Comprehensive Overview of Treponema pallidum Outer Membrane Proteins
- Authors: Wu S.1, Luo L.1, Ye F.1, Wang Y.1, Li D.1
-
Affiliations:
- Department of Laboratory Medicine, West China Hospital of Sichuan University
- Issue: Vol 25, No 8 (2024)
- Pages: 604-612
- Section: Life Sciences
- URL: https://archivog.com/1389-2037/article/view/645698
- DOI: https://doi.org/10.2174/0113892037293502240328042224
- ID: 645698
Cite item
Full Text
Abstract
Treponema pallidum, the causative agent of syphilis, is a sexually transmitted microorganism that exhibits remarkable motility capabilities, allowing it to affect various systems. Despite its structural resemblance to gram-negative bacteria due to its dual-membrane, T. pallidum possesses a lower abundance of outer membrane proteins (OMPs), which enables it to effectively conceal itself. This review presents a comprehensive analysis of the clinical diagnostic potential associated with the OMPs of T. pallidum. Furthermore, the known OMPs in T. pallidum that are responsible for mediating host interactions have been progressively elucidated. This review aims to shed light on the pathogenesis of syphilis, encompassing aspects such as vascular inflammation, chancre self-healing, neuroinvasion, and reinfection. Additionally, this review offers a detailed overview of the current state and prospects of development in the field of syphilis vaccines, with the ultimate goal of establishing a foundation for understanding the pathogenesis and implementing effective prevention strategies against syphilis.
About the authors
Sirui Wu
Department of Laboratory Medicine, West China Hospital of Sichuan University
Email: info@benthamscience.net
Lan Luo
Department of Laboratory Medicine, West China Hospital of Sichuan University
Email: info@benthamscience.net
Fei Ye
Department of Laboratory Medicine, West China Hospital of Sichuan University
Email: info@benthamscience.net
Yuanfang Wang
Department of Laboratory Medicine, West China Hospital of Sichuan University
Email: info@benthamscience.net
Dongdong Li
Department of Laboratory Medicine, West China Hospital of Sichuan University
Author for correspondence.
Email: info@benthamscience.net
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