3-hydroxyquinazoline derivatives, analogues of erastin, induce ferroptosis in colorectal cancer cells
- Authors: Osipov V.N.1, Vartanyan A.A.1, Khochenkov D.A.1, Gusev D.V.1, Fateenkova O.V.2, Khachatryan D.S.3, Borisova L.M.1
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Affiliations:
- N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
- I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)
- National Research Center “Kurchatov Institute”
- Issue: Vol 50, No 5 (2024)
- Pages: 601-611
- Section: Articles
- URL: https://archivog.com/0132-3423/article/view/670789
- DOI: https://doi.org/10.31857/S0132342324050033
- EDN: https://elibrary.ru/LRZRMB
- ID: 670789
Cite item
Abstract
In recent years, significant progress has been achieved in the treatment of patients with colon cancer, but in most cases treatment is accompanied by the development of drug resistance. Recently discovered iron-dependent cell death, ferroptosis, makes it a promissing therapeutic target to reduce the recurrence rates. In this study we have examined the effect of 3-hydoxyquinazoline derivatives on ferroptosis induction in two colon cancer cells HCT-116 and DLD-1. The ferroptotic cell death was identified by the level of lipid peroxidation. The level of lipid peroxidation in HCT-116 cells induced by some compounds approached the activity of the reference drug erastin. This scenario changed significantly when the ferroptosis induction was studied in DLD-1 cells. Two 3-hydroxyquinazoline derivatives induced levels of lipid peroxidation in DLD-1 cells that exceeded those of erastin. The preliminary results obtained suggest that three new compounds can be considered as an antitumor agent for the treatment of colon cancer, and also indicate the prospects of further searching for ferroptosis inducers among 3-hydroxyquinazoline derivatives.
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About the authors
V. N. Osipov
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Author for correspondence.
Email: ovn65@yandex.ru
Russian Federation, Kashirskoe shosse 24, Moscow, 115478
A. A. Vartanyan
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Email: ovn65@yandex.ru
Russian Federation, Kashirskoe shosse 24, Moscow, 115478
D. A. Khochenkov
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Email: ovn65@yandex.ru
Russian Federation, Kashirskoe shosse 24, Moscow, 115478
D. V. Gusev
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Email: ovn65@yandex.ru
Russian Federation, Kashirskoe shosse 24, Moscow, 115478
O. V. Fateenkova
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)
Email: ovn65@yandex.ru
Russian Federation, ul. Trubetskaya 8/2, Moscow, 119991
D. S. Khachatryan
National Research Center “Kurchatov Institute”
Email: ovn65@yandex.ru
Russian Federation, pl. Akad. Kurchatova 1, Moscow, 123182
L. M. Borisova
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Email: ovn65@yandex.ru
Russian Federation, Kashirskoe shosse 24, Moscow, 115478
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