Methodical approaches to the application of genes variations as indices of susceptibility in the health risk assessment
- Autores: Shur P.Z.1, Shlyapnikov D.M.1, Kostarev V.G.2, Kiryanov D.A.1, Dolgikh O.V.1, Luzhetskiy K.P.1
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Afiliações:
- Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
- Administration of the Federal Supervision Service for Consumer’s Rights Protection and Human Welfare in the Perm Region
- Edição: Volume 97, Nº 4 (2018)
- Páginas: 369-374
- Seção: METHODS OF HYGIENIC AND EXPERIMENTAL INVESTIGATIONS
- ##submission.datePublished##: 20.10.2020
- URL: https://archivog.com/0016-9900/article/view/640364
- DOI: https://doi.org/10.47470/0016-9900-2018-97-4-369-374
- ID: 640364
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Resumo
The biological characteristics of the organism, including the genetic status, can be taken as the indices of the individual susceptibility. These susceptibility indices can be applied in the health risk assessment if there is shown the probability of the development of disorders induced by the exposure to environmental factors and if their cause-and-effect relationship with the exposure of these factors is proved. To distinguish the indices values of the individual susceptibility to the health risk formation in conditions of the exposure to the environmental and occupational factors it is proposed to perform consecutive identification of the contingents, risk factors and their probable effects; evaluation of the exposure of risk factors, including the use of exposure markers; genetic testing of the risk contingents; the establishment of a cause-effect relation of the likely effects (responses) with the exposure of these factors; modeling of the dependence of the probable effects (responses) on the exposure of the studied factors for subpopulations with different susceptibility indices; the characteristics of the health risk with an assessment of the additional probability (frequency) of the studied effects (responses) in subpopulation with susceptibility indices. When testing the proposed methodological approaches it was established that it is possible to use the CT gene variation FAS as an index of the individual susceptibility to the development of diseases of the upper respiratory tract with inhalation exposure to vanadium, AG gene variation HTR2A index of the individual susceptibility to the forming of feeding redundancy in peroral exposure to chloroform, CT heterozygote gene variation MTHFR index value of the individual susceptibility to the forming of the pathology of the circulatory system (hypertension) under exposure to the noise. The proposed methodological approaches for the assessment of the individual health risk associated with the exposure to the environmental factors allow more exactly defining the results of the health risk assessment for the individuals with genotype variations that do the conditioning of the excessive individual susceptibility.
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Sobre autores
Pavel Shur
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Autor responsável pela correspondência
Email: shur@fcrisk.ru
ORCID ID: 0000-0001-5171-3105
MD, Ph.D., DSci., academic secretary of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, , Perm, 614045, Russian Federation.
e-mail: root@fcrisk.ru
RússiaD. Shlyapnikov
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: noemail@neicon.ru
ORCID ID: 0000-0002-3532-3630
Rússia
V. Kostarev
Administration of the Federal Supervision Service for Consumer’s Rights Protection and Human Welfare in the Perm Region
Email: noemail@neicon.ru
ORCID ID: 0000-0001-5135-8385
Rússia
D. Kiryanov
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: noemail@neicon.ru
ORCID ID: 0000-0002-5406-4961
Rússia
O. Dolgikh
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: noemail@neicon.ru
ORCID ID: 0000-0003-4860-3145
Rússia
K. Luzhetskiy
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: noemail@neicon.ru
ORCID ID: 0000-0003-0998-7465
Rússia
Bibliografia
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