Study of starfish low molecular weight metabolites: structures, biological activities and biosynthesis

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Abstract

Polar steroid compounds, sphingolipids, and triterpene glycosides of some species of tropical and Far Eastern starfish were studied. Their chemical structures, biological activity, and hypothetical pathways of biosynthesis have been established. Many of the isolated compounds have a unique chemical structure and contain unusual structural fragments.

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About the authors

Timofey V. Malyarenko

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Author for correspondence.
Email: malyarenko-tv@mail.ru
ORCID iD: 0000-0002-6594-8471

Candidate of Sciences in Chemistry, Senior Researcher

Russian Federation, Vladivostok

Alla A. Kicha

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: kicha@piboc.dvo.ru
ORCID iD: 0000-0002-1371-0103

Doctor of Sciences in Chemistry, Leading Researcher

Russian Federation, Vladivostok

Victor M. Zakharenko

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: rarf247@gmail.com
ORCID iD: 0000-0001-5809-6250

Junior Researcher

Russian Federation, Vladivostok

Natalia V. Ivanchina

Elyakov Pacific Institute of Bioorganic Chemistry of FEB RAS

Email: ivanchina@piboc.dvo.ru
ORCID iD: 0000-0001-9075-8584

Candidate of Sciences in Chemistry, Head of the Laboratory

Russian Federation, Vladivostok

References

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Supplementary files

Supplementary Files
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2. Fig. 1. Structures of microdiscusols A-G (1-7) and microdiscusoside A (8) from sea star A. microdiscus

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3. Fig. 2. Structures of granulatosides D (9) and E (10) and holothurin A2 (= echinoside A) (11) from the sea star C. granulatus

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4. Fig. 3. Structures of polyhydroxysteroids 12-15 from sea star A. laevigatus and acanthaglycoside G (16) from sea star A. planci

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5. Fig. 4. Structures of compounds 17-26 from the starfish C. patagonicus

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6. Fig. 5. Structures of pacificusosides A-C (27-29) from the sea star S. pacificus

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7. Fig. 6. Hypothetical scheme of the biosynthesis of the side chain of pacificusoside A (27)

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8. Fig. 7. Structures of pacificusosides D-K (30-32, 34-38) and cucumarioside D (33) from the sea star S. pacificus

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9. Fig. 8. Structures of compounds 39-43 from the starfish P. marsippus

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