电邮这篇文章 SPECIFICITIES OF DETECTION OF FENTANYL DERIVATES IN URINE USING METHODS OF LIQUID AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY
- 作者: Zaikina O.L.1, Shilov V.V.2, Lodyagin A.N.3, Grigor’ev A.M.4
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隶属关系:
- ГКУЗ Ленинградский областной наркологический диспансер, химико-токсикологическая лаборатория
- ФГБОУ ВО «Северо-западный государственный медицинский университет им. И.И.Мечникова» Минздрава России
- ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И.Джанелидзе»
- ГБУЗ МО «Бюро СМЭ», судебно-химическое отделение
- 期: 编号 3 (2016)
- 页面: 41-46
- 栏目: Articles
- ##submission.datePublished##: 28.06.2016
- URL: https://archivog.com/0869-7922/article/view/640977
- DOI: https://doi.org/10.36946/0869-7922-2016-3-41-46
- ID: 640977
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详细
SPECIFICITIES OF DETECTION OF FENTANYL DERIVATES IN URINE USING METHODS OF LIQUID AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY Recently in the Leningrad region, cases of poisoning associated with taking fentanyl derivatives (Carfentanyl, 3-Methylfentanyl) became more frequent. Analytical information about taking those compounds by persons brought to central district hospitals with symptoms of drug intoxication gives rise to certain methodological difficulties that are caused by low concentrations of toxic substances in blood and urine and limited metabolism data. Using methods of liquid and gas chromatography-mass spectrometry (GC-MS and LC-MS / MS), urinary metabolites of fentanyl derivatives were identified. Methods for samples preparation based on liquid-liquid or solid-phase extraction are suggested. It is recommended to use LC-MS/MS methods to detect metabolites and unmodified forms of fentanyl derivatives in blood and urine of patients under examination. Results of the practical application of developed methods are reported.
作者简介
O. Zaikina
ГКУЗ Ленинградский областной наркологический диспансер, химико-токсикологическая лаборатория
编辑信件的主要联系方式.
Email: noemail@neicon.ru
俄罗斯联邦
V. Shilov
ФГБОУ ВО «Северо-западный государственный медицинский университет им. И.И.Мечникова» Минздрава России
Email: noemail@neicon.ru
俄罗斯联邦
A. Lodyagin
ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И.Джанелидзе»
Email: noemail@neicon.ru
俄罗斯联邦
A. Grigor’ev
ГБУЗ МО «Бюро СМЭ», судебно-химическое отделение
Email: noemail@neicon.ru
俄罗斯联邦
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