On the issue of assessing the blood lipid spectrum in working men of different ages

Cover Page

Cite item

Full Text

Abstract

Introduction. Harmful working conditions contribute to the development of dyslipidemia

Goal — assessment of the blood lipid spectrum in men of different age groups under conditions of occupational stress.

Materials and methods. We analyzed the lipid spectrum of the blood in men aged up to 40 years (groups No. 1, 2 with different work experience, n=22 and n=20) and over 40 years of age (group No. 3, n=20). Assessed working conditions. Nutritional status, diet, physical activity, tobacco smoking, and alcohol consumption were determined.

Result. Working conditions are harmful in terms of tension of 3.2 degrees. Physical activity is insufficient, 47.3% have three meals a day, 52.7% have two meals a day. In groups under 40 years of age with different years of experience, 68.2% and 63.2% are overweight; in people over 40 years old, 55.0% are overweight, class I obesity. at 20.0%. The proportion of smokers is 4.5%, 10.0% and 20.0%. With increasing age and experience, triglycerides increased (from 1.12±0.95 to 1.53±0.94 (p=0.022), total cholesterol (from 5.04±1.22 to 6.31±1.2, p=0.001), low-density lipoproteins (from 3.8±0.98 to 4.83± 1.11, p=0.01) mmol/l; proportions of people with hypertriglyceridemia (from 9.1 to 43.8%), hypercholesterolemia (from 40.9% to 93.7%), high LDL-C (from 47.6 to 93.75%); in subgroup No. 1, 19.0%, No. 2, 33.4% had HDL-C below normal. Lipid atherogenicity increased from 3.34±0.13 to 3.95±0.27 (p=0.031).

Limitations. Men under 40 and over 40 years of age with varying years of experience working in hazardous work conditions.

Conclusion. Hard work with poor nutrition and physical inactivity contributes to atherogenic changes in blood lipids. It is proposed to expand the list of studies to assess the atherogenicity of lipids in trained workers; in people with strenuous work, determine at an earlier age for the prevention of cardiovascular diseases.

Compliance with ethical standards. The work was carried out in accordance with the conclusion of the Ethics Committee of the Volga Research Medical University of the Ministry of Health of Russia, protocol No. 4 dated March 14, 2022.

Patient consent. Each participant of the study (or his legal representative) gave informed voluntary written consent to participate in the study and publish personal medical information in an impersonal form in the journal “Gigiena i Sanitariya (Hygiene and Sanitation, Russian journal)”.

Conribuiton:
Rakhmanov R.S. concept and design of the study, writing the text, responsibility for the integrity of all parts of the article;
Bogomolova E.S. editing, approval of the final version of the article;
Razgulin S.A. participation in the interpretation of results, preparation of the text;
Narutdinov D.A. collection and systematization of primary material;
Antyuganov S.N. collection of literature data;
Kalyuzhny V.E. statistical processing of the material.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship. The work was carried out according to the plan of scientific works of the Federal State Budgetary Educational Institution "PIMU" of the Ministry of Health of the Russian Federation and according to the plan of D.A. Narutdinov's dissertation research.

Received: January 23, 2024 / Revised: February 28, 2024 / Accepted: March 11, 2024/ Published: April 10, 2024

About the authors

Rofail S. Rakhmanov

Volga Research Medical University of the Ministry of Health of Russia

Author for correspondence.
Email: raf53@mail.ru
ORCID iD: 0000-0003-1531-5518

MD, PhD, DSci., Professor, Professor of the Department of Hygiene, Privolzhsky Research Medical University, Nizhny Novgorod, 603950, Russian Federation

e-mail: raf53@mail.ru

Russian Federation

Elena S. Bogomolova

Volga Research Medical University of the Ministry of Health of Russia

Email: olenabgm@rambler.ru
ORCID iD: 0000-0002-1573-3667

MD, PhD, DSci., Professor, Head of the Department of Hygiene, Volga Region Research Medical University, Nizhny Novgorod, 603950, Russian Federation

e-mail: olenabgm@rambler.ru

Russian Federation

Sergey A. Razgulin

Volga Research Medical University of the Ministry of Health of Russia

Email: kafedramk@pimunn.ru
ORCID iD: 0000-0001-8356-2970

MD, PhD, DSci., Professor, Head of the Department of Extreme Medicine, Volga Region Research Medical University, Nizhny Novgorod, 603950, Russian Federation

e-mail: kafedramk@pimunn.ru

Russian Federation

Denis A. Narutdinov

Krasnoyarsk State Medical University named after. prof. V.F. Voino-Yasenetsky

Email: den007-19@mail.ru
ORCID iD: 0000-0002-5438-8755

MD, PhD, lecturer at the Department of Public Health and Healthcare, Krasnoyarsk State Medical University named after. prof. V.F. Voino-Yasenetsky, Krasnoyarsk, 660022, Russian Federation

e-mail: den007-19@mail.ru

Russian Federation

Stepan N. Antyuganov

Volga Research Medical University of the Ministry of Health of Russia

Email: anstep@list.ru
ORCID iD: 0009-0009-3003-3931

MD, PhD, lecturer of the Department of Hygiene, Privolzhsky Research Medical University Nizhny Novgorod, 603950, Russian Federation

e-mail: anstep@list.ru

Russian Federation

Evgeny A. Kalyuzhny

Volga Research Medical University of the Ministry of Health of Russia

Email: eakmail@mail.ru
ORCID iD: 0000-0002-0792-1190

MD, PhD, Associate Professor, Associate Professor of the Department of Normal Physiology named after. N.Yu. Belenkova of the Privolzhsky Research Medical University Nizhny Novgorod, 603950, Russian Federation

e-mail: eakmail@mail.ru

Russian Federation

References

  1. Khasazhanova F.O., Rofeev M.Sh. Frequently meeted risk factors in myocardial infarction in young men with different outcome of the disease. Aktual’nye nauchnye issledovaniya v sovremennom mire. 2019; (10–7): 87–90. https:// elibrary.ru/mnvclc (in Russian)
  2. Bułdak Ł., Marek B., Kajdaniuk D., Urbanek A., Janyga S., Bołdys A., et al. Endocrine diseases as causes of secondary hyperlipidemia. Endokrynol. Pol. 2019; 70(6): 511–9. https://doi.org/10.5603/ep.a2019.0041
  3. Amlaev K.R. Dyslipidemia: epidemiology, clinic, diagnostics, prevention and treatment. Vrach. 2021; 32(5): 16–20. https://doi.org/10.29296/25877305-2021-05-03 https://elibrary.ru/vvthyg (in Russian)
  4. Catapano A.L., Graham I., De Backer G., Wiklund O., Chapman M.J., Drexel H., et al. 2016 ESC/EAS guidelines for the management of dyslipidaemias. Eur. Heart J. 2016; 37(39): 2999–3058. https://doi.org/10.1093/eurheartj/ehw272
  5. Liu J., Bu X., Wei L., Wang X., Lai L., Dong C., et al. Global burden of cardiovascular diseases attributable to hypertension in young adults from 1990 to 2019. J. Hypertens. 2021; 39(12): 2488–96. https://doi.org/10.1097/HJH.0000000000002958
  6. Bubnova M.G., Pernes L.E. Modern principles of atherogenic dyslipidemia management in special groups of patients. CardioSomatika. 2020; 11(1): 6–16. https://doi.org/10.26442/22217185.2020.1.200089 https://elibrary.ru/kxvksv (in Russian)
  7. Mal’ G.S., Smakhtina A.M. Secondary hyperlipidemia: definition, phenotypes and inducing factors. Mezhdunarodnyy zhurnal serdtsa i sosudistykh zabolevaniy. 2021; 9(3): 43–51. https://doi.org/10.24412/2311-1623-2021-32-43-51 (in Russian)
  8. Beygel’ E.A., Kudaeva I.V., Masnavieva I.V. The state of lipid metabolism indicators and the system of peroxidation – antioxidant protection in aluminum production workers with occupational bronchopulmonary pathology. Meditsina truda i promyshlennaya ekologiya. 2023; 63(9): 605–10. https://doi.org/10.31089/1026-9428-2023-63-9-605-610 https://elibrary.ru/fayswf (in Russian)
  9. Barbarash O.L., Sedykh D.Yu., Bykova I.S., Kashtalap V.V., Erlikh A.D. Risk factors, clinical features of the course of myocardial infarction and treatment of young patients based on two hospital registries. Ratsional’naya farmakoterapiya v kardiologii. 2020; 16(2): 250–7. https://doi.org/10.20996/1819-6446-2020-04-01 https://elibrary.ru/vvgvtj (in Russian)
  10. Panev N.I., Evseeva N.A., Filimonov S.N., Korotenko O.Yu., Danilov I.P. A system for predicting the development of coronary heart disease in miners with anthracosilicosis. Meditsina truda i promyshlennaya ekologiya. 2021; 61(6): 365–70. https://doi.org/10.31089/1026-9428-2021-61-6-365-370 https://elibrary.ru/thbfaa (in Russian)
  11. Khasanzhanova F., Tashkenbaeva E. The role of risk factors in the development of unstable variants of angina in young and elderly men with dyslipidemia. Zhurnal biomeditsiny i praktiki. 2023; 1(4): 107–13. https://doi.org/10.26739/2181-9300-2021-4-16 (in Russian)
  12. Novikova R.A., Bokhan N.A., Alekseychik S.E., Pankratova Yu.Yu. Prediction of possible coronary heart disease development in young people depending on risk factors and its prevention. Voennaya meditsina. 2020; (4): 48–55. https://elibrary.ru/ievite (in Russian)
  13. Kukharchuk V.V., Ezhov M.V., Sergienko I.V., Arabidze G.G., Balakhonova T.V., Gurevich V.S., et al. Eurasian association of cardiology (EAC)/ Russian national atherosclerosis society (RNAS, Russia) guidelines for the diagnosis and correction of dyslipidemia for the prevention and treatment of atherosclerosis (2020). Evraziyskiy kardiologicheskiy zhurnal. 2020; (2): 6–29. https://doi.org/10.38109/2225-1685-2020-2-6-29 https://elibrary.ru/ypoqht (in Russian)
  14. Grinshteyn Yu.I., Shabalin V.V., Ruf R.R., Shal’nova S.A., Drapkina O.M. Prevalence of a combination of hypertension and dyslipidemia among the adult population of a large east Siberian region. Kardiovaskulyarnaya terapiya i profilaktika. 2021; 20(4): 19–25. https://doi.org/10.15829/1728-8800-2021-2865 https://elibrary.ru/umvlcq (in Russian)
  15. Yang Y., Zheng Z., Chen Y., Wang X., Wang H., Si Z., et al. A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners. Sci. Rep. 2023; 13(1): 2321. https://doi.org/10.1038/s41598-023-29491-2
  16. Murthy V.L., Reis J.P., Pico A.R., Kitchen R., Lima J.A.C., Lloyd-Jones D., et al. Comprehensive metabolic phenotyping refines cardiovascular risk in young adults. Circulation. 2020; 142(22): 2110–27. https://doi.org/10.1161/CIRCULATIONAHA.120.047689
  17. Mach F., Baigent C., Catapano A.L., Koskinas K.C., Casula M., Badimon L., et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur. Heart J. 2020; 41(1): 111–88. https://doi.org/10.1093/eurheartj/ehz455
  18. Ershova A.I., Al’ Rashi D.O., Ivanova A.A., Aksenova Yu.O., Meshkov A.N. Secondary hyperlipidemias: etiology and pathogenesis. Rossiyskiy kardiologicheskiy zhurnal. 2019; 24(5): 74–81. https://doi.org/10.15829/1560–4071-2019-5-74-81 https://elibrary.ru/gbrzyf (in Russian)
  19. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001; 285(19): 2486–97. https://doi.org/10.1001/jama.285.19.2486
  20. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002; 106(25): 3143–421.
  21. Jovanović J., Šarac I., Jovanović S., Sokolović D., Govedarović N., Jovanović J. The relationship between occupational stress, health status, and temporary and permanent work disability among security guards in Serbia. Int. J. Occup. Saf. Ergon. 2021; 27(2): 425–41. https://doi.org/10.1080/10803548.2019.1579458
  22. Poteryaeva O.N., Usynin I.F. Dysfunctional high-density lipoproteins in diabetes mellitus. Problemy endokrinologii. 2022; 68(4): 69–77. https://doi.org/10.14341/probl13118 https://elibrary.ru/pewlnu (in Russian)
  23. Wong N.K.P., Nicholls S.J., Tan J.T.M., Bursill C.A. The role of high-density lipoproteins in diabetes and its vascular complications. Int. J. Mol. Sci. 2018; 19(6): 1680. https://doi.org/10.3390/ijms19061680
  24. Gurevich V.S., Koziolova N.A., Ezhov M.V., Cergienko I.V., Alieva A.S., Vavilova T.V., et al. Unsolved problems of dyslipidemia and residual cardiovascular risk. Ateroskleroz i dislipidemii. 2022; (1): 31–9. https://doi.org/10.34687/2219-8202.JAD.2022.01.0003 https://elibrary.ru/ogxhdy (in Russian)
  25. Borén J., Chapman M.J., Krauss R.M., Packard C.J., Bentzon J.F., Binder C.J., et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur. Heart J. 2020; 41(24): 2313–30. https://doi.org/10.1093/eurheartj/ehz962
  26. Pasta A., Cremonini A.L., Pisciotta L., Buscaglia A., Porto I., Barra F., et al. PCSK9 inhibitors for treating hypercholesterolemia. Expert. Opin. Pharmacother. 2020; 21(3): 353–63. https://doi.org/10.1080/14656566.2019.1702970
  27. Sivamaruthi B.S., Bharathi M., Kesika P., Suganthy N., Chaiyasut C. The administration of probiotics against hypercholesterolemia: a systematic review. Appl. Sci. 2021; 11(15): 6913. https://doi.org/10.3390/app11156913
  28. Zafiraki V.K., Namitokov A.M., Gilevich I.V., Gradovskaya M.V., Malyarevskaya O.V., Karabakhtsieva K.V. Variety of clinical manifestations of hypertriglyceridemia: a case series. Rossiyskiy kardiologicheskiy zhurnal. 2023; 28(S3): 5545. https://doi.org/10.15829/1560-4071-2023-5545 https://elibrary.ru/oojfqw (in Russian)
  29. Tsygankova O.V., Ozhiganova N.V., Kashtalap V.V., Bayramova S.S., Latyntseva L.D. Hypertriglyceridemia as a multidisciplinary problem of modern medicine. Kompleksnye problemy serdechno-sosudistykh zabolevaniy. 2020; 9(4): 114–23. https://doi.org/10.17802/2306-1278-2020-9-4-114-123 https://elibrary.ru/bzuqlx (in Russian)

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2024 Rakhmanov R.S., Bogomolova E.S., Razgulin S.A., Narutdinov D.A., Antyuganov S.N., Kalyuzhny E.A.



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 37884 от 02.10.2009.