Research Progress on Extracellular Matrix Involved in the Development of Preeclampsia


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Abstract

:Preeclampsia (PE) is a serious pregnancy complication, and its primary clinical manifestations are gestational hypertension and proteinuria. Trophoblasts are responsible for the basic functions of the placenta during placental development; recent studies have revealed that placental "shallow implantation" caused by the decreased invasiveness of placental trophoblasts plays a crucial role in PE pathogenesis. The interaction between the cells and the extracellular matrix (ECM) plays a crucial role in trophoblast proliferation, differentiation, and invasion. Abnormal ECM function can result in insufficient migration and invasion of placental trophoblasts, thus participating in PE. This article summarizes the recent studies on the involvement of ECM components, including small leucine-rich proteoglycans, syndecans, glypicans, laminins, fibronectin, collagen, and hyaluronic acid, in the development of PE. ECM plays various roles in PE development, most notably by controlling the activities of trophoblasts. The ECM is structurally stable and can serve as a biological diagnostic marker and therapeutic target for PE.

About the authors

Xin Wang

School of Pharmacy, Binzhou Medical University

Email: info@benthamscience.net

Qi Zhang

Department of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences

Email: info@benthamscience.net

Yi Ren

School of Pharmacy, Binzhou Medical University

Email: info@benthamscience.net

Chao Liu

School of Pharmacy, Jining Medical University

Author for correspondence.
Email: info@benthamscience.net

Huijie Gao

School of Pharmacy, Jining Medical University

Author for correspondence.
Email: info@benthamscience.net

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