Spectrum of esterified fatty acids of the omega-3 and omega-6 in the blood of persons with vibration pathology
- Authors: Zhurba O.M.1, Merinov A.V.1, Alekseenko A.N.1, Kudaeva I.V.1
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Affiliations:
- East-Siberian Institute of Medical and Ecological Research
- Issue: Vol 100, No 12 (2021)
- Pages: 1430-1435
- Section: OCCUPATIONAL HEALTH
- Published: 23.12.2021
- URL: https://archivog.com/0016-9900/article/view/638725
- DOI: https://doi.org/10.47470/0016-9900-2021-100-12-1430-1435
- ID: 638725
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Full Text
Abstract
Introduction. Vibration is one of the leading unfavourable physical factors of the working environment and leads to vibration disease (VD) development. The study of metabolic profiles of markers of fatty acids (FA) metabolism is one of the directions in the early diagnosis of vascular diseases and metabolic syndrome (MS), caused, among other things, by exposure to vibration.
The aim of this work is to study the spectrum of esterified fatty acids of the omega-3 and omega-6 families in the blood of patients with vibration disease (VD) and combination with metabolic syndrome (MS).
Materials and methods. The study involved 66 people, divided into two groups: Group I — 34 patients with an established diagnosis of VD; Group II — 32 patients with an established diagnosis of VD in combination with metabolic syndrome (MS). The levels of esterified forms (EF) of polyunsaturated fatty acids (PUFA) of the ω-3 and ω-6 families in blood plasma samples were determined using the method of gas chromatography-mass spectrometry on an Agilent 7890A gas chromatograph with an Agilent 5975C mass selective detector.
Results. The distribution of quantitative indices of PUFA of the ω-3 and ω-6 families in the examined groups was studied. In VD patients with MS, compared with VD patients, there was a statistically significant increase in the level of eicosapentaenoic, α-linolenic acids of the ω-3 family, the sum of ω-3 PUFAs, γ-linolenic and linoleic acids of the ω-6 family.
Conclusion. The study of the quantitative indices of EF of the families ω-3 and ω-6 in the blood plasma of VD patients with MS showed the levels of ω-6 to be 4.5-5.4 times statistically higher than the levels of ω-3 fatty acids.
Contribution:
Zhurba O.M. — the concept and design of the study, collection of literature data, writing a text, editing, research;
Merinov A.V. — collection of literature data, material processing, statistical analysis, text writing;
Alekseenko A.N. — collection and processing of the material, research;
Kudaeva I.V. — organization of research, justification of the research program, editing.
All co-authors — approval of the final version of the article.
Conflict of interest. The authors declare no conflict of interest.
Acknowledgement. Financing of the work was carried out at the expense of funds allocated for the state assignment of the East-Siberian Institute of Medical and Ecological Research.
Received: September 7, 2021 / Accepted: November, 2021 / Published: December 30, 2021
About the authors
Olga M. Zhurba
East-Siberian Institute of Medical and Ecological Research
Author for correspondence.
Email: zhurba99@gmail.com
ORCID iD: 0000-0002-9961-6408
MD, PhD, senior researcher, Laboratory of analytical ecotoxicology and biomonitoring of the East-Siberian Institution of Medical and Ecological Research, Angarsk, 665827, Russian Federation.
e-mail: zhurba99@gmail.com
Russian FederationAlexey V. Merinov
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0001-7848-6432
Russian Federation
Anton N. Alekseenko
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0003-4980-5304
Russian Federation
Irina V. Kudaeva
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0002-5608-0818
Russian Federation
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