Individual variability of adaptation of structural elements of the jejunal mucosal membrane under the chronic exposure of pulses of electromagnetic fields

Introduction. Numerous studies in the field of electromagnetobiology, both theoretical and experimental-practical, show pulsed electromagnetic fields (EMF) to be the most biologically active, out of all the variety of electromagnetic influences. They have the ability to realize their effects indirectly through the critical systems of the body, manifesting themselves on the subcellular and cellular levels, leading to changes in homeostasis, and as a consequence to the disruption of complex regulatory and coordination relationships carried out in the whole organism. At the same time, the similar electromagnetic influences, depending on the initial functional state of the organism, can cause adaptive changes, or act as a stimulus for pronounced stress, as a result of which adaptive-adaptive reactions fail to adapt.

Material and methods. In the experiment performed on laboratory male rats, starting from the age of 4 months, there was considered the dynamics of the deviations from the homeostasis condition of the control animals after 5, 7 and 10 months of the exposure to pulses of electromagnetic fields, characterized by the following parameters: density of induced currents of 0.37; 0.7; 0.8; 2.7 kA/m²; frequency of pulses per week, regardless of their fractionality of 50, 100 and 500; duration 15 ÷ 40 nsec

Results. Performed adaptometric analysis of the chronodynamics of morphofunctional correlations between the structural elements of the jejunum mucous membrane made it possible to establish a correlation between the cellular populations of the epithelial-connective tissue complex of the intestinal system of the organism, speaking of it as a single system that takes part not only in the regulation of tissue homeostasis but also reflects the real manifestations of individual variability of reactive, dystrophic and adaptive processes depending on the influencing parameters of the electromagnetic factor, the radiation sources, the intensity and duration of the exposure, revealing the various consequences for the irradiated biological object with their compatibility.

Conclusion. In the course of processing the results of the experiment, there were also established “amplitude-frequency windows”, previously registered under similar conditions for the effects of EMF parameters and for other highly sensitive body systems, such as nervous and endocrine, manifested by the absence of shifts in relation to the control indices and indicating possible manifestations tolerance and/or adaptation of the studied indices to individual parameters and EMF.