Triazolopyrimidine Derivatives: An Updated Review on Recent Advances in Synthesis, Biological Activities and Drug Delivery Aspects


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Abstract

Molecules containing triazolopyrimidine core showed diverse biological activities, including anti-Alzheimer's, anti-diabetes, anti-cancer, anti-microbial, anti-tuberculosis, anti-viral, anti-malarial, anti-inflammatory, anti-parkinsonism, and anti-glaucoma activities. Triazolopyrimidines have 8 isomeric structures, including the most stable 1,2,4-triazolo[1,5- a] pyrimidine ones. Triazolopyrimidines were obtained by using various chemical reactions, including a) 1,2,4-triazole nucleus annulation to pyrimidine, b) pyrimidines annulation to 1,2,4-triazole structure, c) 1,2,4-triazolo[l,5-a] pyrimidines rearrangement, and d) pyrimidotetrazine rearrangement. This review discusses synthetic methods, recent pharmacological actions and drug delivery perspectives of triazolopyrimidines.

About the authors

Ahmed Abdelkhalek

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University

Author for correspondence.
Email: info@benthamscience.net

Mohamed Attia

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University

Email: info@benthamscience.net

Mohammad Kamal

Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Networ, West China Hospital, Sichuan University

Author for correspondence.
Email: info@benthamscience.net

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