background of lower number of T-helper cells, along with general immunodeficiency (immunoregulatory index in the absolute number of women was less than 1.5).

CONCLUSIONS: Further investigation of cellular immunity in women with placental pathology is relevant to detect additional pathogenetic mechanisms of the development of obstetric complications.

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About the authors

Edvard A. Berg

Bashkir State Medical University

Email: aig.eaberg@gmail.com
ORCID iD: 0000-0002-2028-7796

assistant at Department of Obstetrics and Gynecology

Russian Federation, 3 Lenin Str., Ufa, 450008

Alfiya G. Yashchuk

Bashkir State Medical University

Email: alfiya_galimovna@mail.ru
ORCID iD: 0000-0003-2645-1662

MD, Dr. Sci. (Med.), Professor, Head Obstetrics and Gynecology Department

Russian Federation, 3 Lenin Str., Ufa, 450008

Il’nur I. Musin

Bashkir State Medical University

Author for correspondence.
Email: ilnur-musin@yandex.ru
ORCID iD: 0000-0001-5520-5845

MD, Cand. Sci. (Med.), Associate Professor of Department of Obstetrics and Gynecology

Russian Federation, 3 Lenin Str., Ufa, 450008

Raisa A. Naftulovich

Bashkir State Medical University

Email: aig.eaberg@gmail.com
ORCID iD: 0000-0003-2893-4844

MD, Cand. Sci. (Med.), Associate Professor of Department of Obstetrics and Gynecology

Russian Federation, 3 Lenin Str., Ufa, 450008

Elena M. Popova

Bashkir State Medical University

Email: aig.eaberg@gmail.com

assistant at Department of Obstetrics and Gynecology

Russian Federation, 3 Lenin Str., Ufa, 450008

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