Biomarkers for Diabetic Nephropathy with a Focus on Kidney Injury Molecule-1 (KIM-1)


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Abstract

Diabetic Nephropathy (DN), with an increasing rate of mortality and morbidity, is considered the main cause of End-Stage Renal Disease (ESRD). A wide spectrum of biomarkers exist for early detection of DN, but they suffer from low specificity and sensitivity, indicating the urgent demand for finding more effective biomarkers. Also, the pathophysiology of tubular damage and its relation to DN are not yet completely understood. Kidney Injury Molecule-1 (KIM-1) is a protein that is expressed at substantially low contents in the kidney under physiological conditions. A number of reports have demonstrated the close relationship between urine and tissue KIM-1 levels and kidney disorders. KIM-1 is known as a biomarker for diabetic nephropathy and renal injury. In this study, we aim to review the potential clinical and pathological roles of KIM-1 in diabetic nephropathy.

About the authors

Fatemeh Khonsha

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biochemistry and
Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Email: info@benthamscience.net

Mohammad Valilo

Department of Biochemistry,
Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Email: info@benthamscience.net

Hamid-Reza Nejabati

Department of Biochemistry and
Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz
University of Medical Sciences, Tabriz, Iran

Email: info@benthamscience.net

Mohammad Rahmati-Yamchi

Department of Biochemistry and
Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Email: info@benthamscience.net

Ali Mota

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biochemistry and
Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Author for correspondence.
Email: info@benthamscience.net

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