Biomarkers for Diabetic Nephropathy with a Focus on Kidney Injury Molecule-1 (KIM-1)
- Authors: Khonsha F.1,2, Valilo M.3, Nejabati H.2,4, Rahmati-Yamchi M.2, Mota A.1,2
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Affiliations:
- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
- Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
- Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
- Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
- Issue: Vol 20, No 1 (2024)
- Section: Medicine
- URL: https://archivog.com/1573-3998/article/view/642944
- DOI: https://doi.org/10.2174/1573399819666230328151108
- ID: 642944
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Abstract
Diabetic Nephropathy (DN), with an increasing rate of mortality and morbidity, is considered the main cause of End-Stage Renal Disease (ESRD). A wide spectrum of biomarkers exist for early detection of DN, but they suffer from low specificity and sensitivity, indicating the urgent demand for finding more effective biomarkers. Also, the pathophysiology of tubular damage and its relation to DN are not yet completely understood. Kidney Injury Molecule-1 (KIM-1) is a protein that is expressed at substantially low contents in the kidney under physiological conditions. A number of reports have demonstrated the close relationship between urine and tissue KIM-1 levels and kidney disorders. KIM-1 is known as a biomarker for diabetic nephropathy and renal injury. In this study, we aim to review the potential clinical and pathological roles of KIM-1 in diabetic nephropathy.
About the authors
Fatemeh Khonsha
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biochemistry andClinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Email: info@benthamscience.net
Mohammad Valilo
Department of Biochemistry,Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Email: info@benthamscience.net
Hamid-Reza Nejabati
Department of Biochemistry andClinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz
University of Medical Sciences, Tabriz, Iran
Email: info@benthamscience.net
Mohammad Rahmati-Yamchi
Department of Biochemistry andClinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Email: info@benthamscience.net
Ali Mota
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biochemistry andClinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Author for correspondence.
Email: info@benthamscience.net
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