In Vitro Antibacterial Activity of a Novel Acid-Activated Antimicrobial Peptide against Streptococcus mutans


Дәйексөз келтіру

Толық мәтін

Аннотация

Background:Dental caries is an oral disease associated with infection by microbial biofilm. The metabolic activity of cariogenic bacteria results in a pH decrease in the plaque biofilm, causing tooth demineralization. This acidic environment favors the growth of cariogenic bacteria that are highly resistant to strong acids, which, in turn, produce more acid resulting in a further decrease in the pH of the plaque biofilm. Therefore, the strategy of utilizing the acidic dental plaque microenvironment to prevent and treat dental caries has become a hot research topic in recent years, such as the development of pH-sensitive drug delivery systems.

Aims:Design of a new acid-activated antibacterial peptide.

Objective:To design and synthesis an acid targeted antimicrobial peptide with the GWHHFFHFFHFF sequence.

Methods:Minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) testing confirmed its antibacterial activity. Propidium iodide (PI) staining was used to detect nucleic acid leakage. Determination of anti-biofilm activity by biofilm inhibition assay. A phototoxicity study confirmed the phototoxicity of PPIX-P12.

Results:MIC and MBC testing confirmed that P12 possessed acid-activated anti-Streptococcus mutans activity. Bactericidal kinetic experiments and propidium iodide (PI) staining experiments showed that P12 killed planktonic S. mutans UA159 cells leading to the leakage of nucleic acids in the acidic medium. Moreover, P12 showed acid-activated anti-biofilms at the early and mature biofilm stages. P12 was conjugated with the phototherapeutic agent protoporphyrin IX (PpIX) to construct the protoporphyrin derivative PpIX-P12. In vitro experiments revealed that PpIX-P12 displayed better antibacterial activity in pH 5.5 medium than in pH 7.2 medium.

Conclusion:In conclusion, we designed an acid-activated AMP, which had no antimicrobial activity at neutral pH, but had antimicrobial activity at an acidic pH.

Авторлар туралы

Haixing Lin

Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University

Email: info@benthamscience.net

Runhong Zhou

Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University

Email: info@benthamscience.net

Minna Zhang

Department of Nephrology, Tongren Municipal people’s Hospital

Email: info@benthamscience.net

Ruifeng Huang

Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences,, Southern Medical University

Email: info@benthamscience.net

Cuiqiong Fan

Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University

Email: info@benthamscience.net

Shaofen Zhou

Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University

Email: info@benthamscience.net

Jingnan Qiu

Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences,, Southern Medical University

Email: info@benthamscience.net

Jian He

Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences,, Southern Medical University

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

Әдебиет тізімі

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