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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">V.F.Snegirev Archives of Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Архив акушерства и гинекологии им. В.Ф. Снегирева</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-8726</issn><issn publication-format="electronic">2687-1386</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">42999</article-id><article-id pub-id-type="doi">10.18821/2313-8726-2019-6-2-73-79</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original study articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Original study articles</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">ACTUAL VIEW ON THE VITAMIN D EFFECT ON WOMEN’S HEALTH</article-title><trans-title-group xml:lang="ru"><trans-title>СОВРЕМЕННЫЙ ВЗГЛЯД НА ВЛИЯНИЕ ВИТАМИНА D НА ЗДОРОВЬЕ ЖЕНЩИНЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Savchenko</surname><given-names>T. N</given-names></name><name xml:lang="ru"><surname>Савченко</surname><given-names>Т. Н</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dergacheva</surname><given-names>I. A</given-names></name><name xml:lang="ru"><surname>Дергачёва</surname><given-names>И. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ozolinya</surname><given-names>Lyudmila A.</given-names></name><name xml:lang="ru"><surname>Озолиня</surname><given-names>Людмила Анатольевна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, Ph.D., DSci., Professor of the Department of Obstetrics and Gynecology, Medical Faculty of the N.I. Pirogov Russian National Research Medical University, 117007, Moscow, Russian Federation</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф. кафедры акушерства и гинекологии лечебного факультета ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, 117007, г. Москва</p></bio><email>ozolinya@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2019</year></pub-date><volume>6</volume><issue>2</issue><issue-title xml:lang="en">VOL 6, NO2 (2019)</issue-title><issue-title xml:lang="ru">ТОМ 6, №2 (2019)</issue-title><fpage>73</fpage><lpage>79</lpage><history><date date-type="received" iso-8601-date="2020-08-24"><day>24</day><month>08</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, ООО "Эко-Вектор"</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://archivog.com/2313-8726/article/view/42999">https://archivog.com/2313-8726/article/view/42999</self-uri><abstract xml:lang="en"><p>According to last research, receptors for vitamin D are found in many organs and tissues. Vitamin D deficiency leads to the development of pathological conditions in children and adults. The non-classical effects of vitamin D are important in modulating congenital and acquired immunity, regulating cell proliferation, in the progress of diabetes, the pathology of the cardiovascular system, and autoimmune diseases. The inverse correlation between the level of 25(OH)D3 and the incidence of cancer has been determined. Vitamin D affects the course of pregnancy, and the decidual and placental tissues synthesize 1.25(OH)2D. Vitamin deficiency is found in pregnant women with preeclampsia and gestational diabetes. Timely diagnosis and adequate correction of the level of vitamin D in the blood reduces the risk of developing diseases.</p></abstract><trans-abstract xml:lang="ru"><p>Согласно данным современных исследований, рецепторы к витамину D находятся во многих органах и тканях. При недостаточности витамина D развиваются патологические состояния не только у детей первого года жизни (рахит), но и у взрослых. Неклассические действия витамина D имеют значение в модуляции врождённого и приобретённого иммунитета, регуляции клеточной пролиферации, патологии сердечно-сосудистой системы, развитии сахарного диабета, аутоиммунных заболеваний. Установлена обратная корреляция уровня кальцидиола 25(OH)D3 и частоты возникновения онкологических заболеваний. Витамин D оказывает влияние на развитие беременности, а децидуальная и плацентарные ткани также синтезируют 1,25(ОН)2D. Недостаточность витамина D обнаружена у беременных с преэклампсией и гестационным сахарным диабетом. Своевременная диагностика и адекватная коррекция уровня витамина D в крови снижает риск развития заболеваний.</p></trans-abstract><kwd-group xml:lang="en"><kwd>vitamin D</kwd><kwd>vitamin D metabolites</kwd><kwd>vitamin D deficiency</kwd><kwd>immunity</kwd><kwd>pregnancy pathology</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>витамин D</kwd><kwd>метаболиты витамина D</kwd><kwd>дефицит витамина D</kwd><kwd>иммунитет</kwd><kwd>патология беременности</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Simpson R.U., Thomas G.A., Arnold A.J. Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J. Biol. Chem. 1985; 25 (260): 8882-91.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Simpson R.U., Bone H.G. Vitamin D and cardiovascular disease. Pharmacotherapy. 2009; 29 (6): 691-708.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>On behalf of the European Society for Paediatric Endocrinology (ESPE) Bone Club. Consensus development for the supplementation of vitamin D in childhood and adolescence. Horm. Res. 2002; 58: 39-51.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Holick M.F. Vitamin D and healht: evolution, biologic, functions, and recommended dietary intakes for vitamin D. Clinic Rev. Bone. Miner. Metab. 2009; 7: 2-19.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Hochberg Z., ed. Vitamin D and Rickets. Endocrine Development. Basel: Karger; 2003: vol. 6: 259-81.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Holick M.F. Resurrection of vitamin D deficiency and rickets. J. Clin. Invest. 2006. 116 (8): 2062-72.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Спиричев В.Б. О биологических эффектах витамина D. Педиатрия. 2011; 90 (6): 113-9.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Милотова Н.М. Роль полиморфизма гена VDR, кодирующего рецепторы витамина D, в патогенезе артериальной гипертензии. Биомедицина. 2009; 1 (1): 55-67.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Hossein-nezhad A., Holick M.F. Vitamin D for health: global perspective. Mayo Clin. Proc. 2013; 88(7): 720-55</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Дедов И.И., Мельниченко Г.А. Дефицит витамина D: диагностика, лечение и профилактика. М.; 2014.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Беневоленская Л.И., ред. Остеопороз. Диагностика, профилактика и лечение. Клинические рекомендации. М.: ГЭОТАР-Медиа; 2009.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Khoo A.L., Chai L., Koenen H., Joosten I., Netea M., Van der Ven A. Translating the role of vitamin D3 in infectious diseases. Crit. Rev. Microbiol. 2012; 38(2): 122-35</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Снопов С.А. Механизмы действия витамина D на иммунную систему. Медицинская иммунология. 2014; 16 (6): 499-530.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Абатуров А.Е., Завгородняя Н.Ю. Витамин-D-зависимая продукция антимикробных пептидов. Здоровье ребёнка. 2012; 1(36): 105-11.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Bischoff H.A., Stahelin H.B., Dick W. et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J. Bone Miner. Res. 2003;18: 343-51.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Cantorna M.T. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory boweldisease. Prog. Biophys. Mol. Biol. 2006; 92: 60-4.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Бабик А.И., Каледина Е.А. Витамин D, кальций и рак молочной железы. Медицинские аспекты здоровья женщины. 2009; 5(22): 1-8</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Barry M.J., De Vries E., English D., Giovannucci E. et al. Vitamin D and Cancer. IARC 2008. World health organization. International Agency for Research on Cancer. Working Group Reports. 2008; 5.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Kienreich K., Grübler M., Tomaschitz A., Schmid J., Verheyen N., Rutters F. et al. Vitamin D, arterial hypertension &amp; cerebrovascular disease. Indian J. Med. Res. 2013; 137: 669-79.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Jørgensen S.P., Agnholt J., Glerup H. Clinical trial: vitamin D3 treatment in Crohn’s disease - a randomized double-blind placebo-controlled study. Alimentary Pharmacology &amp; Therapeutics. 2010; 32 (3): 377-83.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Holick M.F. Vitamin D deficiency. N. Engl. J. Med. 2007; 357: 266-81.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Cannell J., Hollis B. Use of vitamin D in clinical practice. Altern. Med. Rev. 2008; 13 (1): 6-20.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Bikle D. Vitamin D and immune function: understanding common pathways. Curr. Osteoporos. Rep. 2009; 7: 58-63.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Мальцев С.В., Мансурова Г.Ш. Метаболизм витамина D и пути реализации его основных функций. Практическая медицина. 2014; (9): 12-8</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Arora Ch.P., Hobel C.J.1. Vitamin D - a novel role in pregnancy. Biopolymers and Cell. 2010; 26 (2): 97-104</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Щеплягина Л.А. Программирование развития скелета у детей: роль витамина D. Остеопороз и остеопатии. 2014; (3): 31-3.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Щеплягина Л.А., Крутикова Н.Ю., Моисеева Т.Ю. и др. Состояние костного метаболизма и линейный рост младенцев в зависимости от обеспеченности матери кальцием. Вопросы современной педиатрии. 2006; 5 (5): 86-9.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Zhang C., Qiu C., Hu F.B., David R.M., van Dam R.M., Bralley A., et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. Plos One. 2008; 3: e3753.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Stene L.C., Ulriksen J., Magnus P., Joner G. Use of cod liver oil during pregnancy associated with lower risk of type I diabetes in the offspring. Diabetologia. 2000; 43: 1093e8.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Robinson C.J., Alanis M.C., Wagner C.L., Hollis B.W., Jonson D.D. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am. J. Ob. Gyn. 2010; 203(4): 366.e1-6.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Kovacs C.S., Kronenberg H.M. Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr. Rev. 1997; 18: 832e72.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Haugen M., Brantsaeter A.L., Trogstad L. et al. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology. 2009; 20: 720e6.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Щеплягина Л.А. Антенатальная профилактика рахита. Лечение и профилактика. 2013; 2(6): 7-12.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Мальцева Л.И., Васильева Э.Н. Новые подходы к оценке роли витамина D в репродуктивном здоровье женщины. Практическая медицина. 2013; 7(76): 42-7.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Weisman Y. Non-classic unexpected functions of vitamin D. Pediatr. Endocrinol. Rev. 2010; 8(2): 103-7.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Schwalfenberg G.K. A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Mol. Nutr. Food Res. 2011; 55 (1): 96-108.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Bartley J. Vitamin D, innate immunity and upper respiratory tract infection. J. Laryngol. Otol. 2010; 124(5): 465-9.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Руснак Ф.И. Витамин D и прогрессирование заболеваний почек. Вестник научно-технического развития. 2009; (11): 52-64</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Litwack G., ed. Vitamins and the Immune System. 1st Ed. Vol. 86. Academic Press; 2011</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Ковальчук Л.В., Свитич О.А., Ганковская Л.В., Мирошниченкова А.М., Ганковский В.А. Роль Toll-подобных рецепторов в патогенезе инфекционных заболеваний человека. Курский научно-практический вестник «Человек и его здоровье». 2012; (2): 147-53</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Talat N., Perry S., Parsonnet J., Dawood G., Hussain R. Vitamin D Deficiency and Tuberculosis Progression. Emerginfectdis. 2010; 16(5): 853-5.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Jahnsen J., Falch J.A., Mowinckel P., Aadland E. Vitamin D status, parathyroid hormone and bone mineral density in patients with inflammatory bowel disease. Scand. J. Gastroenterol. 2002; 37: 192-9.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Bodnar L.M., Krohn M.A., Simhan H.N. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J. Nutr. 2009; 139: 1157e61.</mixed-citation></ref></ref-list></back></article>
