Prospects for the use of biochemical markers in placental in-growth

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Abstract

Placental in-growth is a severe obstetric pathology characterized by invasive placentation and associated with a high-risk of life-threatening hemorrhage. Despite the widespread use of instrumental methods of examination, timely diagnosis of placental in-growth is a challenging issue. Here, we reviewed the existing biochemical markers used for early detection and confirmation of placental in-growth, their specificity and sensitivity, and correlation with gestational age. Significant results were found for the following substances: pregnancy-associated plasma protein A (PAPP-A) in the first trimester, alpha-fetoprotein (AFP) and human beta-chorionic gonadotropin (Beta-hCG) in the second trimester, brain natriuretic peptide, antithrombin III, plasminogen activator inhibitor type I, soluble Tie-2 receptor (endothelial cell-specific tyrosine kinase receptor), and soluble vascular endothelial growth factor receptor-2. Our findings support the use of the aforementioned biomarkers as screening method for placental in-growth in medical practice.

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About the authors

Al’fiya G. Yashchuk

Bashkir State Medical University

Email: alfiya_galimovna@mail.ru
ORCID iD: 0000-0003-2645-1662

MD, Dr. Sci. (Med.), Professor

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Il’nur I. Musin

Bashkir State Medical University

Email: ilnur-musin@yandex.ru
ORCID iD: 0000-0001-5520-5845

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Ehdvard A. Berg

Bashkir State Medical University

Email: nucleardeer@gmail.com
ORCID iD: 0000-0002-2028-7796

Assistant Lecturer

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Dar’ya D. Gromenko

Bashkir State Medical University

Author for correspondence.
Email: dasha.gromenko@mail.ru
ORCID iD: 0000-0001-5638-1779

student

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Aliya R. Yanbarisova

Bashkir State Medical University

Email: yanbarisova1999@mail.ru
ORCID iD: 0000-0003-3799-4080

student

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Ivan D. Gromenko

Bashkir State Medical University

Email: z28ivan@mail.ru
ORCID iD: 0000-0001-8582-660X

Assistant Lecturer

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

Ehnzhe F. Berdigulova

Bashkir State Medical University

Email: berdigulova_enzhe@mail.ru
ORCID iD: 0000-0002-5111-0256

student

Russian Federation, 3, Lenin str., Ufa, Republic of Bashkortostan, 450008

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