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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Архив акушерства и гинекологии им. В.Ф. Снегирева</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-8726</issn><issn publication-format="electronic">2687-1386</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">699053</article-id><article-id pub-id-type="doi">10.17816/aog699053</article-id><article-id pub-id-type="edn">OFILBH</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original study articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Original study articles</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Identification of predictors of endometrial pathology recurrence in patients after polypectomy</article-title><trans-title-group xml:lang="ru"><trans-title>Выявление предикторов развития рецидива патологии эндометрия у пациенток после полипэктомии</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>子宫内膜息肉切除术后复发预测因素的识别</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-2767-8995</contrib-id><contrib-id contrib-id-type="spin">7707-5981</contrib-id><name-alternatives><name xml:lang="en"><surname>Khachatryan</surname><given-names>Aznar S.</given-names></name><name xml:lang="ru"><surname>Хачатрян</surname><given-names>Азнар Сааковна</given-names></name><name xml:lang="zh"><surname>Khachatryan</surname><given-names>Aznar S.</given-names></name></name-alternatives><address><country country="AM">Armenia</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Associate Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine), Associate Professor</p></bio><email>aznardoc@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7830-2290</contrib-id><contrib-id contrib-id-type="spin">2925-9948</contrib-id><name-alternatives><name xml:lang="en"><surname>Dobrokhotova</surname><given-names>Yulia E.</given-names></name><name xml:lang="ru"><surname>Доброхотова</surname><given-names>Юлия Эдуардовна</given-names></name><name xml:lang="zh"><surname>Dobrokhotova</surname><given-names>Yulia E.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>pr.dobrohotova@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8155-8775</contrib-id><contrib-id contrib-id-type="spin">5753-4380</contrib-id><name-alternatives><name xml:lang="en"><surname>Ilyina</surname><given-names>Irina Yu.</given-names></name><name xml:lang="ru"><surname>Ильина</surname><given-names>Ирина Юрьевна</given-names></name><name xml:lang="zh"><surname>Ilyina</surname><given-names>Irina Yu.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>д-р мед. наук</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine)</p></bio><email>iliyina@mail.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0677-2952</contrib-id><contrib-id contrib-id-type="spin">2723-5711</contrib-id><name-alternatives><name xml:lang="en"><surname>Narimanova</surname><given-names>Metanat R.</given-names></name><name xml:lang="ru"><surname>Нариманова</surname><given-names>Метанат Рафиговна</given-names></name><name xml:lang="zh"><surname>Narimanova</surname><given-names>Metanat R.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Associate Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine), Associate Professor</p></bio><email>safarovametanat@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Yerevan State Medical University after Mkhitar Heratsi</institution></aff><aff><institution xml:lang="ru">Ереванский государственный медицинский университет им. Мхитара Гераци</institution></aff><aff><institution xml:lang="zh">Yerevan State Medical University after Mkhitar Heratsi</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian National Research Medical University n.a. N.I. Pirogov</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет им. Н.И. Пирогова</institution></aff><aff><institution xml:lang="zh">Russian National Research Medical University n.a. N.I. Pirogov</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Yaroslavl State Medical University</institution></aff><aff><institution xml:lang="ru">Ярославский государственный медицинский университет</institution></aff><aff><institution xml:lang="zh">Yaroslavl State Medical University</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2026-05-07" publication-format="electronic"><day>07</day><month>05</month><year>2026</year></pub-date><pub-date date-type="pub" iso-8601-date="2026-08-11" publication-format="electronic"><day>11</day><month>08</month><year>2026</year></pub-date><volume>13</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>160</fpage><lpage>168</lpage><history><date date-type="received" iso-8601-date="2025-12-22"><day>22</day><month>12</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2026-03-17"><day>17</day><month>03</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-08-11"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://eco-vector.com/for_authors.php#07</ali:license_ref></license></permissions><self-uri xlink:href="https://archivog.com/2313-8726/article/view/699053">https://archivog.com/2313-8726/article/view/699053</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND:</bold> Endometrial polyps are a benign intrauterine condition whose etiology remains unclear. Altered uterine microbiota is one possible contributing factor. Furthermore, recurrence rates after polypectomy remain high, making postoperative management to reduce recurrence a relevant issue.</p> <p><bold>AIM:</bold><bold><italic> </italic></bold>To identify predictors of endometrial pathology recurrence in patients after polypectomy.</p> <p><bold>METHODS:</bold> The study included 147 reproductive-age patients with endometrial polyps who underwent polypectomy. Postoperative hormonal therapy was given to 123 (83.7%) patients, while 24 (16.3%) declined it. We analyzed the association between recurrence and the recommended treatment, and between recurrence and vaginal microflora characteristics.</p> <p><bold>RESULTS:</bold> No patient who received a levonorgestrel-releasing intrauterine system (LNG-IUS) required repeat surgery. Combined oral contraceptive (COC) use reduced the likelihood of hysteroscopy with diagnostic curettage 2.6-fold compared with patients who declined treatment, and cyclic progestogen use reduced it 1.9-fold compared with the observation-only group. Bacterial vaginosis was associated with a 3.4-fold higher reoperation rate than other vaginal microflora states.</p> <p><bold>CONCLUSION:</bold> After polypectomy, to prevent abnormal uterine bleeding, LNG-IUS placement or COC use should be considered for women who need contraception. In addition, timely detection of vaginal dysbiosis during follow-up is important, as it affects the incidence of endometrial proliferative disease.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Полипы эндометрия являются доброкачественной внутриматочной патологией, этиология которой до настоящего времени до конца неизвестна. Одним из возможных факторов развития полипов эндометрия является нарушение микробиоты полости матки. Кроме того, после оперативного удаления полипа эндометрия частота его рецидива остаётся достаточно высокой, поэтому вопрос о необходимости лечения в послеоперационном периоде с целью уменьшения развития рецидива является актуальным.</p> <p><bold>Цель исследования.</bold> Уточнение предикторов развития рецидива патологии эндометрия у пациенток после полипэктомии.</p> <p><bold>Методы.</bold> В исследование включены 147 пациенток репродуктивного периода с полипами эндометрия, которым проводили полипэктомию. В 123 (83,7%) случаях в послеоперационном периоде пациенткам проводили гормональное лечение, в 24 (16,3%) случаях пациентки категорически от него отказались. Проанализировали взаимосвязи между частотой развития рецидива патологии эндометрия и рекомендуемым лечением, а также между частотой рецидива и особенностями микрофлоры влагалища.</p> <p><bold>Результаты.</bold> При использовании левоноргестрел-выделяющей внутриматочной системы не было необходимости в проведении повторного хирургического вмешательства. Применение пациентками комбинированных оральных контрацептивов уменьшало вероятность гистероскопии с раздельным диагностическим выскабливанием по сравнению с пациентками, которые отказались от консервативного лечения, в 2,6 раза, использование гестагенов в циклическом режиме по сравнению с группой, которая находилась под наблюдением, — в 1,9 раза. Результаты исследования показали, что при бактериальном вагинозе частота повторного оперативного лечения в 3,4 раза выше по сравнению с другими состояниями микрофлоры влагалища пациенток.</p> <p><bold>Заключение.</bold> В послеоперационном периоде после полипэктомии с целью профилактики аномальных маточных кровотечений целесообразно рекомендовать введение левоноргестрел-выделяющей внутриматочной системы или приём комбинированных оральных контрацептивов женщинам, нуждающимся в контрацепции. Также в ходе динамического наблюдения за пациентками важно своевременно выявлять дисбиоз влагалища, который оказывает влияние на частоту развития пролиферативных заболеваний эндометрия.</p></trans-abstract><trans-abstract xml:lang="zh"><p>论证。 子宫内膜息肉是良性宫腔内病变，其病因至今尚未完全明确。子宫内膜息肉的可能致病因素之一是宫腔微生态失调。此外，子宫内膜息肉手术切除后复发率仍较高，因此术后为减少复发而进行治疗的问题具有现实意义。</p> <p>目的。 明确子宫内膜息肉切除术后患者子宫内膜病变复发的预测因素。</p> <p>方法。 纳入147例育龄期子宫内膜息肉患者，均接受息肉切除术。术后123例（83.7%）接受激素治疗，24例（16.3%）坚决拒绝治疗。分析了子宫内膜病变复发率与推荐治疗之间的相关性，以及复发率与阴道微生态特征之间的相关性。</p> <p>结果。 使用左炔诺孕酮宫内缓释系统的患者无需再次手术。使用复方口服避孕药的患者与拒绝保守治疗的患者相比，行宫腔镜联合分段诊刮术的概率降低2.6倍；周期性使用孕激素的患者与仅观察组相比降低1.9倍。研究结果显示，细菌性阴道病患者再次手术治疗频率较其他阴道微生态状态患者高3.4倍。</p> <p>结论。 子宫内膜息肉切除术后，为预防异常子宫出血，建议推荐有避孕需求的女性放置左炔诺孕酮宫内缓释系统或服用复方口服避孕药。同时，在患者动态随访中，及时识别阴道菌群失调至关重要，因其对子宫内膜增生性病变的发生率具有影响。</p></trans-abstract><kwd-group xml:lang="en"><kwd>endometrial polyp</kwd><kwd>vaginal microbiota</kwd><kwd>vaginal dysbiosis</kwd><kwd>bacterial vaginosis</kwd><kwd>candidiasis</kwd><kwd>hormonal treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>полип эндометрия</kwd><kwd>микробиота влагалища</kwd><kwd>дисбиоз влагалища</kwd><kwd>бактериальный вагиноз</kwd><kwd>кандидоз</kwd><kwd>гормональное лечение</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>子宫内膜息肉</kwd><kwd>阴道微生态</kwd><kwd>阴道菌群失调</kwd><kwd>细菌性阴道病</kwd><kwd>念珠菌病</kwd><kwd>激素治疗</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bagdasaryan LYu, Ponomarev VV, Penghoyan GA. 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