Decades Long Involvement of THP-1 Cells as a Model for Macrophage Research: A Comprehensive Review
- Authors: Sharma P.1, Venkatachalam K.2, Binesh A.1
-
Affiliations:
- Institute of Fisheries Post Graduate Studies, Tamil Nadu Dr. J. Jayalalithaa Fisheries University (TNJFU)
- nstitute of Fisheries Post Graduate Studies, Tamil Nadu Dr. J. Jayalalithaa Fisheries University (TNJFU)
- Issue: Vol 23, No 2 (2024)
- Pages: 85-104
- Section: Medicine
- URL: https://archivog.com/1871-5230/article/view/644644
- DOI: https://doi.org/10.2174/0118715230294413240415054610
- ID: 644644
Cite item
Full Text
Abstract
Over the years, researchers have endeavored to identify dependable and reproducible in vitro models for examining macrophage behavior under controlled conditions. The THP-1 cell line has become a significant and widely employed tool in macrophage research within these models. Originating from the peripheral blood of individuals with acute monocytic leuke-mia, this human monocytic cell line can undergo transformation into macrophage-like cells, closely mirroring primary human macrophages when exposed to stimulants. Macrophages play a vital role in the innate immune system, actively regulating inflammation, responding to infec-tions, and maintaining tissue homeostasis. A comprehensive understanding of macrophage bi-ology and function is crucial for gaining insights into immunological responses, tissue healing, and the pathogenesis of diseases such as viral infections, autoimmune disorders, and neoplastic conditions. This review aims to thoroughly evaluate and emphasize the extensive history of THP-1 cells as a model for macrophage research. Additionally, it will delve into the significance of THP-1 cells in advancing our comprehension of macrophage biology and their invaluable contributions to diverse scientific domains.
About the authors
Prakhar Sharma
Institute of Fisheries Post Graduate Studies, Tamil Nadu Dr. J. Jayalalithaa Fisheries University (TNJFU)
Email: info@benthamscience.net
Kaliyamurthi Venkatachalam
nstitute of Fisheries Post Graduate Studies, Tamil Nadu Dr. J. Jayalalithaa Fisheries University (TNJFU)
Email: info@benthamscience.net
Ambika Binesh
Institute of Fisheries Post Graduate Studies, Tamil Nadu Dr. J. Jayalalithaa Fisheries University (TNJFU)
Author for correspondence.
Email: info@benthamscience.net
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