LEPTIN LEVEL IN WOMEN OF REPRODUCTIVE AGE WITH THE SYNDROME OF THE POLYCYSTIC OVARY IN COMPARISON WITH HEALTHY WOMEN

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract


Material and methods. The study included 200 women of reproductive age, of whom the 1st group included 100 PCOS female patients and the 2nd group included 100 healthy women examined using clinical, instrumental, laboratory, and statistical methods. Results. Metabolic syndrome was diagnosed in 38 (38.0%) PCOS women of early reproductive age, while in healthy women only in 25 (25.0%) (p = 0.102). The serum leptin content in PCOS women amounted of 13.85 ng/ml (4.15-17.6), which was not significantly different from that of healthy women - of 8.9 ng/ml (5.5-18.4) (p = 0.732). However, in women with manifestations of metabolic syndrome (overweight and obesity), the level of leptin was higher than in women without metabolic syndrome - 16.7 ng/ml (15.6-18.8) and 19.3 ng/ml (17.4-22.8) in PCOS women - 31.7 ng/ml (21.6-38.6) and 27.3 ng/ml (20.1-32.1) in healthy women (p = 0.045 and 0.604, respectively). An increase in its level correlated with an increase in BMI (p = 0.001). We found that an increase in leptin levels in PCOS women of reproductive age correlated with its main manifestations: menstrual disorders, infertility and ultrasound parameters of the ovaries, with an increase in BMI, the relationship was stronger. Conclusion. Thus, in PCOS women of reproductive age, metabolic syndrome is more often diagnosed than in healthy women. Overweight and obesity are of major importance in the formation of metabolic disorders. Increased leptin levels exacerbate metabolic manifestations, leading to impaired ovulation and fertility. The results show the need to determine the level of leptin as an additional diagnostic criterion for metabolic syndrome in PCOS cases.

Full Text

Restricted Access

About the authors

Anzhelika Yu. Beglova

Kemerovo State Medical University

Email: angelik-1986@mail.ru
Kemerovo, 650056, Russian Federation
MD, Ph.D., Assistant of the Department of Obstetrics and Gynecology No. 1 of the Kemerovo State Medical University, Kemerovo, 650056, Russian Federation

S. I Elgina

Kemerovo State Medical University

Kemerovo, 650056, Russian Federation

References

  1. Назаренко Т.А., Мишиева Н.Г. Бесплодие и возраст: пути решения проблемы. 2-е изд. М.: МЕДпресс-информ; 2014.
  2. Дубровина С.О. Синдром поликистозных яичников: современный обзор. Гинекология. 2016; 18 (5): 14-9.
  3. Манухин И.Б., Тумилович Л.Г., Геворкян М.А., Манухина Е.И. Гинекологическая эндокринология. Клинические лекции. М.: ГЭОТАР-Медиа; 2017.
  4. Азизова М.Э. Синдром поликистозных яичников с позиций современных представлений. Казанский медицинский журнал. 2015; (1): 77-80.
  5. Ройтберг Г.Е., ред. Метаболический синдром. М.: МЕДпресс-информ; 2007.
  6. Хомбург Р. Стимуляция яичников. Практическое руководство. Перевод с англ. под ред. Когана И.Ю. М.: ГЭОТАР-Медиа; 2017.
  7. Lizneva D., Suturina L., Walker W., Brakta S., Gavrilova-Jordan L., Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Endocr. Rev. 2016;106(1): 6-15.
  8. Cottrell E.C., Mercer J.C. Leptin receptors. Handb. Exp. Pharmacol. 2012; 209: 3-21.
  9. Pasqulali R., Gambineri A. Metabolic effects of obersity on reproduction. Reprod. Biomed. Online. 2006; (5): 542-51.
  10. Коваренко М.А., Руяткина Л.А., Петрищева М.С., Бодавели О.В. Лептин: физиологические и патологические аспекты действия. Вестник НГУ. Серия Биология, клиническая медицина. 2003; 1 (1): 59-74.
  11. Рязанцева Е.М. Лептин в патогенезе овариальной недостаточности у женщин с ожирением. Журнал акушерства и женских болезней. 2016; (3): 18-23.
  12. Bani Mohammad M., Majdi Seghinsara A. Polycystic ovary syndrome (PCOS), diagnostic criteria and AMH. Asian Pac. J. Cancer Prev. 2017; 18(1): 17-21.
  13. Передереева Е.В., Лушникова А.А., Фрыкин А.Д., Пароконная А.А. Гормон лептин и проблема репродукции. Злокачественные опухоли. 2012; 2(1): 35-9. doi.org/10.18027/2224-5057-2012-1-35-39
  14. Синдром поликистозных яичников в репродуктивном возрасте (современные подходы к диагностике и лечению): клинические рекомендации (протокол лечения). М.; 2015. https://studfiles.net/preview/5778776/
  15. Фон Вольфф М., Штуте П. Гинекологическая эндокринология и репродуктивная медицина. Пер. с нем. под ред. Е.Н. Андреевой. 2-е изд. М.; 2018: 445-55.
  16. Yildiz B.O. Polycystic ovary syndrome: is obesity a symptom? Women’s Health. 2013; 9: 505-7.
  17. Pal L., ed. Polycystic ovary syndrome: current and emerging concepts. New York: Springer; 2014: 340.
  18. Краснопольская К.В., Назаренко Е.А. Клинические аспекты лечения бесплодия в браке. М.: ГЭОТАР-Медиа; 2014: 186-248.
  19. Legro R.S., Arslanian S.A., Ehrmann D.A., Hoeger K.M., Murad M.H., Pasquali R., Welt C.K. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2013; 98 (12): 4565-92.

Statistics

Views

Abstract - 99

PDF (Russian) - 0

Cited-By


Article Metrics

Metrics Loading ...

Refbacks

  • There are currently no refbacks.

Copyright (c) 2019 Eco-Vector



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies