Evaluation of effectiveness of the diets developed for children with allergical pathology living in conditions of adverse environmental exposures

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Abstract

Introduction. Nutrition is one of the important preventive measures aimed at enhancing body resistance to adverse effects of environmental factors. Nutrition modelling taking into account its basic quality and environmental exposures is of particular importance for effective management of risks for the disease.

Our objective was to assess the effectiveness of the diets specially developed for children with allergies environmentally exposed to industrial pollutants.

Materials and methods. We examined cytomorphological features, nutritional status, general health status, and skin manifestations in eighty 3 to 6-year children suffering from allergies and sensitized to food products.

Results. A hypoallergenic elimination and detoxification diet specially developed with account for food intolerance, immune status, protein, energy and micronutrient sufficiency, genomic status, mental and physical health of the preschoolers with allergies led to a 1.5-fold decrease in the number of underweight children and a threefold average drop in blood levels of lead, aluminum, arsenic, copper, and cadmium. The mean number of children with clinical manifestations of food intolerance demonstrated the 1.6-fold decline, the level of sIgA increased, while cytogenetic abnormalities in buccal epithelium decreased by 2.1 times.

Limitations. A limitation of the study was the lack of compliance of parents with recommendations for nutritional support.

Conclusions. The applied method of modelling the diet using dietary techniques based on basic nutrition data, toxic exposures, genetics, anthropometric, clinical, and immunological indicators has had a beneficial effect on all assessed health parameters in children with allergies living in a large industrial city.

Compliance with ethical standards. Study approval was provided by the Local Ethics Committee of Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers (protocol No. 5 of December 27, 2021). Written informed consent was obtained from parents of all examined children.

Contribution:
Mazhaeva T.V. — study conception and design, draft manuscript preparation;
Dubenko S.E. — data collection, analysis and interpretation of results, draft manuscript preparation.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship. We are grateful for the assistance provided in the research to Shtin T.N., Bushueva T.V., Minigalieva I.A., Klinova S.V., Shaikhova D.R., Bereza I.A., Chebotarkova S.A., Scientific Director Gurvich V.B., and Director Sutunkova M.P. for participating in research.

Received: October 23, 2023 / Accepted: November 15, 2023 / Published: December 28, 2023

About the authors

Tatyana V. Mazhaeva

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Author for correspondence.
Email: mazhaeva@ymrc.ru
ORCID iD: 0000-0002-8566-2446

MD, PhD, Leading Researcher, Head of the Department of Nutrition Hygiene, Food Quality and Safety, Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, 620014, Russian Federation

e-mail: mazhaeva@ymrc.ru

Russian Federation

Svetlana E. Dubenko

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: noemail@neicon.ru
ORCID iD: 0000-0001-8008-6024
Russian Federation

References

  1. London S.J., Romieu I. Gene by environment interaction in asthma. Annu. Rev. Public Health. 2009; 30: 55–80. https://doi.org/10.1146/annurev.publhealth.031308.100151
  2. Erwin J.A., Marchetto M.C., Gage F.H. Mobile DNA elements in the generation of diversity and complexity in the brain. Nat. Rev. Neurosci. 2014; 15(8): 497–506. https://doi.org/10.1038/nrn3730
  3. Olbrich C.L., Bivas-Benita M., Xenakis J.J., Maldonado S., Cornwell E., Fink J., et al. Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation. Mucosal Immunol. 2020; 13(5): 777–87. https://doi.org/10.1038/s41385-020-0310-x
  4. Mazhaeva T.V., Dubenko S.E., Shtin T.N., Yarushin S.V., Chebotar’kova S.A. Signs of phenotypic changes in children constantly exposed to elevated environmental levels of chemical pollutants in the city of Nizhny Tagil. Zdorov’e naseleniya i sreda obitaniya – ZNiSO. 2022; 30(9): 77–83. https://doi.org/10.35627/2219-5238/2022-30-9-77-83 https://elibrary.ru/bhlyoq (in Russian)
  5. Bushueva T.V., Minigalieva I.A., Klinova S.V., Shaikhova D.R., Bereza I.A., Amromina A.M., et al. Immunochemical, cytogenetic changes and genetic polymorphism in children living under the exposure to unfavourable environmental factors. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2022; 101(12): 1555–56. https://doi.org/10.47470/0016-9900-2022-101-12-1555-1561 https://elibrary.ru/lqegtq (in Russian)
  6. Mazhaeva T.V., Dubenko S.E. Nutriative support strategy in the catering of preschool children with the food intolerance. Industriya pitaniya. 2023; 8(2): 31–41. https://doi.org/10.29141/2500-1922-2023-8-2-4 https://elibrary.ru/ecudjg (in Russian)
  7. Plotnikova I.A. An Integrated Approach to Assessing the State of Health and the Effectiveness of Rehabilitation Measures in Children Living Under Exposure to Adverse Environmental Factors: Diss. Ekaterinburg; 2011. (in Russian)
  8. Borodulina T.V., Sannikova N.E., Levchuk L.V., Tiunova E.Yu., Krylova L.V., Krasilova A.V., et al. Fundamentals of Child and Adolescent Health: A Guide for Physicians. Part 1: Comprehensive Assessment of Health of Children and Adolescents [Osnovy zdorov’ya detey i podrostkov: rukovodstvo dlya vrachey. Chast’ I. Kompleksnaya otsenka zdorov’ya detey i podrostkov]. Ekaterinburg; 2017. (in Russian)
  9. Nasybulina G.M., Kocheva N.O., Sannikova N.E., Vakhlova I.V., Babina R.T. Assessment of Physical Development of Children Aged 0 to 16 Years in the Sverdlovsk Region: Guidelines [Otsenka fizicheskogo razvitiya detey Sverdlovskoy oblasti ot 0 do 16 let: Metodicheskie rekomendatsii]. Ekaterinburg; 2002. (in Russian)
  10. Kalaev V.N., Artyukhov V.G., Nechaeva M.S. Micronucleus test of human oral cavity buccal epithelium: problems, achievement, perspectives. Tsitologiya i genetika. 2014; 48(6): 62–80. https://doi.org/10.3103/S0095452714060061 https://elibrary.ru/ufmpex (in Russian)
  11. Levinski M.V., Kalaev V.N., Butorina A.K. The analysis of the contents of cells with micronuclear in buccal epithelium and the level of serum antibodies among children and adult population living in various areas of city of Kishinev. Kurskiy nauchno-prakticheskiy vestnik «Chelovek i ego zdorov’e». 2008; (2): 11–6. https://elibrary.ru/jwalzh (in Russian)
  12. Sycheva L.P., Byakhova M.M., Zemlyanaya G.M., Kovalenko M.A., Sheremet’eva S.M. Cytogenetic indexes, proliferation and apoptosis in epithelial cells of children with bronchial asthma. Pul’monologiya. 2008; (6): 67–70. https://elibrary.ru/jxgoah (in Russian)
  13. Yurchenko V.V., Krivtsova E.K., Podol’naya M.A., Belyaeva N.N., Malysheva A.G., Dmitrieva R.A., et al. Buccal epithelial micronuclear test in the comprehensive assessment of children’s ecological well-being in Moscow. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2007; 86(6): 83–5. https://elibrary.ru/iirncl (in Russian)
  14. Pilat T.L., Kuz’mina L.P., Izmerova N.I. Detoxification Nutrition [Detoksikatsionnoe pitanie]. Moscow: GEOTAR-Media; 2012. (in Russian)
  15. Sudareva T.V., Cudakova N.A., Ermasheva M.A., Shestakova V.N. Comparative characteristics of indicators of lysozyme activity of saliva in children with and without disabilities. In: Actual Problems of Medicine: Proceedings of the Annual Final Scientific and Practical Conference [Aktual’nye problemy meditsiny: materialy ezhegodnoy itogovoy nauchno-prakticheskoy konferentsii]. Grodno; 2018: 725–8. (in Russian)
  16. Mikirtichan G.L., Kaurova T.V., Ochkur O.K. Compliancy as a medico-social and ethic problem of pediatrics. Voprosy sovremennoy pediatrii. 2012; 11(6): 5–10. https://elibrary.ru/pmkedp (in Russian)
  17. Moreno-Macias H., Romieu I. Effects of antioxidant supplements and nutrients on patients with asthma and allergies. J. Allergy Clin. Immunol. 2014; 133(5): 1237–44. https://doi.org/10.1016/j.jaci.2014.03.020
  18. Shcheplyagina L.A. The secretory immunoglobulin a in formation of local immunity in children. Lechenie i profilaktika. 2016; (3): 49–55. https://elibrary.ru/uphvba (in Russian)
  19. Lesnichenko D.A. Secretory immunoglobulin A levels in individuals allergic to house mites. Meditsinskaya immunologiya. 2017; 19(S): 130. https://elibrary.ru/zbfdov (in Russian)
  20. Donaldson D.M., Roberts R.R., Larsen H.S., Tew J.G. Interrelationship between serum beta-lysin, lysozyme and the antibody-complement system in killing Escherichia coli. Infect. Immun. 1974; 10(3): 657–66. https://doi.org/10.1128/iai.10.3.657-666.1974
  21. Ovsyannikov V.G., Toropkina Yu.E., Kraskevich V.V., Alekseev V.V., Boychenko A.E., Alekseeva N.S., et al. Lysozyme – the frontiers of possibility. Sovremennye problemy nauki i obrazovaniya. 2020; (3): 147. https://doi.org/10.17513/spno.29903 https://elibrary.ru/fteorq (in Russian)

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