Synthesis and hypoglycemic activity of new nicotinonitrile-furan molecular hybrids

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Abstract

New hybrid molecules bearing 4-(2-furyl)-1,4-dihydronicotinonitrile and 4-(2-furyl)-1,4,5,6-tetrahydronico- tinonitrile fragments were prepared starting from cyanothioacetamide and furfural. The hypoglycemic activity in dexamethasone-induced diabetes mellitus was investigated in vivo in senile rats. Some compounds revealed hypoglycemic effects superior to that of the reference drug (metformin).

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About the authors

D. A. Tilchenko

Lugansk State Medical University named after St. Luke; Belgorod State National Research University

Email: victor_dotsenko_@mail.ru
Russian Federation, 91045, Lugansk, kv. 50 let Oborony Luganska, 1g; 308015, Belgorod, ul. Pobedy, 85

E. Yu. Bibik

Lugansk State Medical University named after St. Luke; Belgorod State National Research University

Email: victor_dotsenko_@mail.ru
Russian Federation, 91045, Lugansk, kv. 50 let Oborony Luganska, 1g; 308015, Belgorod, ul. Pobedy, 85

V. V. Dotsenko

Kuban State University; North Caucasus Federal University

Author for correspondence.
Email: victor_dotsenko_@mail.ru
Russian Federation, 350040, Krasnodar, ul. Stavropolskaya, 149; 355009, Stavropol, ul. Pushkina, 1

S. G. Krivokolysko

Lugansk State Medical University named after St. Luke; Vladimir Dahl Lugansk State University

Email: victor_dotsenko_@mail.ru
Russian Federation, 91045, Lugansk, kv. 50 let Oborony Luganska, 1g; 91034, Lugansk, kv. Molodezhny, 20A

K. A. Frolov

Lugansk State Medical University named after St. Luke; Vladimir Dahl Lugansk State University

Email: victor_dotsenko_@mail.ru
Russian Federation, 91045, Lugansk, kv. 50 let Oborony Luganska, 1g; 91034, Lugansk, kv. Molodezhny, 20A

N. A. Aksenov

North Caucasus Federal University

Email: victor_dotsenko_@mail.ru
Russian Federation, 355009, Stavropol, ul. Pushkina, 1

I. V. Aksenova

North Caucasus Federal University

Email: victor_dotsenko_@mail.ru
Russian Federation, 355009, Stavropol, ul. Pushkina, 1

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Supplementary files

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2. Fig. 1. Biologically active 1,4-dihydro nicotinonitriles.

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3. Fig. 2. Biologically active hybrid molecules with 2-furyl and 1,4-dihydronicotinonitrile fragments.

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4. Scheme 1. Synthesis of compounds (XX) and (XXI).

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5. Scheme 2. Synthesis of compounds (XXII) and (XXIII).

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6. Fig. 3. Dynamics of changes in body weight of rats against the background of modeling dexamethasone diabetes mellitus with subsequent pharmacocorrection with compounds (XX–XXIII) and the reference drug metformin. The differences in the values in the experimental, control and reference groups are significant in comparison with the intact group (p ≤ 0.05).

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