Research and comparative assessment of bioaccumulation and negative effects during chronic inhalation exposure to nano- and microparticles of aluminum oxide in an experiment

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Introduction. In connection with atmospheric air pollution by Al2O3 nanoparticles (NPs), which have physical properties different from microparticles (MPs), it is relevant to identify the key features of the negative impact of Al2O3 NPs during long-term inhalation intake.

The aim of the study. Research and comparative assessment of bioaccumulation and negative effects associated with Al2O3 nano- and microparticles chronic inhalation intake the body in an experiment.

Materials and methods. The physical properties of Al2O3 NPs were studied in comparison with MPs. Using Wistar rats, the distinctive features of bioaccumulation and negative effects associated with chronic inhalation exposure to Al2O3 NPs at a concentration of 0.017 mg/m3 for 180 days were determined.

Results. Al2O3 NPs have a smaller size, larger specific surface area and total pore volume, which contributes to their greater penetrating activity through protective barriers compared to MPs. Due to this, with the same range of biodistribution organs, NPs have a higher degree of bioaccumulation. Exposure to NPs causes redox imbalance, cytolysis, hepatotoxic effect, disruption of the processes of excitation and inhibition of the nervous system, and thrombocytosis. When exposed to MP, less pronounced redox imbalance, cytolysis, and disruption of the process of neurotransmission of excitation were noted. NPs cause pathomorphological changes in the form of inflammation and impaired blood circulation in lung tissues, impaired blood circulation in the brain and liver. When exposed to MP, only the development of an inflammatory process in the lungs was established.

Limitations. The study was carried out only with chronic inhalation exposure to Al2O3 NPs and MPs on Wistar rats.

Conclusion. Al2O3 NPs have more pronounced bioaccumulation, a larger spectrum and degree of manifestation of negative effects in comparison with MPs. It is advisable to use the obtained results to improve the effectiveness of scientific substantiation of recommendations aimed at preventing and minimizing negative health effects associated with chronic inhalation exposure to Al2O3 NPs.

Compliance with ethical standards: the study was carried out in accordance with the European Convention for the Protection of Vertebrate Animals used for Experimental or other Scientific Purposes (ETS No. 123) and the requirements of the Ethics Committee of the Federal Scientific Center for Medical and Preventive Technologies for Public Health Risk Management (protocol No. 3 of 27.03.2018).

Contribution:
Zemlyanova M.A. — the concept and design of the study, processing of the material, editing, statistical processing;
Stepankov M.S. — collection of material, processing of material, writing the text.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study was carried out at the expense of the federal budget.

Received: April 3, 2024 / Accepted: June 19, 2024 / Published: July 17, 2024

 

Авторлар туралы

Mark Stepankov

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Хат алмасуға жауапты Автор.
Email: stepankov@fcrisk.ru
ORCID iD: 0000-0002-7226-7682

MD, junior researcher, postgraduate student of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation

e-mail: stepankov@fcrisk.ru

Ресей

Marina Zemlyanova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies; Perm State National Research University; Perm National Research Polytechnic University

Email: zem@fcrisk.ru
ORCID iD: 0000-0002-8013-9613

MD, PhD, DSci., assistant professor, head of Department of Biochemical and Cytogenetic Diagnostics of Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation; Perm State National Research University, Perm, 614990, Russian Federation; Perm National Research Polytechnic University, Perm, 614990, Russian Federation

e-mail: zem@fcrisk.ru

Ресей

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© Stepankov M.S., Zemlyanova M.A., 2024


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