Structural and Functional Features of Ketoso-3-Epimerases and Their Use in Production of D-Allulose

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Abstract

Rare sugars attract more and more attention as safe, low-calorie sweeteners and functional compounds in the food, pharmaceutical and medical industries. The potential of the rare sugar D-allulose has been proven in a large number of theoretical and applied works but the high cost of its production is a limitation factor for its large-scall production. Epimerization reactions of available sugars leading to the production of D-allulose are catalyzed by enzymes consisting the epimerase group, namely, ketose-3-epimerases. The key goals of ongoing studies on the ketose-3-epimerase family enzymes are focused on the exact mechanisms of their work, improvement of the enzymatic activity and stability in order to achieve high efficiency in the production of D‑allulose. The present review summarizes the latest innovative developments in use of ketose-3-epimerases, as well as optimization of the enzymatic processes of D-allulose production. The structural features of the main enzymes used in the production of this rare sugar, variants of molecular modifications of biocatalysts and prospects for the practical use of the enzyme pathways discussed in this work are considered.

About the authors

N. S. Ivanova

Kurchatov Genomic Center – PNPI

Email: shvetsova_sv@pnpi.nrcki.ru
Russia, 188300, Gatchina, mkr. Orlova Roshcha 1

A. A. Kulminskaya

Kurchatov Genomic Center – PNPI; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC “Kurchatov Institute”

Email: shvetsova_sv@pnpi.nrcki.ru
Russia, 188300, Gatchina, mkr. Orlova Roshcha 1; Russia, 188300, Gatchina, mkr. Orlova Roshcha 1

S. V. Shvetsova

Kurchatov Genomic Center – PNPI; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC “Kurchatov Institute”; Peter the Great St. Petersburg Polytechnic University

Email: shvetsova_sv@pnpi.nrcki.ru
Russia, 188300, Gatchina, mkr. Orlova Roshcha 1; Russia, 188300, Gatchina, mkr. Orlova Roshcha 1; Russia, 195251, St. Petersburg, ul. Polytechnicheskaya 29

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