<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Архив акушерства и гинекологии им. В.Ф. Снегирева</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-8726</issn><issn publication-format="electronic">2687-1386</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">44837</article-id><article-id pub-id-type="doi">10.17816/2313-8726-2020-7-3-120-123</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Chronic endometritis and its impact on female reproductive function</article-title><trans-title-group xml:lang="ru"><trans-title>Хронический эндометрит и его влияние на репродуктивную функцию женщины</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6454-1963</contrib-id><contrib-id contrib-id-type="scopus">504021</contrib-id><contrib-id contrib-id-type="spin">2342-3129</contrib-id><name-alternatives><name xml:lang="en"><surname>Silkina</surname><given-names>Marina O.</given-names></name><name xml:lang="ru"><surname>Силькина</surname><given-names>Марина Олеговна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>VI-year student of the Medical Faculty No 1 of the I.M. Sechenov First Moscow State Medical University (Sechenov University)</p></bio><bio xml:lang="ru"><p>студентка VI курса лечебного факультета ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)</p></bio><email>mari5555@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1732-6870</contrib-id><contrib-id contrib-id-type="spin">6313-9959</contrib-id><name-alternatives><name xml:lang="en"><surname>Sosnova</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Соснова</surname><given-names>Елена Алексеевна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD, Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>sosnova-elena@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет) Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-09-23" publication-format="electronic"><day>23</day><month>09</month><year>2020</year></pub-date><volume>7</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>120</fpage><lpage>123</lpage><history><date date-type="received" iso-8601-date="2020-09-22"><day>22</day><month>09</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-09-22"><day>22</day><month>09</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ООО "Эко-Вектор"</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://archivog.com/2313-8726/article/view/44837">https://archivog.com/2313-8726/article/view/44837</self-uri><abstract xml:lang="en"><p><italic>Chronic endometritis is a local inflammatory disease characterized by the presence of plasma cells in endometrial stroma regardless of menstrual cycle phase. This diagnosis can be confirmed based only on morphological examination of endometrial biopsy what makes this diagnosis difficult to prove in clinically healthy patients who can not get pregnant or carry a child. According to statistics of the past five years, more than 30% women of reproductive age having repeated implantation failures in IVF cycles and recurrent miscarriages are diagnosed with chronic endometritis. Since this pathology is related to long persistence of microbial associations in uterine cavity, the gold standard of treatment is antibacterial therapy. It is elucidated that during a year after antibiotic treatment the rate of spontaneous pregnancy is increased in more than 60% women compared with women who do not receive treatment regarding chronic endometritis.</italic></p></abstract><trans-abstract xml:lang="ru"><p>Хронический эндометрит — локальное воспалительное заболевание, характеризующееся наличием плазматических клеток в строме эндометрия независимо от фазы менструального цикла. Этот диагноз можно подтвердить только на основании морфологического исследования биоптата эндометрия, что затрудняет постановку диагноза у клинически здоровых пациенток, неспособных забеременеть или выносить ребёнка. По статистике за последние пять лет, более чем у 30% женщин репродуктивного возраста с повторными неудачами имплантации в циклах экстракорпорального оплодотворения (ЭКО) и рецидивирующими выкидышами диагностируют хронический эндометрит. Поскольку эта патология связана с длительной персистенцией микробных ассоциаций в полости матки, то «золотым стандартом» лечения является антибактериальная терапия. Установлено, что в течение года после антибиотикотерапии более чем у 60% женщин увеличивается показатель наступления спонтанной беременности по сравнению с женщинами, не получающими лечение по поводу хронического эндометрита.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chronic endometritis</kwd><kwd>repeated implantation failure</kwd><kwd>recurrent miscarriage</kwd><kwd>antibiotic treatment</kwd><kwd>pregnancy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хронический эндометрит</kwd><kwd>повторные неудачи имплантации</kwd><kwd>рецидивирующий выкидыш</kwd><kwd>антибиотикотерапия</kwd><kwd>беременность</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kitaya K., Matsubayashi H., Yamaguchi K., Nishiyama R., Takaya Y., Ishikawa T. et al. Chronic Endometritis: Potential Cause of Infertility and Obstetric and Neonatal Complications. Am. J. Reprod. Immunol. 2015;75(1):13-22.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kitaya K., Takeuchi T., Mizuta S., Matsubayashi H., Ishikawa T. Endometritis: new time, new concepts. Fertil. Steril. 2018;110(3): 344-50.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Park H.J., Kim Y.S., Yoon T.K., Lee W.S. Chronic endometritis and infertility. Clin. Experim. Reprod. Med. 2016;43(4):185.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Kimura F., Takebayashi A., Ishida M., Nakamura A., Kitazawa J., Morimune A. et al. Chronic endometritis and its effect on reproduction. Review. J. Obstet. Gynaecol. Res. 2019;45(5):951-60.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Cicinelli E., Matteo M., Trojano G., Mitola P. C., Tinelli R., Vitagliano A. et al. Chronic endometritis in patients with unexplained infertility: Prevalence and effects of antibiotic treatment on spontaneous conception. Am. J. Reprod. Immunol. 2017;79(1):e12782.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Koninckx P.R., Ussia A., Tahlak M., Adamyan L., Wattiez A., Martin D.C., Gomel V. Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review. Facts Views Vis. Obgyn. 2019;11(3):209-16.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Толибова Г.Х. Эндометриальная дисфункция у женщин с бесплодием: патогенетические детерминанты и клинико-морфологическая диагностика: Дисс. ... д-ра мед. наук. СПб.; 2018./Tolibova G.Kh. Endometrial dysfunction in women with infertility: pathogenetic determinants and clinical and morphological diagnostics: Diss. Saint Petersburg; 2018. (In Russ.)</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Lucas E.S., Dyer N.P., Murakami K., Hou Lee Y., Chan Y.-W., Grimaldi G. et al. Loss of endometrial plasticity in recurrent pregnancy loss. Stem Cells. 2015;34(2):346-56.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>McQueen D.B., Perfetto C.O., Hazard F.K., Lathi R.B. Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss. Fertil. Steril. 2015;104(4):927-31.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Cicinelli E., Matteo M., Tinelli R., Lepera A., Alfonso R., Indraccolo U. et al. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum. Reprod. 2015;30(2):323-30.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Johnston-MacAnanny E.B., Hartnett J., Engmann L.L., Nulsen J.C., Sanders M.M., Benadiva C.A. Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization. Fertil. Steril. 2010;93(2):437-41.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Vitagliano A., Saccardi C., Noventa M., Di Spiezio Sardo A., Saccone G., Cicinelli E. et al. Effects of chronic endometritis therapy on in vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis. Fertil. Steril. 2018; 110(1):103-12.e1.</mixed-citation></ref></ref-list></back></article>
