Frequency-dependent variability of pulse wave transit time. Pilot study

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Abstract

The dynamics of the pulse wave (PW) associated with the PW transit time variability (PWTTV) determines the peripheral pulse rate variability, which is used as a surrogate for heart rate variability (HRV). The aim of the work is to analyze the frequency-dependent dynamics of PWTTV and to identify the possible frequency-phase modulation of PW velocity oscillations on the transit from the heart to the soft tissues of the distal parts of the upper extremities. RR-interval recordings and synchronous records of photoplethysmograms of 12 conditionally healthy subjects from the PhysioNet open database were used in this work. Using the Hilbert–Huang transform 3 spectral components of PWTTV and HRV were identified. It was shown that the amplitudes of PWTTV oscillations were many times (up to 8.4 times) smaller than the amplitudes of HRV, and the peaks of PWTTV spectral components were shifted towards higher frequencies than those of HRV. Functional relations between PWTTV and HRV, which can determine the phase modulation of periodic changes in the velocity of propagation of PW, were revealed.

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About the authors

A. A. Grinevich

Institute of Cell Biophysics of Russian Academy of Sciences

Author for correspondence.
Email: grin_aa@mail.ru
Russian Federation, Pushchino

N. K. Chemeris

Institute of Cell Biophysics of Russian Academy of Sciences

Email: nikolai.chemeris@mail.ru
Russian Federation, Pushchino

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2. Fig. 1. Spectra of empirical modes for HRV (a, b, c) and GPPV (d, d, f) and their ratios (g, h, i). Points are medians; dashed curves are the 25th and 75th percentiles; bold solid curves are approximations by Weibull functions (a–e) and 4-parameter sigmoid functions (g–i).

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