Efficacy of immunological antivirus therapy for papillomavirus-associated grade I cervical intraepithelial neoplasia

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AIM: The study aimed to assess the effectiveness of alloferon in human papillomavirus (HPV)-associated cervical neoplasia (grade I) based on the analysis of the cytokine profile in cervical mucus as well as markers of apoptosis in cervical epithelial cells.

MATERIALS AND METHODS: The study enrolled 98 women, including 55 women of reproductive age with cervical intraepithelial neoplasia (CIN) associated with HPV infection and 43 conditionally healthy women without HPV infection. Factors of cytokine response and markers of apoptosis under normal and pathology conditions were assessed and compared.

RESULTS: The imbalance of pro-inflammatory and anti-inflammatory cytokines, in favor of the latter, is an important factor that supports the persistence of HPV-associated grade I CIN. Reducing caspase-3 and caspase-9, increasing interleukin-18, and subsequent activation of interferon gamma against the background of alloferon use are favorable signs of substantial elimination of the HPV.

CONCLUSIONS: The results of this study show considerable elimination of HPV in patients with grade I CIN when using immunological antivirus therapy.

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About the authors

Ol’ga P. Vinogradova

Penza Institute of Advanced Training of Doctors — Branch of the Russian Medical Academy of Postgraduate Education

Author for correspondence.
Email: o_vinogradova69@mail.ru
ORCID iD: 0000-0002-9094-8772

M.D., Dr. Sci. (Med.), professor

Russian Federation, 8A Stasov str., Penza, 440060

Natal’ya A. Andreeva

Ogarev Mordovia State University

Email: andreeva_77@list.ru
ORCID iD: 0000-0002-2207-7039

MD, Cand. Sci. (Med.), assistant professor

Russian Federation, Saransk

Ol’ga V. Epifanova

Penza Institute of Advanced Training of Doctors — Branch of the Russian Medical Academy of Postgraduate Education

Email: epifanova.vrt@gmail.com
ORCID iD: 0000-0002-3961-809X

MD, assistant

Russian Federation, 8A Stasov str., Penza, 440060

Ol’ga I. Artemova

Scientific Research Institute of Fundamental and Applied Research of the Penza State University

Email: artyomovaolg@gmail.com
ORCID iD: 0000-0002-4996-026X

MD, junior researcher

Russian Federation, Penza


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Supplementary files

Supplementary Files
1. Fig. 1. Evaluation of the effectiveness of therapy in the study subgroups.

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2. Fig. 2. The concentration of IL-18 in the cervical mucus of the studied groups of women with CIN I, pg/ml.

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3. Fig. 3. The concentration of IFN-γ in women with CIN I associated with papillomavirus infection, pg/ml.

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4. Fig. 4. The concentration of TNF-α in the cervical mucus of the studied groups of women with CIN I, pg/ml.

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