Evaluation of the toxicity of 4-chlorobenzoic acid as the basis of its hygienic rating

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Introduction. One of the effective ways to ensure the chemical safety of workers is the hygienic rating of chemicals in the air of the working area.

Materials and methods. In order to ration, the toxicity indices of 4-chlorobenzoic acid (CBA) were studied. Experimental hygienic studies were conducted on outbred white rats and mice, rabbits and guinea pigs. The functional state of the organs of white rats was assessed on the base of a number of biochemical, physiological, hematological, and morphological indices. The indices of acute inhalation CBA toxicity were determined during the experiment in the seed chambers, the concentration of the substance was adjusted using the spectrophotometric method. Statistical processing of the data obtained was made by using the program “Statistics 10.0”.

Results. The average lethal dose of 4-chlorobenzoic acid when administered orally for mice of both sexes and female rats acconted for of 1.450, 1.100, and 4.300 mg/kg respectively. Mice were more sensitive to CBA, the coefficient of species differences is of 3.9. 4-Chlorobenzoic acid does not have a local irritant effect on the skin and does not have a skin-resorptive effect. Irritant effect on the mucous membranes of the eyes is poor. The ability to material accumulation in the body of CBA is moderate: the cumulation coefficient amounts to 4.7. The ability of a substance to cause allergic responses in the study was not detected. In the subacute experiment, it has a toxic effect mainly on the hepatorenal system. The threshold of acute inhalation action accounts for 50 mg/m3.

Conclusion. 4-Chlorobenzoic acid in terms of average lethal doses belongs to the group of moderately hazardous substances (III class of danger). A tentative safe level of exposure to CBA in the air of the working area is recommended at 1 mg/m3. Compliance with this standard will minimize the risk to the health of workers.

Sobre autores

Larisa Gorokhova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of the Kemerovo State University

Autor responsável pela correspondência
Email: ponomarikova@mail.ru
ORCID ID: 0000-0002-0545-631X

MD, Ph.D., leading researcher of the Laboratory of molecular-genetic and experimental researches of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation.

e-mail: ponomarikova@mail.ru

Rússia

N. Mikhailova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of the Kemerovo State University

Email: noemail@neicon.ru
ORCID ID: 0000-0002-1127-6980
Rússia

Bibliografia

  1. Izmerov N.F., Bukhtiyarov I.V., Prokopenko L.V., Shigan E.E. Russian Federation implementation of WHO global efforts plan on workers health care. Meditsina truda i promyshlennaia ekologiia. 2015; (9): 4-10. (in Russian)
  2. Gorokhova L.G., Martynova N.A., Kizichenko N.V., Logunova T.D. Hygienic aspects of health status of the workers in chemical and pharmaceutical production. Meditsina v Kuzbasse. 2017; 16(3): 11-6. (in Russian)
  3. Gorokhova L.G., Ulanova E.V., Shavtsova G.M., Erdeeva S.V., Blazhina O.N. Health state of workers in chemical and pharmaceutic industry. Meditsina truda i promyshlennaia ekologiia. 2018; (6): 38-42. (in Russian). https://doi.org/10.31089/1026-9428-2018-6-38-42
  4. Rakhmanin Yu.A. Actualization of methodological problems of reglamentation of chemical pollutions on the environment. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2016; 95(8): 701-7. (in Russian). https://doi.org/10.18821/0016-9900-2016-95-8-701-707
  5. Rakhmanin Yu.A. Conceptual and methodological aspects of hygiene as the basis for the development of preventive health care. Russian Journal of Rehabilitation Medicine. 2017; (1): 57-78. (in Russian)
  6. Meshchakova N.M., Shayakhmetov S.F., Dyakovich M.P. The improvement of methodical approaches to the health risk assessment in workers exposed to the chemical factor. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2017; 96(3): 270-4. (in Russian). https://doi.org/10.18821/0016-9900-2017-96-3-270-274
  7. Popova A.Yu., Gurvich V.B., Kuzmin S.V., Mishina A.L., Yarushin S.V. Modern issues of the health risk assessment and management. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2017; 96(12): 1125-9. (in Russian). https://doi.org/10.18821/0016-9900-2017-96-12-1125-1129
  8. Bukhtiyarov I.V., Denisov E.I., Lagutina G.N., Pfaf V.F., Chesalin P.V., Stepanyan I.V. Criteria and algorithms of work-relatedness assessment of workers’ health disorders. Meditsina truda i promyshlennaia ekologiia. 2018; (8): 4-12. (in Russian). https://doi.org/10.31089/1026-9428-2018-8-4-12
  9. Rakhmanin Yu.A., Sinitsyna O.O. Status and update tasks for improving the scientific and methodological and regulatory frameworks in the field of human ecology and environmental hygiene. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2013; 92(5): 4-10. (in Russian)
  10. Martynova N.A., Zakharenkov V.V., Oleshchenko A.M., Gorokhova L.G. Hygienic standardization of 2-formylphenoxyethane acid in the air of working zone. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2016; 95(7): 633-6. (in Russian). https://doi.org/10.18821/0016-9900-2016-95-7-633-636
  11. Gorokhova L.G., Martynova N.A., Kizichenko N.V., Logunova T.D. Hygienic aspects of health status of the workers in chemical and pharmaceutical production. Meditsina v Kuzbasse. 2017; (3): 11-6. (in Russian)
  12. Shtabskiy B.M., Gzhegotskiy M.R., Shafran L.M. Elements of a systematic approach to hygienic regulation of xenobiotics. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2016; 95(3): 311-5. (in Russian). https://doi.org/10.18821/0016-9900-2016-95-3-311-315
  13. Rusakov N.V. Methodological problems of noninfectious epidemiology and hygiene under chemical pollution of the environment. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2016; 95(9): 797-800. (in Russian). https://doi.org/10.18821/0016-9900-2016-95-9-797-800
  14. Sosedova L.M. Experimental models in the system of chemical safety of workers. In: Public health and the environment: Materials of the All-Russian conference. [Zdorov’ye naseleniya i okruzhayushchaya sreda: Materialy Vserossiyskoy konferentsii]. Irkutsk; 2017: 198-203. (in Russian)
  15. Reiter J., Trinka P., Barta F., Shimig D., Nad’ K., Veretskejne Donat D., Nemet N., Tslementish D., Tempe P., Vago P. Method for Preparing {2-[4-(alpha-phenyl-para-chlorobenzyl)piperazine-1-yl]ethoxy}-acetic Acid and New Intermediate Compounds. Patent RF № 2248974; 2000. (in Russian)
  16. Gorokhova L.G., Sosedova L.M., Martynova N.A. Preclinical study as a basis for hygienic regulation of benzofuran derivatives. Meditsina truda i promyshlennaia ekologiia. 2011; (7): 30-3. (in Russian)
  17. Sosedova L.M., Filippova T.M. The role of biosimulation in human chemical safety system. Ekologiya cheloveka. 2017; (7): 46-52. (in Russian)
  18. Gus’kova T.A., Khokhlov A.L., Romanov B.K., Alyautdin R.N., Sinitsina O.A., Speshilova S.A. et al. Drug safety: from pre-clinic to clinic. [Bezopasnost’ lekarstv: ot dokliniki k klinike]. Moscow-Yaroslavl: OOO «Fotolayf»; 2018. (in Russian)
  19. Gorokhova L.G., Bondarev O.I., Bugaeva M.S. Pathological aspects of chronic poisoning with fluoxetine. Vestnik sudebnoy meditsiny. 2013; 3(2): 35-8. (in Russian)
  20. Tokarev A.N., Engashev S.V. Acute toxicity Delcid. Voprosy normativno-pravovogo regulirovaniya v veterinarii. 2010; (4): 122-4. (in Russian)
  21. Istomin A.V., Rumyantseva L.A., Vetrova O.V., Mikhailov I.G., Fedina I.N. Hygienic safety of a new fertilizer. Zdorov’ye i okruzhayushchaya sreda. 2016; (26): 228-31. (in Russian)
  22. Karkischenko N.N. Classic and alternative models in drug toxicology. Biomeditsina. 2006; (4): 1-23. (in Russian)
  23. Birukova N.P., Rusakov S.V., Napalkova V.V. General principles of preclinical safety evaluation of pharmacological drugs for veterinary use. Veterinarnyy vrach. 2018; (1): 3-9. (in Russian)
  24. Navakatikyan M.A., Platonov L.A. Labyrinth for the study on motor activity of white rats. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 1988; (2): 60-2. (in Russian)
  25. Scheuplein R., Charnley G., Dourson M. Differential sensitivity of children and adults to chemical toxicity. Regulatory Toxicology and Pharmacology. 2002. 35 (3): 429-47.
  26. Boopathy R., Rajesh R.V., Darvesh S., Layer P.G. Human serum cholinesterase from liver pathological samples exhibit highly elevated arylacylamidase activity. Clinica Chimica Acta. 2007. 380 (1-2): 151-6.
  27. Gorokhova L.G., Martynova N.A. Experimental study of fluoxetine hepatotoxicity. In: Modern problems of occupational medicine, hygiene and human ecology: Materials of the XLVI scientific and practical conference with international participation “Hygiene, organization of healthcare and occupational pathology” and the seminar “Actual issues of modern occupational pathology”. [Sovremennyye problemy meditsiny truda, gigiyeny i ekologii cheloveka: Materialy XLVI nauchno-prakticheskoy konferentsii s mezhdunarodnym uchastiyem «Gigiyena, organizatsiya zdravookhraneniya i profpatologiya» i seminara “Aktual’nyye voprosy sovremennoy profpatologii”]. Kemerovo: Primula; 2011: 24-7. (in Russian)
  28. Voloshchuk O.N., Kopylchuk G.P., Buchkovskaia I.M. Activity of the marker liver enzymes under the conditions of toxic hepatitis and alimentary deprivation of protein. Eksperimental’naia i klinicheskaia gastroenterologiia. 2014; (8): 96-100. (in Russian)
  29. Galatenko A.G. Modeling of toxic liver damage in small laboratory animals. In: Modern aspects of sanatorium and resort treatment and rehabilitation at the stages of rendering of medical aid to children and adult population: Materials of the All-Russian scientific and practical conference dedicated to the 60th anniversary of Federal State Institution “The North Caucasus Federal Scientific and Clinical Center” of Federal Medical and Biological Agency of Russia.[Sovremennyye aspekty sanatorno-kurortnogo lecheniya i reabilitatsii na etapakh okazaniya meditsinskoy pomoshchi detskomu i vzroslomu naseleniyu: Materialy Vserossiyskoy nauchno-prakticheskoy konferentsii, posvyashchennoy 60-letiyu Federal’nogo Gosudarstvennogo Uchrezhdeniya “Severo-Kavkazskiy Federal’nyy Nauchno-Klinicheskiy Tsentr” Federal’nogo Mediko-Biologicheskogo Agentstva]. Essentuki; 2017: 158-170. (in Russian)
  30. Levina E.N., Gadaskina I.D., eds. Harmful substances in industry. Organic substances: A handbook. [Vrednyye veshchestva v promyshlennosti. Organicheskiye veshchestva: Spravochnik.]. Leningrad: Khimiya; 1985. (in Russian)

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