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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Архив акушерства и гинекологии им. В.Ф. Снегирева</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-8726</issn><issn publication-format="electronic">2687-1386</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">628834</article-id><article-id pub-id-type="doi">10.17816/aog628834</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original study articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Original study articles</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Experience of using transvaginal sclerotherapy in the treatment of ovarian endometriomas</article-title><trans-title-group xml:lang="ru"><trans-title>Опыт применения трансвагинальной аспирационно-пункционной склеротерапии в лечении эндометриом яичников</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>经阴道抽吸穿刺硬化疗法治疗卵巢子宫内膜瘤的经验</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8734-1673</contrib-id><contrib-id contrib-id-type="spin">5452-6728</contrib-id><name-alternatives><name xml:lang="en"><surname>Popov</surname><given-names>Alexander A.</given-names></name><name xml:lang="ru"><surname>Попов</surname><given-names>Александр Анатольевич</given-names></name><name xml:lang="zh"><surname>Popov</surname><given-names>Alexander A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>gyn_endoscopy@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0919-6567</contrib-id><contrib-id contrib-id-type="spin">8635-3094</contrib-id><name-alternatives><name xml:lang="en"><surname>Ovsiannikova</surname><given-names>Maiia R.</given-names></name><name xml:lang="ru"><surname>Овсянникова</surname><given-names>Майя Руслановна</given-names></name><name xml:lang="zh"><surname>Ovsiannikova</surname><given-names>Maiia R.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Postgraduate Student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><bio xml:lang="zh"><p>Postgraduate Student</p></bio><email>maya199529@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6935-6086</contrib-id><contrib-id contrib-id-type="spin">6641-6742</contrib-id><name-alternatives><name xml:lang="en"><surname>Sopova</surname><given-names>Julia I.</given-names></name><name xml:lang="ru"><surname>Сопова</surname><given-names>Юлия Игоревна</given-names></name><name xml:lang="zh"><surname>Sopova</surname><given-names>Julia I.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>rakova_yuliya@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2590-5087</contrib-id><contrib-id contrib-id-type="spin">2598-7181</contrib-id><name-alternatives><name xml:lang="en"><surname>Fedorov</surname><given-names>Anton A.</given-names></name><name xml:lang="ru"><surname>Фёдоров</surname><given-names>Антон Андреевич</given-names></name><name xml:lang="zh"><surname>Fedorov</surname><given-names>Anton A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>д-р мед. наук</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine)</p></bio><email>aa.fedorov@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1873-5676</contrib-id><name-alternatives><name xml:lang="en"><surname>Troshina</surname><given-names>Vlada V.</given-names></name><name xml:lang="ru"><surname>Трошина</surname><given-names>Влада Владимировна</given-names></name><name xml:lang="zh"><surname>Troshina</surname><given-names>Vlada V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Postgraduate Student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><bio xml:lang="zh"><p>Postgraduate Student</p></bio><email>gyn_endoscopy@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5674-1284</contrib-id><contrib-id contrib-id-type="spin">8964-2126</contrib-id><name-alternatives><name xml:lang="en"><surname>Pelshe</surname><given-names>Eyzhena V.</given-names></name><name xml:lang="ru"><surname>Пельше</surname><given-names>Эйжена Валдисовна</given-names></name><name xml:lang="zh"><surname>Pelshe</surname><given-names>Eyzhena V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Research Associate</p></bio><bio xml:lang="ru"><p>научный сотрудник</p></bio><bio xml:lang="zh"><p>Research Associate</p></bio><email>epelshe@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9327-0656</contrib-id><contrib-id contrib-id-type="spin">5098-6945</contrib-id><name-alternatives><name xml:lang="en"><surname>Ershova</surname><given-names>Irina Y.</given-names></name><name xml:lang="ru"><surname>Ершова</surname><given-names>Ирина Юрьевна</given-names></name><name xml:lang="zh"><surname>Ershova</surname><given-names>Irina Y.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>i3236987@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Moscow Regional Research Institute of Obstetrics and Gynecology n.a. Academician V.I. Krasnopolsky</institution></aff><aff><institution xml:lang="ru">Московский областной научно-исследовательский институт акушерства и гинекологии им. акад. В.И. Краснопольского</institution></aff><aff><institution xml:lang="zh">Moscow Regional Research Institute of Obstetrics and Gynecology n.a. Academician V.I. Krasnopolsky</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Moscow Regional Research Clinical Institute n.a. M.F. Vladimirsky</institution></aff><aff><institution xml:lang="ru">Московский областной научно-исследовательский клинический институт</institution></aff><aff><institution xml:lang="zh">Moscow Regional Research Clinical Institute n.a. M.F. Vladimirsky</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-09-09" publication-format="electronic"><day>09</day><month>09</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-10-07" publication-format="electronic"><day>07</day><month>10</month><year>2024</year></pub-date><volume>11</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>322</fpage><lpage>331</lpage><history><date date-type="received" iso-8601-date="2024-03-06"><day>06</day><month>03</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-07-16"><day>16</day><month>07</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2024,</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2026-10-07"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://archivog.com/2313-8726/article/view/628834">https://archivog.com/2313-8726/article/view/628834</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND</bold>: Ethanol sclerotherapy is an effective and a safe surgical treatment method for ovarian endometrioma (OMA). Destruction with 95% ethanol solution of the capsule allows minimal impact on the ovarian reserve. However, this method should be thoroughly evaluated for the possibility to be used more frequently in practice.</p> <p><bold>AIM</bold>: To determine the indications for the use of transvaginal sclerotherapy in surgical treatment of OMA.</p> <p><bold>MATERIAL AND METHODS</bold>: Between October 2021 and October 2023, 17 patients with OMA were operated at the Moscow Regional Research Institute of Obstetrics and Gynecology, with sclerotherapy performed by transvaginal access. Clinical manifestations included pelvic pain (76.4%), dysmenorrhea (82.3%), dyspareunia (47.0%), bowel symptoms (35.3%), polymenorrhea (47.0%), and infertility (64.7%). Eleven (64.7%) of the patients had been previously operated because of ОМА.</p> <p><bold>RESULTS</bold>: Postoperative anti-Mullerian hormone (AMH) levels were slightly reduced (mean difference before and after the surgery was 0.47 ng/ml). The mean antral follicle count in the both ovaries were 10.8 before surgery and 8.6 after surgery. The volume of the ovary decreased from 2 to 6 times after sclerotherapy of the endometrioma. Symptoms recurred in four women. Six (35.2%) recurrences of endometrioma were noted with ultrasound control after 3, 6, and 12 months postoperatively. Endometrioid detritus in the cyst capsule was not detected in 64.8% of cases.</p> <p><bold>CONCLUSION</bold>: Preliminary results indicates the use of sclerotherapy by transvaginal access with ultrasound control for the treatment of endometriomas in women of reproductive age and patients planning pregnancy by ART with any level of ovarian reserve and recurrent, previously histologically confirmed, symptomatic endometriomas in women of reproductive age with no plans for pregnancy presently with a reduced ovarian reserve (AMH &lt;1.2 ng/ml) and with any level of ovarian reserve but with symptomatic endometrioma in the preserved ovary. Transvaginal access is applicable for symptomatic endometriomas in women who had undergone several operations in the past.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование</bold>. Аспирационно-пункционная склеротерапия является эффективным и безопасным методом хирургического лечения эндометриоидных кист яичников. Деструкция капсулы 95% этанолом позволяет минимально воздействовать на фолликулярный аппарат яичника. Методика требует тщательной оценки для возможности более частого применения на практике.</p> <p><bold>Цель</bold>. Определение показаний для применения методики аспирационно-пункционной склеротерапии трансвагинальным доступом в хирургическом лечении эндометриом яичников.</p> <p><bold>Материал и методы</bold>. С октября 2021 г. по октябрь 2023 г. на базе Московского областного научно-исследовательского института акушерства и гинекологии им. акад. В.И. Краснопольского 17 пациенткам в качестве лечения эндометриом яичников провели аспирационно-пункционную склеротерапию. Доминантными жалобами при поступлении в стационар являлись хроническая тазовая боль, наиболее часто обостряющаяся в середине менструального цикла (76,4%), дисменорея (82,3%), диспареуния (47,0%), кишечные жалобы (35,3% — в основном частый жидкий стул в дни менструации), полименорея (47,0%). Репродуктивные планы имели 13 из 17 женщин. У 11 (64,7%) пациенток зарегистрировано бесплодие. Ранее по поводу эндометриоза яичников были оперированы 11 пациенток.</p> <p><bold>Результаты</bold>. Анализ динамики уровня антимюллерова гормона (АМГ) до и после операции показал его незначительное снижение (средняя разница до и после оперативного лечения составила 0,47 нг/мл). Среднее число антральных фолликулов в обоих яичниках при сонографии до операции составило 10,8, после операции выявлено его снижение до 8,6. Отмечено снижение объёма яичника после проведённого склерозирования эндометриомы от 2 до 6 раз. Возобновление симптоматики отмечено у 4 пациенток. При наблюдении через 3, 6 и 12 мес. после оперативного лечения при контрольной сонографии эндометриомы сохранялись в 6 (35,2%) случаях. Отсутствие эндометриоидного детрита в просвете капсулы кисты выявлено у 64,8% пациенток.</p> <p><bold>Заключение</bold>. Предварительные результаты исследования позволяют выделить следующие категории пациенток, которым может быть рекомендована аспирационно-пункционная склеротерапия трансвагинальным доступом под контролем УЗИ в качестве хирургического лечения эндометриом яичников: пациентки репродуктивного возраста с любым уровнем овариального резерва, планирующие беременность при помощи вспомогательных репродуктивных технологий; пациентки репродуктивного возраста со сниженным овариальным резервом (АМГ &lt;1,2 нг/мл), не планирующие беременность в ближайшее время, с симптомными рецидивирующими, ранее гистологически подтверждёнными эндометриоидными кистами; пациентки с любым овариальным резервом, но с наличием симптомной эндометриомы в единственном сохранённом яичнике; пациентки без репродуктивных планов с симптомными эндометриомами и с осложнённым хирургическим анамнезом.</p></trans-abstract><trans-abstract xml:lang="zh"><p>论证。抽吸穿刺硬化疗法是手术治疗子宫内膜样卵巢囊肿的一种有效而安全的方法。用95%的乙醇破坏囊肿对卵巢的卵泡器影响最小。该方法需要仔细评估，以便在实践中更频繁地使用。</p> <p>目的。确定经阴道穿刺抽吸硬化疗法在卵巢子宫内膜手术治疗中的适应症。</p> <p>材料和方法。2021年10月至2023年10月期间，17名患者在 V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology 接受了抽吸穿刺硬化疗法，以治疗卵巢子宫内膜瘤。入院时的主要主诉是慢性盆腔疼痛，最常见的是在月经周期中期加重（76.4%）、痛经（82.3%）、性交困难（47.0%）、肠道不适（35.3%的人在月经日经常大便呈液体状）和多发性痛经（47.0%）。17 名妇女中有 13 人有生育计划。11名患者（64.7%）患有不孕症。此前，11名患者曾接受过卵巢子宫内膜异位症手术。</p> <p>结果。手术前后抗苗勒氏激素水平动态分析显示其略有下降（手术治疗前后的平均差异为 0.47 ng/mL）。手术前，超声检查显示双侧卵巢前卵泡的平均数量为 10.8 个，手术后降至 8.6 个。子宫内膜异位症硬化后，卵巢体积减少了2至6倍。有4名患者的症状再次出现。在手术治疗后 3 个月、6 个月和 12 个月的随访中，有 6 例（35.2%）患者的子宫内膜异位症在超声波检查中仍然存在。64.8%的患者在囊肿腔内未发现子宫内膜异位症残留物。</p> <p>结论。该研究的初步结果使我们能够确定以下类别的患者，这些患者可能会被建议在超声引导下经阴道穿刺抽吸硬化治疗作为卵巢子宫内膜的手术治疗：育龄期患者，卵巢有任何程度的储备功能，计划在辅助生殖技术的帮助下怀孕；育龄患者，卵巢储备功能减退（抗苗勒氏管激素＜1.2 ng/mL），近期内无怀孕计划，有症状的复发性子宫内膜样囊肿，既往经组织学证实； 有任何卵巢储备功能，但在唯一保留的卵巢中患有症状性子宫内膜瘤的患者；无生育计划，患有症状性子宫内膜瘤且手术史复杂的患者。</p></trans-abstract><kwd-group xml:lang="en"><kwd>endometrioma</kwd><kwd>infertility</kwd><kwd>surgical treatment of endometriomas</kwd><kwd>assisted reproductive technology</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>эндометриома</kwd><kwd>бесплодие</kwd><kwd>хирургическое лечение эндометриом</kwd><kwd>вспомогательные репродуктивные технологии</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>子宫内膜瘤</kwd><kwd>不孕症</kwd><kwd>子宫内膜瘤的手术治疗</kwd><kwd>辅助生殖技术</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Chen Y, Pei H, Chang Y, et al. 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