Differential diagnosis of obstetric thrombotic microangiopathy: a review

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Abstract

Thrombotic microangiopathy (TMA) is a clinical and morphological syndrome, which is based on damage of the endothelium. Clinically, TMA is characterized by a triad of symptoms: thrombocytopenia, microangiopathic hemolytic anemia, and target organ damage. In obstetric practice, TMA most often occurs with preeclampsia or HELLP syndrome, atypical HUS, TTP. The review presents the basic differential criteria for the diagnosis of TMA during pregnancy and after childbirth, as well as the management of patients.

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About the authors

Polina I. Kukina

I.M. Sechenov First Moscow State Medical University

Email: renoru47@gmail.com

resident

Russian Federation, Moscow

Anastasiya V. Moskatlinova

I.M. Sechenov First Moscow State Medical University

Email: moskatav@mail.ru

resident

Russian Federation, Moscow

Irina M. Bogomazova

I.M. Sechenov First Moscow State Medical University

Email: irinka.bogomazova@mail.ru
ORCID iD: 0000-0003-1156-7726

Assistant Professor

Russian Federation, Moscow

Elena V. Timokhina

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: elena.timokhina@mail.ru
ORCID iD: 0000-0001-6628-0023

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

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