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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Архив акушерства и гинекологии им. В.Ф. Снегирева</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-8726</issn><issn publication-format="electronic">2687-1386</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">689443</article-id><article-id pub-id-type="doi">10.17816/aog689443</article-id><article-id pub-id-type="edn">HKOFMO</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Correction of vitamin status in pregnant women: current approaches and clinical significance</article-title><trans-title-group xml:lang="ru"><trans-title>Коррекция витаминного статуса у беременных: современные подходы и клиническое значение</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>妊娠期维生素状态的矫正：现代策略及其临床意义</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-4792-4353</contrib-id><name-alternatives><name xml:lang="en"><surname>Sukhanova</surname><given-names>Maria A.</given-names></name><name xml:lang="ru"><surname>Суханова</surname><given-names>Мария Александровна</given-names></name><name xml:lang="zh"><surname>Sukhanova</surname><given-names>Maria A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>suxanovamaria@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-5459-3054</contrib-id><contrib-id contrib-id-type="spin">2275-4803</contrib-id><name-alternatives><name xml:lang="en"><surname>Kiryanova</surname><given-names>Anastasia O.</given-names></name><name xml:lang="ru"><surname>Кирьянова</surname><given-names>Анастасия Олеговна</given-names></name><name xml:lang="zh"><surname>Kiryanova</surname><given-names>Anastasia O.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>Anastasia.kiryanova2002@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6603-804X</contrib-id><contrib-id contrib-id-type="spin">3122-7420</contrib-id><name-alternatives><name xml:lang="en"><surname>Ageev</surname><given-names>Mikhail B.</given-names></name><name xml:lang="ru"><surname>Агеев</surname><given-names>Михаил Борисович</given-names></name><name xml:lang="zh"><surname>Ageev</surname><given-names>Mikhail B.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Assistant Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine), Assistant Professor</p></bio><email>mikhaageev@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2368-1932</contrib-id><contrib-id contrib-id-type="spin">3002-6388</contrib-id><name-alternatives><name xml:lang="en"><surname>Svidinskaya</surname><given-names>Evgeniia A.</given-names></name><name xml:lang="ru"><surname>Свидинская</surname><given-names>Евгения Александровна</given-names></name><name xml:lang="zh"><surname>Svidinskaya</surname><given-names>Evgeniia A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>svidinskaya@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6393-9961</contrib-id><contrib-id contrib-id-type="spin">7667-2482</contrib-id><name-alternatives><name xml:lang="en"><surname>Zemlina</surname><given-names>Natalia S.</given-names></name><name xml:lang="ru"><surname>Землина</surname><given-names>Наталья Сергеевна</given-names></name><name xml:lang="zh"><surname>Zemlina</surname><given-names>Natalia S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>zemlina_n_s@staff.sechenov.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3382-026X</contrib-id><contrib-id contrib-id-type="spin">3366-8200</contrib-id><name-alternatives><name xml:lang="en"><surname>Proklova</surname><given-names>Guzel F.</given-names></name><name xml:lang="ru"><surname>Проклова</surname><given-names>Гюзель Фаритовна</given-names></name><name xml:lang="zh"><surname>Proklova</surname><given-names>Guzel F.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><bio xml:lang="zh"><p>MD</p></bio><email>guzelp@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1732-6870</contrib-id><contrib-id contrib-id-type="spin">6313-9959</contrib-id><name-alternatives><name xml:lang="en"><surname>Sosnova</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Соснова</surname><given-names>Елена Алексеевна</given-names></name><name xml:lang="zh"><surname>Sosnova</surname><given-names>Elena A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>sosnova-elena@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)</institution></aff><aff><institution xml:lang="zh">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-12-10" publication-format="electronic"><day>10</day><month>12</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-12-29" publication-format="electronic"><day>29</day><month>12</month><year>2025</year></pub-date><volume>12</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>381</fpage><lpage>394</lpage><history><date date-type="received" iso-8601-date="2025-08-18"><day>18</day><month>08</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-11-15"><day>15</day><month>11</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-01-09"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://eco-vector.com/for_authors.php#07</ali:license_ref></license></permissions><self-uri xlink:href="https://archivog.com/2313-8726/article/view/689443">https://archivog.com/2313-8726/article/view/689443</self-uri><abstract xml:lang="en"><p>This systematic review aims to summarize current evidence on vitamin deficiencies in pregnant women, their clinical consequences, and approaches to nutritional status correction during gestation. Given the increasing prevalence of hypovitaminosis among pregnant women, particularly deficiencies of folic acid, vitamin D, and vitamin B12, the clinical importance of early diagnosis and individualized therapy is growing. The article analyzes studies published over the past 5 years by Russian and international authors, including randomized controlled trials, meta-analyses, cohort studies, and international clinical guidelines. Key micronutrients, their effects on the course of pregnancy, maternal and fetal outcomes, and factors contributing to impaired vitamin metabolism, including genetic polymorphisms (<italic>MTHFR, VDR, TCN2</italic>), were evaluated. The review presents approaches to laboratory diagnosis of vitamin deficiencies, principles of rational dietary therapy, and the use of vitamin–mineral supplements, as well as the potential of personalized nutritional correction. The need for incorporating vitamin status assessment into preconception care and antenatal management algorithms for women at risk is substantiated. The findings of this review emphasize the role of nutritional support as an essential component in the prevention of obstetric and perinatal conditions.</p></abstract><trans-abstract xml:lang="ru"><p>Целью систематического обзора является обобщение современных данных о дефиците витаминов у беременных женщин, его клинических последствиях и подходах к коррекции нутритивного статуса в период гестации. В условиях растущей распространённости гиповитаминозов среди беременных, особенно в отношении фолиевой кислоты, витаминов D и B12, возрастает клиническая значимость ранней диагностики и индивидуализированной терапии. В статье проанализированы работы отечественных и зарубежных авторов за последние 5 лет, включающие рандомизированные контролируемые исследования, метаанализы, когортные наблюдения и международные рекомендации. Оценивали ключевые микронутриенты, их влияние на течение беременности и исходы для матери и плода, а также факторы, способствующие нарушению метаболизма витаминов, включая генетические полиморфизмы (<italic>MTHFR, VDR, TCN2</italic>). В статье представлены подходы к лабораторной диагностике дефицитов, принципы рациональной диетотерапии и применения витаминно-минеральных комплексов, а также возможности персонализированной нутритивной коррекции. Обоснована необходимость включения оценки витаминного статуса в алгоритмы прегравидарной подготовки и антенатального ведения женщин из групп риска. Результаты обзора подчёркивают роль нутритивной поддержки как важного компонента профилактики акушерской и перинатальной патологии.</p></trans-abstract><trans-abstract xml:lang="zh"><p>本系统综述旨在概述妊娠期女性维生素缺乏的现代研究数据、其临床后果以及在妊娠期矫正营养状态的相关策略。随着孕妇中低维生素状态发生率的不断增加，尤其是在叶酸、维生素D及维生素B12方面，早期诊断与个体化治疗的临床意义日益增强。本文分析了近5年俄罗斯及国外作者的研究成果，包括随机对照研究、荟萃分析、队列观察及国际推荐意见。评估了关键微量营养素对妊娠过程及母婴结局的影响，同时分析了导致维生素代谢障碍的相关因素，包括遗传多态性（MTHFR、VDR、TCN2）。文中介绍了维生素缺乏的实验室诊断方法、合理的膳食治疗原则、维生素-矿物质补充制剂的应用，以及个体化营养矫正的可能性。论证了在孕前准备及高风险孕妇产前管理中纳入维生素状态评估的必要性。综述结果强调，营养支持是预防产科及围产期病理的重要组成部分。</p></trans-abstract><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>vitamins</kwd><kwd>nutrient deficiency</kwd><kwd>folic acid</kwd><kwd>vitamin D</kwd><kwd>nutrigenetics</kwd><kwd>systematic review</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>витамины</kwd><kwd>нутриентный дефицит</kwd><kwd>фолиевая кислота</kwd><kwd>витамин D</kwd><kwd>нутригенетика</kwd><kwd>систематический обзор</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>妊娠</kwd><kwd>维生素</kwd><kwd>营养素缺乏</kwd><kwd>叶酸</kwd><kwd>维生素 D</kwd><kwd>营养遗传学</kwd><kwd>系统综述</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Jouanne M, Oddoux S, Noël A, Voisin-Chiret AS. 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