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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Архив акушерства и гинекологии им. В.Ф. Снегирева</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-8726</issn><issn publication-format="electronic">2687-1386</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">628310</article-id><article-id pub-id-type="doi">10.17816/aog628310</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">New therapeutic approaches for improving the outcomes of assisted reproductive technologies</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности новых терапевтических подходов, направленных на улучшение исходов вспомогательных репродуктивных технологий</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>旨在改善辅助生殖技术成果的新治疗方法的机遇</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4591-838X</contrib-id><contrib-id contrib-id-type="spin">5253-2836</contrib-id><name-alternatives><name xml:lang="en"><surname>Levakov</surname><given-names>Sergey A.</given-names></name><name xml:lang="ru"><surname>Леваков</surname><given-names>Сергей Александрович</given-names></name><name xml:lang="zh"><surname>Levakov</surname><given-names>Sergey A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>levakoff@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6104-9842</contrib-id><contrib-id contrib-id-type="spin">5122-4896</contrib-id><name-alternatives><name xml:lang="en"><surname>Gromova</surname><given-names>Tatyana A.</given-names></name><name xml:lang="ru"><surname>Громова</surname><given-names>Татьяна Александровна</given-names></name><name xml:lang="zh"><surname>Gromova</surname><given-names>Tatyana A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Assistant of the Department</p></bio><bio xml:lang="ru"><p>канд. мед. наук, ассистент кафедры</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine), Assistant of the Department</p></bio><email>tgromova928@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-9475-279X</contrib-id><contrib-id contrib-id-type="spin">1255-4654</contrib-id><name-alternatives><name xml:lang="en"><surname>Rudiakova</surname><given-names>Elizaveta A.</given-names></name><name xml:lang="ru"><surname>Рудякова</surname><given-names>Елизавета Александровна</given-names></name><name xml:lang="zh"><surname>Rudiakova</surname><given-names>Elizaveta A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>5<sup>th</sup> year student</p></bio><bio xml:lang="ru"><p>студентка 5-го курса</p></bio><bio xml:lang="zh"><p>5<sup>th</sup> year student</p></bio><email>doc.rudyakova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет им. И.М. Сеченова</institution></aff><aff><institution xml:lang="zh">I.M. Sechenov First Moscow State Medical University</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-09-09" publication-format="electronic"><day>09</day><month>09</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-10-07" publication-format="electronic"><day>07</day><month>10</month><year>2024</year></pub-date><volume>11</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>255</fpage><lpage>266</lpage><history><date date-type="received" iso-8601-date="2024-03-04"><day>04</day><month>03</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-04-15"><day>15</day><month>04</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2024,</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2026-10-07"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://archivog.com/2313-8726/article/view/628310">https://archivog.com/2313-8726/article/view/628310</self-uri><abstract xml:lang="en"><p>Infertility is a global health problem that affects up to 17.5% of the world’s population. The use of assisted reproductive technologies makes it possible to solve this problem; however, it is not adequately efficient in all observed cases. Implantation failure remains a serious and multifaceted problem faced by clinicians in reproductive technology, despite the significant advances that have been made in this area. This review highlights promising studies on medical and invasive intervention methods and their possible combinations, which potentially improve the clinical treatment of implantation failures. Nevertheless, further study is required to assess the effectiveness and safety of each therapeutic approach, which can introduce new prospects in the treatment of infertility and increase the chances of successful implantation and pregnancy.</p></abstract><trans-abstract xml:lang="ru"><p>Бесплодие представляет собой глобальную проблему здравоохранения, которая затрагивает до 17,5% населения во всем мире. Использование методов вспомогательных репродуктивных технологий помогает решать данную проблему, однако не обладает достаточной эффективностью во многих наблюдаемых случаях. Неудача имплантации представляет собой серьёзную и многогранную задачу, с которой сталкиваются специалисты репродуктивных технологий, несмотря на значительные успехи, достигнутые в данной области. В представленном обзоре освещаются перспективные исследования, основанные на медикаментозных и инвазивных методах вмешательств, а также их возможные комбинации, которые потенциально смогут улучшить клиническое лечение неудач имплантации. Тем не менее требуется дальнейшее изучение эффективности и безопасности каждого терапевтического подхода, которое сможет открыть новые перспективы в лечении бесплодия и повышении шансов на успешную имплантацию и беременность.</p></trans-abstract><trans-abstract xml:lang="zh"><p>不孕不育是一个全球性的健康问题，影响着全球高达17.5%的人口。辅助生殖技术的使用有助于解决这一问题，但在许多观察到的病例中效果并不理想。尽管生殖技术领域取得了重大进展，但植入失败仍是生殖技术专家面临的一个多方面的严峻挑战。这篇综述强调了基于药物和侵入性干预的前瞻性研究，以及它们可能的组合，有可能改善植入失败的临床治疗。然而，还需要进一步研究每种治疗方法的有效性和安全性，这将为不孕症的治疗开辟新的前景，并增加成功植入和怀孕的机会。</p></trans-abstract><kwd-group xml:lang="en"><kwd>implantation failures</kwd><kwd>assisted reproductive technologies</kwd><kwd>new therapy approaches</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>неудачи имплантации</kwd><kwd>вспомогательные репродуктивные технологии</kwd><kwd>новые подходы терапии</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>植入失败</kwd><kwd>辅助生殖技术</kwd><kwd>新治疗方法</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Wei D, Liu JY, Sun Y, et al. 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