In-vitro and In Silico Assessment of Anti-inflammation Properties of Saponarin Extracted from Hordeum Vulgare
- Authors: Boyina R.1, Kosanam S.2, Bhimana S.3, Gudimitla R.4, Duraiswamy D.1
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Affiliations:
- Department of Pharmacology, QIS College of Pharmacy
- Department of Pharmacy Practice,, Sandip Institute of Pharmaceutical Sciences
- Department of Pharmaceutical Biotechnology, QIS College of Pharmacy
- Department of Pharmaceutical Analysis, QIS College of Pharmacy
- Issue: Vol 23, No 1 (2024)
- Pages: 14-20
- Section: Medicine
- URL: https://archivog.com/1871-5230/article/view/644624
- DOI: https://doi.org/10.2174/0118715230284334240101100450
- ID: 644624
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Abstract
Background:Hordeum vulgare, commonly known as Barley grass, is a historically significant cultivated plant with profound implications for societies, agricultural sciences, and human nutrition. It has been valued for both sustenance and its potential medicinal properties
Objective:This study aims to comprehensively investigate the medicinal properties of Hordeum vulgare, focusing on its potential therapeutic benefits and anti-inflammatory properties. Addition-ally, we seek to quantify and compare the phytochemical content of two distinct extracts: Barley Grass Hexane Extract (BGHE) and Barley grass aqueous extract (BGAQ).
Methods:We quantified the phytochemical contents of BGHE and BGAQ and evaluated their anti-inflammatory effects using UV spectroscopy at 560 nm, coupled with the RBC membrane stabilization technique. Subsequently, we conducted in silico studies to assess the in vitro anti-inflammatory potential of Barley grass leaf extracts.
Results:Both BGHE and BGAQ demonstrated significant inhibitory effects on inflammation com-pared to the control group. However, BGHE exhibited superior anti-inflammatory efficacy when compared to BGAQ, suggesting its role as a potential anti-inflammatory agent. In silico studies further supported the anti-inflammatory potential of Barley grass leaf extracts.
Conclusion:Hordeum vulgare, or Barley grass, offers a wealth of health benefits, including anti-inflammatory, anti-diabetic, anti-cancer, antioxidant, anti-acne, and anti-depressant properties. These properties contribute to improved immunity, reduced cardiovascular disorders, and alleviation of fatigue. The distinct extracts, BGHE and BGAQ, both exhibit promising anti-inflammatory capabilities, but BGHE shows better anti-inflammatory activity. This research sheds light on the therapeutic potential of Barley grass, making it a valuable candidate for further exploration in the field of natural medicine.
About the authors
Revathi Boyina
Department of Pharmacology, QIS College of Pharmacy
Author for correspondence.
Email: info@benthamscience.net
Sreya Kosanam
Department of Pharmacy Practice,, Sandip Institute of Pharmaceutical Sciences
Email: info@benthamscience.net
Sasidhar Bhimana
Department of Pharmaceutical Biotechnology, QIS College of Pharmacy
Email: info@benthamscience.net
Raveendra Gudimitla
Department of Pharmaceutical Analysis, QIS College of Pharmacy
Email: info@benthamscience.net
Dhachinamoorthi Duraiswamy
Department of Pharmacology, QIS College of Pharmacy
Email: info@benthamscience.net
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