Assessment of the efficiency of prevention of chronic fluorine intoxication with Rhodiola Rosea L. adaptogen

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

Introduction. Fluorine and its compounds are industrial pollutants that cause the development of chronic fluorine intoxication (CFI) during long-term intake. It has been shown that in CFI there are disturbances in metabolic processes and morphological changes in various organs. Therefore, the search for organ protective prevention and correction of damage caused by CFI remains relevant in occupational health and medicine. The perspective direction is the assessment of the possibility of prevention and correction of CFI related disorders by means of the remedies of plant origin possessing adaptogenic action, one of which is Rhodiola Rosea L.

The objective of the research. To evaluate the effectiveness of organ protective prevention of chronic fluoride intoxication with an adaptogenic drug-containing Rhodiola Rosea L in the experiment conditions

Material and methods. The work was carried out on 45 white male rats weighing 200-250 g. Animals were divided into groups of 15 animals: control rats; rats with chronic exposure to sodium fluoride (NaF) for 12 weeks; rats who received NaF solution while administering of Rhodiola Rosea L. extract. Determination of biochemical indices of metabolism in blood serum and histologic studies of the organs (liver and kidneys) were performed.

Results. The use of an adaptogenic drug-containing Rhodiola Rosea L. was shown to be effective in preventing the disorders caused by chronic exposure to fluorine compounds, since it normalizes oxidative metabolism in tissues, reduces the manifestation of degenerative, dystrophic and necrotic changes in the liver and kidneys, restores the synthetic and detoxication functions of the liver, and also preserves the homeostatic function of the kidneys.

Conclusion. The use of an adaptogenic drug-containing Rhodiola Rosea L. for the prevention of damage caused by the chronic effects of fluorine compounds on the body is effective.

Авторлар туралы

N. Mikhailova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of Kemerovo State University

Хат алмасуға жауапты Автор.
Email: noemail@neicon.ru
Ресей

Anna Zhukova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of Kemerovo State University

Email: nyura_g@mail.ru
ORCID iD: 0000-0002-4797-7842

MD, Ph.D., DSci., head of the Laboratory of molecular-genetic and experimental researches, Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation.

e-mail: nyura_g@mail.ru

Ресей

L. Gorokhova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of Kemerovo State University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0545-631X
Ресей

M. Bugaeva

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0003-3692-2616
Ресей

T. Yadykina

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0001-7008-1035
Ресей

A. Kiseleva

Novokuznetsk Clinical Oncology Dispensary

Email: noemail@neicon.ru
Ресей

Әдебиет тізімі

  1. Agalakova N.I., Gusev G.P. Effect of inorganic fluoride on living organisms of different phylogenetic level. Zhurnal evolyutsionnoy biokhimii i fiziologii. 2011; 47(5): 337-47. (in Russian)
  2. Roslaya N.A., Likhachyova E.I., Oransky I.E., Odinokaya V.A., Plotko E.G., Zhovtyak E.P. et al. Clinical and pathogenetic aspects of the chronic occupational intoxication with fluorine compounds in modern reality. Meditsina truda i promyshlennaia ekologiia. 2012; (11): 17-22. (in Russian)
  3. Zhou Z., Wang H., Zheng B. et al. A rat experimental study of the relationship between fluoride exposure and sensitive biomarkers. Biol Trace Elem Res. 2017; Published online: 12 March 2017. https://doi.org/10.1007/S12011-017-0984-4
  4. Barbier O., Arreola-Mendoza L., Del Razo L.M. Molecular mechanisms of fluoride toxicity. Chem Biol Interact. 2010; 188(2): 319-33. https://doi.org/10.1016/j.cbi.2010.07.011.
  5. Chouhan S., Lomash V., Flora S.J. Fluoride-induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats. J. Appl. Toxicol. 2010; 30(1): 63-73. https://doi.org/10.1002/jat.1474
  6. Mikhailova N.N., Zakharenkov V.V., Bugaeva M.S., Bondarev O.I., Kazitskaya A.S., Kizichenko N.V. et al. Specificity of morphologic changes in target organs associated with exposure to coal rock dust and fluorine compounds. Meditsina truda i promyshlennaia ekologiia. 2016; (5): 11-5. (in Russian)
  7. Basha M.P., Sujitha N.S. Chronic fluoride toxicity and myocardial damage: antioxidant offered protection in second generation rats. Toxicol. Int. 2011; 18(2): 99-104. https://doi.org/10.4103/0971-6580.84260
  8. Ulanova E.V., Mikhailova N.N., Danilov I.P., Anokhina A.S., Fomenko D.V., Kizichenko N.V. A method for the prevention of chronic fluoride osteopathy in the modeling fluoride intoxication in the experiment. Patent RF N 2300374; 2007. (in Russian)
  9. Krasnov Ye.A. Flora of the Siberia is the source of biologically active preparations and drugs. Byulleten’ sibirskoy meditsiny. 2006; (Suppl. 2): 11-8. (in Russian)
  10. Panossian A., Wikman G. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity. Pharmaceuticals. 2010; 3(1): 188-224. https://doi.org/10.3390/ph3010188
  11. Vasant R.A., Narasimhacharya A.V. Ameliorative effect of Tamarind leaf on fluoride-induced metabolic alterations. Environ Health Prev Med. 2012; 17(6): 484-93. https://doi.org/10.1007/s12199-012-0277-7
  12. Wiegant F.A., Limandjaja G., de Poot S.A.H. et al. Plant adaptogens activate cellular adaptive mechanisms by causing mild damage. In: Lukyanova L., Takeda N., Singal P.K., eds. Adaptation Biology and Medicine: Health Potentials. Vol. 5. New Delhi: Narosa Publishers; 2008: 319-32.
  13. Panossian A., Wikman G., Kaur P., Asea A. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine. 2009; 16 (6-7): 617-22. https://doi.org/10.1016/j.phymed.2008.12.003
  14. Alekhina D.A., Zhukova A.G., Sazontova T.G. Low dose of fluoride influences to free radical oxidation and intracellular protective systems in heart, lung and liver. Tekhnologii zhivykh sistem. 2016; 13(6): 49-56. (in Russian)
  15. Zhukova A.G., Gorokhova L.G., Kiseleva A.V., Sazontova T.G., Mikhailova N.N. Experimental study of the impact of low fuorine concentrations on the tissue level of HSP family proteins. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2018; 97(7): 604-8. https://doi.org/10.18821/0016-9900-2018-97-7-604-608 (in Russian)
  16. Mikhailova N.N., Zhukova A.G., Gorokhova L.G., Kizichenko N.V., Bugaeva M.S. A method of preventing chronic fluoride intoxication when modeling in the experiment. Patent RF N 2673488; 2018. (in Russian)
  17. Garcia-Montalvo E.A., Reyes-Pérez H., Del Razo L.M. Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress. Toxicology. 2009; 263(2-3): 75-83. https://doi.org/10.1016/j.tox.2009.06.008
  18. Bergandi L., Aina V., Garetto S., Malavasi G., Aldieri E., Laurenti E. et al. Fluoride-containing bioactive glasses inhibit pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human osteoblasts. Chem Biol Interact. 2010; 183(3): 405-15. https://doi.org/10.1016/j.cbi.2009.11.021
  19. He Y.Q., Pan Y., Ying L.J., Zhao R. Differential expression ESTs associated with fluorosis in rats liver. Comparative and Functional Genomics. 2012; 2012: Article ID 208390, 7 pages. https://doi.org/10.1155/2012/208390
  20. Pereira H.A.B.dS., Leite A.dL., Charone S., Lobo J.G.V.M., Cestari T.M., Peres-Buzalaf C. et al. Proteomic analysis of liver in rats chronically exposed to fluoride. PLOS ONE. 2013; 8(11): e75343. https://doi.org/10.1371/journal.pone.0075343
  21. Andreeva L.I., Boikova A.A., Nikiforova D.V. Evaluating adaptogenic properties of Rhodiola rosea extract in human mononuclear cell culture and rat tissues. Eksperimental’naya i klinicheskaya farmakologiya. 2013; 76(2): 23-7. (in Russian)
  22. Chen Q., Wang Z., Xiong Y., Xue W., Kao X., Gao Y. et al. Selenium increases expression of HSP70 and antioxidant enzymes to lesser oxidative damage in Fincoal-type fluorosis. J. Toxicol. Sci. 2009; 34(4): 399-405.
  23. Chattopadhyay A., Podder S., Agarwal S. Fluoride-induced histopathology and synthesis of stress protein in liver and kidney of mice. Arch Toxicol. 2010; 85(4): 327-35.
  24. Andreeva L.I., Boikova A.A., Margulis B.A. Peculiarities of intracellular content and functional role of heat shock proteins 70 kDa under stress and adaptation. Tekhnologii zhivykh sistem. 2009; 6(3): 11-7. (in Russian)
  25. Evdonin A.L., Medvedeva N.D. The extracellular heat shock protein 70 and its functions. Tsitologiya. 2009; 51(2): 130-7. (in Russian)
  26. Kola B., Boscaro M., Rutter G.A., Grossman A.B., Korbonits M. Expanding role of AMPK in endocrinology. Trends Endocrinol. Metab. 2006; 17(5): 205-15. https://doi.org/10.1016/j.tem.2006.05.006
  27. Huang S.C., Lee F.T., Kuo T.Y., Yang J.H., Chien C.T. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. Chin. J. Physiol. 2009; 52 (5): 316-24.
  28. Putker M., Madl T., Vos H.R., de Ruiter H., Visscher M., van den Berg M.C. et al. Redox-dependent control of FOXO/DAF-16 by transportin-1. Mol. Cell. 2013; 49(4): 730-42. https://doi.org/10.1016/j.molcel.2012.12.014
  29. Webb A.E., Kundaje A., Brunet A. Characterization of the direct targets of FOXO transcription factors throughout evolution. Aging Cell. 2016; 15 (4): 673-85. https://doi.org/10.1111/acel.12479
  30. Sun X., Chen W.D., Wang Y.D. DAF-16/FOXO transcription factor in aging and longevity. Front. Pharmacol. 2017; 8: 548. https://doi.org/10.3389/fphar.2017.00548 eCollection 2017.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Mikhailova N.N., Zhukova A.G., Gorokhova L.G., Bugaeva M.S., Yadykina T.K., Kiseleva A.V., 2019


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 37884 от 02.10.2009.