Evaluation of the dependence of autoantibody levels and cytokines from the inhalation load of priority toxicants air environment

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

Air pollution has a negative impact on the human body, creating the preconditions for the formation of adaptive processes or the occurrence of pathologies. Formaldehyde, particulate matter, nitrogen oxide were proved to have an effect on the respiratory and immune systems, the latter played a key role in the formation of adaptive reactions. The purpose of the study was to assess the effect of formaldehyde, nitrogen dioxide and particulate pollutants in the air environment, the maintenance of specific autoantibodies and cytokines by means of a mathematical model. The study included 659 students. In assessing individual inhalation of chemical loadings on an organism of adolescents into account data on the content of impurities in the ambient air, indoor air, information about the organization of educational process and rest pupils, anthropometric and spirometric parameters. The content of interleukin-2 and -10, interferon -alpha and -gamma, level of specific autoantibodies that characterize the state of the immune system and lungs has been studied in adolescents. The content of specific autoantibodies and cytokines depends upon hazard indexes priority pollutants are not linear and varies depending on the level of exposure of toxicants. The levels of autoantibodies to β2- glycoprotein I and the content of α-INF and γ-INF adolescents living in air pollution by formaldehyde, nitrogen dioxide, and particulate matter may depend on the level of inhaled pollutants load by 8-11%. Inhalation of nitrogen dioxide in the organism of adolescents may contribute to the variable level of autoantibodies to the of membrane antigens lung parenchyma to 22%.

Авторлар туралы

Liudmila Masnavieva

East-Siberian Institute of Medical and Ecological Research

Хат алмасуға жауапты Автор.
Email: Masnavieva_Luda@mail.ru
ORCID iD: 0000-0002-1400-6345

Ph.D., senior researcher of immuno-biochemical and molecular-genetic researches in hygiene of East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation.

e-mail: Masnavieva_Luda@mail.ru

Ресей

I. Kudaeva

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5608-0818
Ресей

N. Efimova

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0001-7218-2147
Ресей

Әдебиет тізімі

  1. D’Amato G., Liccardi G., D’Amato M., Holgate S. Environmental risk factors and allergic bronchial asthma. Clin.Exp Allergy. 2005; 35 (9): 1113-24.
  2. Medzhitov R., Janeway C. Innate immuniry. N. Engl. J. Med. 2000; (43): 338-44.
  3. Revich B.A. By definition the list of priority contaminants in the environment of Russian cities. Toksikologicheskij vestnik. 2002, 5, pp. 6-12. (in Russian)
  4. Geraghty P., Dabo A.J., D’Armiento J. TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease. J. Biol. Chem. 2011; 286 (34): 30211-18.
  5. Hajat A., Allison M., Diez-Roux A.V., Jenny N.S., Jorgensen N.W., Szpiro A.A., et al. Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation: a repeat-measures analysis in the Multi-Ethnic Study of Atherosclerosis (MESA). Epidemiology. 2015; 26 (3): 310-20.
  6. Wei H., Tan K.,Sun R., Yin L., Zhang J, Pu Y. Aberrant Production of Th1/Th2/Th17-Related Cytokines in Serum of C57BL/6 Mice after Short-Term Formaldehyde Exposure. Int J Environ Res Public Health. 2014; 11 (10): 10036-50.
  7. Mikhylova I.V., Smolyagin A.I., Krasikov S.I., Karaulov A.V. Impact of benzene on the immune system and some of the mechanisms of its action. Immunologiya. 2014; 35 (1): 51-5. (in Russian)
  8. Poletaev A.B. New approaches to early detection of pathological changes in the human body (natural autoantibodies and problems of nanomedicine). Metodicheskie rekomendacii dlja vrachej. Moscow: Immunkulus; 2011. (in Russian)
  9. Mostafavi N., Vlaanderen J., Chadeau-Hyam M., Beelen R., Modig L.,Palli D., Bergdahl I.A.[et al.]. Inflammatory markers in relation to long-termair pollution. Environ Int. 2015; 81: 1-7.
  10. Vitkovsky Yu., Klimenko O. Nitric oxide, cytokines and haemostasis in stroke. Thrombosis and Haemostasis -Suppl. 2003: 0981.
  11. Masnavieva L.B., Efimova N.V., Kudaeva I.V. Individual risks of adolescent health to air pollution, and their relationship with the levels of specific autoantibodies. Gigiena i sanitarija. 2016; (8): 738-43. (in Russian)
  12. Human Health Risk Assessment from Environmental Chemicals. P 2.1.10.1920-04. - Moscow: Federal’nyj centr gossanjepidnadzora Minzdrava Rossii, 2004: 143. (in Russian)
  13. Dorogova V.B., Rukavishnikov V.S., Zhurba O.M., Shajahmetov S.F. Photometric analysis of pollutants in air. Irkutsk: Irkutskij nauchnyj centr hirurgii i travmatologii; 2016: 155. (in Russian)
  14. Liseckaja L.G., Dedkova L.A., Tihonova I.V., Taranenko N.A. Degree assessment of pollution and pathology of upper respiratory tract in teenagers of urbanized territories of Irkutsk region. Bjulleten’ Vostochno-Sibirskogo nauchnogo centra Sibirskogo otdelenija Rossijskoj akademii medicinskih nauk. 2013; 91 (3-1): 91-5. (in Russian)
  15. Kozlov V.S., Shilenkova V.V., Chistjakova O.D. The role of inflammation in the pathogenesis respiratory diseases. Consilium Medicum. 2003; 5 (10): 255-73. (in Russian)
  16. Karaulov A.V. Dysfunction of the immune system in respiratory diseases. Do we need immunomodulators in frequently ailing children? Voprosy sovremennoj pediatrii. 2015: 14 (2): 260-4. (in Russian)

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© Masnavieva L.B., Kudaeva I.V., Efimova N.V., 2024



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