The Disulfide Bond-Mediated Cyclization of Oral Peptides

  • Autores: Yao C.1, Ye G.2, Yang Q.3, Chen Z.4, Yang M.5
  • Afiliações:
    1. Sino-German Biomedical Center, Hubei Provincial Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology
    2. National Clinical Research Center for Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology
    3. College of Life Sciences, Wuhan University
    4. College of Life Science and Technology, Huazhong University of Science and Technology
    5. Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology
  • Edição: Volume 25, Nº 6 (2024)
  • Páginas: 438-442
  • Seção: Life Sciences
  • URL: https://archivog.com/1389-2037/article/view/645640
  • DOI: https://doi.org/10.2174/0113892037280719231214095428
  • ID: 645640

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Resumo

‘Structure determines function’ is a consensus in the current biological community, but the structural characteristics corresponding to a certain function have always been a hot field of scientific exploration. A peptide is a bio-active molecule that is between the size of an antibody and a small molecule. Still, the gastrointestinal barrier and the physicochemical properties of peptides have always limited the oral administration of peptides. Therefore, we analyze the main ways oral peptide conversion strategies of peptide modification and permeation enhancers. Based on our analysis of the structure of natural oral peptides, which can be absorbed through the gastrointestinal tract, we believe that the design strategy of natural stapled peptides based on disulfide bonds is good for oral peptide design. This cannot only be used to identify anti-gastrointestinal digestive structural proteins in nature but also provide a solid structural foundation for the construction of new oral peptide drugs.

Sobre autores

Chenguang Yao

Sino-German Biomedical Center, Hubei Provincial Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology

Email: info@benthamscience.net

Guoguo Ye

National Clinical Research Center for Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology

Email: info@benthamscience.net

Qin Yang

College of Life Sciences, Wuhan University

Email: info@benthamscience.net

Zhenwang Chen

College of Life Science and Technology, Huazhong University of Science and Technology

Email: info@benthamscience.net

Minghui Yang

Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology

Autor responsável pela correspondência
Email: info@benthamscience.net

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