Comparative assessment of neurotrophic proteins in vibration disease

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Introduction. The problem of health impairment due to the impact of physical factors, including vibration disease (VD), retains medical and social relevance due to the significant specific gravity in the structure of occupational morbidity and high prevalence. Under vibration exposure, the acid-base equilibrium, immune status are disturbed, rheological properties and properties of the neurohumoral system, as well as functional indices of the central and peripheral nervous system change. Neurotrophins are known to play an important role in regulating the development and functioning of the central and peripheral nervous systems. In this regard, research is needed to determine in VD patients the levels of neurospecific proteins, which may serve as one of the markers for tracing changes in the nervous system in workers.

The aim of the study was to identify the peculiarities of changes in neurospecific proteins (BDNF, S100β, and MBP) in the serum of patients with VD of different genesis.

Materials and methods. Serum concentrations of neurotrophic proteins: brain neurotrophic factor — BDNF, S100β protein and myelin basic protein (MBP) were studied by solid-phase enzyme-linked immunoassay.

Results. There was an increase in serum BDNF, S100β protein, and MBP concentrations in persons with VD due to combined exposure to local and general vibration, and an increase in MBP was observed in patients with VD due to exposure to local vibration.

Limitations. The limitations of this work are small groups of employees.

Conclusion. As a result of studies, it can be assumed that in VD due to exposure to combined vibration, changes are observed in the peripheral and central parts of the nervous system, and in VD due to local vibration, disorders seem to be mainly associated with the peripheral nervous system. The general pattern of the revealed disorders in the content of MBP lies in the neurodestructive processes occurring in the nerve fibers in patients with VD, regardless of genesis. Summarizing the above mentioned, the validity of studying the concentration of neurospecific proteins in vibration disease occurring with damaging processes in the nervous tissue should be recognized.

Compliance with ethical standards. All procedures performed in studies involving human participants were in accordance with the ethical standards the 2013 Helsinki declaration and Order No. 200n of the Ministry of Health of the Russian Federation of 01.04.2016 “On Approval of Good Clinical Practice Rules”.

Contribution:
Boklazhenko E.V. — study concept and design, collection and processing of material, statistical processing, writing of text;
Bodienkova G.M. — concept and design of research, collection and processing of material, writing of text, editing.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgment. The work was performed within the framework of funds allocated for the implementation of the state task East-Siberian Institute of Medical and Ecological Research.

Received: April 17, 2024 / Accepted: July 31, 2024 / Published: October 16, 2024

作者简介

Elena Boklazhenko

East-Siberian Institute of Medical and Ecological Research

Email: immun11@yandex.ru

MD, PhD, senior researcher, Laboratory of Immuno-Biochemical and Molecular Genetic Research in Hygiene, East-Siberian Institute of Medical and Ecological Research., Angarsk, 665827, Russian Federation

e-mail: immun11@yandex.ru

Galina Bodienkova

East-Siberian Institute of Medical and Ecological Research

编辑信件的主要联系方式.
Email: noemail@neicon.ru

MD, PhD, DSci., professor, head of the Laboratory of Immuno-Biochemical and Molecular Genetic Research in Hygiene, East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation; Professor, Department of Industrial Ecology and Life Safety, Irkutsk National Research Technical University, Irkutsk, 664074, Russian Federation

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