Optical Apparatus of the Eye under Conditions of “Dry” Immersion

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

The studies of the astronauts’ vision show that after space flight various changes can occur in the visual system: flattening of the eyeball, optic disc edema, hyperopic refractive shift, and others. The mechanisms of those changes are being actively studied. Among model experiments simulating aggressive factors of space flight, experiments on modeling microgravity in conditions of “dry” immersion seem to be one of the most promising in terms of studying eye changes. The aim: to evaluate the prospects of using “dry” immersion as a model for studying intraocular changes in space flight conditions. The paper presents data on the evaluation of the eye condition of the test subjects after being in the immersion bath for 5 days (10 subjects) and 21 days (6 subjects). Refraction and dynamic accommodation were evaluated in all subjects using an autorefkeratometer Righton Speedy-i k-model with dynamic accommodation assessment function. The refraction data showed a trend toward a positive refractive shift of 0.11 diopters on average for 5 days of immersion (confidence interval (–0.06)–(+0.28)) and 0.29 diopters for 21 days of immersion (c.i. (–0.28)–(+0.86)); no statistical significance of the differences was confirmed, which may be due to the small number of subjects and the limited power of the statistical criterion. However, the trend requires further investigation. A significant individual variation was shown in the results of accommodation assessment. Preliminary data suggest that “dry” immersion may be a promising model for studying the effects of reduced gravity on the human visual system. Further studies are needed.

Толық мәтін

Рұқсат жабық

Авторлар туралы

M. Gracheva

Institute of Biomedical Problems of the RAS; Institute for Information Transmission Problems (Kharkevich Institute), RAS

Хат алмасуға жауапты Автор.
Email: mg.iitp@gmail.com
Ресей, Moscow; Moscow

O. Manko

Institute of Biomedical Problems of the RAS

Email: mg.iitp@gmail.com
Ресей, Moscow

Әдебиет тізімі

  1. Mader T.H., Gibson C.R., Pass A.F. et al. Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight // Ophthalmology. 2011. V. 118. № 10. P. 2058.
  2. Lee A.G., Mader T.H., Gibson C.R. et al. Space flight-associated neuro-ocular syndrome (SANS) // Eye. 2018. V. 32. № 7. P. 1164.
  3. Lee A.G., Mader T.H., Gibson C.R. et al. Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update // NPJ Microgravity. 2020. V. 6. P. 7.
  4. Wojcik P., Batliwala S., Rowsey T. et al. Spaceflight-Associated Neuro-ocular Syndrome (SANS): a review of proposed mechanisms and analogs // Expert Rev. Ophthalmol. 2020. V. 15. № 4. P. 249.
  5. Kramer L.A., Sargsyan A.E., Hasan K.M. et al. Orbital and intracranial effects of microgravity: findings at 3-T MR imaging // Radiology. 2012. V. 263. № 3. P. 819.
  6. Sater S.H., Natividad G.C., Seiner A.J. et al. MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6° head-down tilt bed rest with and without daily centrifugation // J. Appl. Physiol. 2022. V. 133. № 6. P. 1349.
  7. [Akkomodatsiya: rukovodstvo dlya vrachei] (Accommodation: A guide for physicians). Ed. Katargina L.A. M.: “Aprel’”, 2012. 136 p.
  8. Laurie S.S., Macias B.R., Dunn J.T. et al. Optic disc edema after 30 days of strict head-down tilt bed rest // Ophthalmology. 2019. V. 126. № 3. P. 467.
  9. Laurie S.S., Lee S.M., Macias B.R. et al. Optic disc edema and choroidal engorgement in astronauts during spaceflight and individuals exposed to bed rest // JAMA Ophthalmol. 2020. V. 138. № 2. p. 165.
  10. Laurie S.S., Greenwald S.H., Pardon G.L.P. et al. Optic disc edema and chorioretinal folds develop during strict 6° head‐down tilt bed rest with or without artificial gravity // Physiol. Rep. 2021. Т. 9. № 15. P. e14977.
  11. Hargens A.R., Vico L. Long-duration bed rest as an analog to microgravity // J. Appl. Physiol. 2016. V. 120. № 8. P. 891.
  12. Tomilovskaya E.S., Shigueva T.A., Sayenko D.G. et al. Dry immersion as a ground-based model of microgravity physiological effects // Front. Physiol. 2019. V. 10. P. 284.
  13. Shulzhenko E.B., Vil-Villiams I.F. [Possibility of long term water immersion performance by the method of “dry” immersion] // Kosm. Biol. Aviakosm. Med. 1976. V. 10. № 9. P. 82.
  14. Space Physiology and Medicine: From Evidence to Practice. Eds. Nicogossian A.E., Huntoon C.L., Polk J.D., Williams R.S., Doarn C.R., Schneider V.S. New York: Springer, 2016. 509 p.
  15. Tomilovskaya E.S., Rukavishnikov I.V., Amirova L.E. et al. [21-day dry immersion: design and primary results] // Aviakosm. Ekolog. Med. 2020. V. 54. № 4. P. 5.
  16. Navasiolava N.M., Custaud M.A., Tomilovskaya E.S. et al. Long-term dry immersion: Review and prospects // Eur. J. Appl. Physiol. 2011. V. 111. № 7. P. 1235.
  17. Myagkov A.V., Parfenova N.P., Demina E.I. [Rukovodstvo po meditsinskoi optike. Chast’ 1. Osnovy optometrii] (Manual of medical optics. Part 1. Fundamentals of Optometry). M.: “Aprel’”, 2016. 205 p.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
2. Fig. 1. Data on the assessment of refraction before and after immersion in two experiments: 5-day and 21-day “dry” immersion.

Жүктеу (244KB)
3. Fig. 2. Data on the assessment of the dynamics of accommodation function in three testers from the group of 21-day immersion.

Жүктеу (598KB)
4. Fig. 3. Data on the assessment of the dynamics of accommodation function in one test subject from the group of 21-day immersion before immersion, on the first day after removal from the immersion medium and on the fifth day after removal from the immersion medium. See Fig. 2 for the designations.

Жүктеу (480KB)

© Russian Academy of Sciences, 2024