V.F.Snegirev Archives of Obstetrics and GynecologyV.F.Snegirev Archives of Obstetrics and Gynecology2313-87262687-1386Eco-Vector35265Research ArticleAngiogenic growth factors in the pathogenesis of pre-eclampsiaMurashkoA. Vmurashkoa@mail.ruFaizullinA. L-MurashkoL. E-I.M. Sechenov First Moscow State Medical UniversityV.I. Kulakov Center of Obstetrics, Gynecology, and Perinatology15092015234721072020Copyright © 2015, Eco-Vector2015The pathogenetic mechanisms of pre-eclampsia are reviewed, modern risk factors are described, and probable consequences for the mother during the postpartum period and for the fetus in postnatal life are discussed.pre-eclampsiaangiogenic growth factorsпреэклампсияангиогенные факторы роста[Brown M. et al. The classifi cation and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertension in pregnancy: offi cial journal of the International Society for the Study of Hypertension in Pregnancy. 2001: IX-XIV.][Steegers E.A.P. et al. Pre-eclampsia. Lancet. 2010; 376 (9741): 631-44.][Young B.C., Levine R.J., Karumanchi S.A. Pathogenesis of preeclampsia. Ann. Rev. Pathol. 2010; 5: 173-92.][Granger J.P. et al. Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia. Methods Mol. Med. 2006; 122: 383-92.][Makris A. et al. Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1. Kidney Int. 2007; 71 (10): 977-84.][Chaiworapongsa T. et al. Pre-eclampsia part 1: current understanding of its pathophysiology. Nat. Rev. Nephrol. 2014; 10 (8): 466-80.][Naljayan M. V., Karumanchi S.A. New Developments in the Pathogenesis of Preeclampsia. Adv. Chronic Kidney Dis. 2013; 20 (3): 265-270.][Levine R.J. et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N. Engl. J. Med. 2006; 355 (10): 992-1005.][Conti E. et al. Growth factors in preeclampsia: A vascular disease model: A failed vasodilation and angiogenic challenge from pregnancy onwards? Cytokine Growth Factor Rev. 2013; 24 (5): 411-25.][Verlohren S., Stepan H., Dechend R. Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia. Clin. Sci. 2011; 122(2): 43-52.][Lassus P. et al. Vascular endothelial growth factor and angiogenin levels during fetal development and in maternal diabetes. Biol. Neonate. 2003; 84 (4): 287-92.][Kleinrouweler C.E. et al. Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: A systematic review and meta-analysis. BJOG An Int. J. Obstetr. Gynaecol. 2012; 119 (7): 778-87.][Espinoza J. et al. Identifi cation of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor. Am. J. Obstet. Gynecol. 2007; 196 (4): 326.e1-326.13.][Levine R.J. et al. Circulating angiogenic factors and the risk of preeclampsia. N. Engl. J. Med. 2004; 350 (7): 672-83.][Maynard S.E. et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 2003; 111 (5): 649-58.][Shibuya M. Vascular endothelial growth factor and its receptor system: Physiological functions in angiogenesis and pathological roles in various diseases. J. Biochem. 2013; 153 (1): 13-9.][Romero R. et al. An imbalance between angiogenic and anti-angiogenic factors precedes fetal death in a subset of patients: results of a longitudinal study. J. Matern. Fetal. Neonatal Med. 2010; 23 (12): 1384-99.][Akolekar R. et al. Maternal plasma soluble fms-like tyrosine kinase-1 and free vascular endothelial growth factor at 11 to 13 weeks of gestation in preeclampsia. Prenat. Diagn. 2010; 30 (3): 191-7.][Foidart J.M. et al. Dysregulation of anti-angiogenic agents (sFlt-1, PLGF, and sEndoglin) in preeclampsia-a step forward but not the defi nitive answer. J. Reprod. Immunol. 2009; 82 (2): 105-10.][Kusanovic J. P., Romero R., Chaiworapongsa T., Erez O. et al. A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identifi cation of patients destined to develop preeclampsia. J. Matern. Fetal Neonatal Med. 2009; 22: 1021-38.][Munaut C. et al. Differential expression of Vegfr-2 and its soluble form in preeclampsia. PLoS One. 2012; 7 (3): e33475.][Powe C.E., Levine R.J., Karumanchi S.A. Preeclampsia, a disease of the maternal endothelium: The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 2011; 123(24): 2856-69.][Wada Y. et al. Effects of KRN633, an inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase, on vascular development of placenta and fetus of mid-pregnancy in mice. J. Pharmacol. Sci. 2010; 112 (3): 290-8.][Levine R.J. et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N. Engl. J. Med. 2006; 355 (10): 992-1005.][Venkatesha S. et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat. Med. 2006; 12 (6): 642-9.][Mutter W.P., Karumanchi S.A. Molecular mechanisms of preeclampsia. Microvasc. Res. 2008; 75 (1): 1-8.][Perni U. et al. Angiogenic factors in superimposed preeclampsia: A longitudinal study of women with chronic hypertension during pregnancy. Hypertension. 2012; 59 (3): 740-6.][Lai J. et al. Maternal serum soluble endoglin at 30-33 weeks in the prediction of preeclampsia. Fetal Diagn. Ther. 2013; 33 (3): 149-55.][Gaber K., Hamdy E., Hanafy A. Soluble Endoglin as a new marker for prediction of pre-eclampsia in early pregnancy. Middle East Fertil. Soc. J. 2010; 15 (1): 42-6.][Hermes W., Kesteren F. Van, De Groot C.J.M. Preeclampsia and cardiovascular risk. Minerva Ginecol. 2012; 64 (4): 281-92.][Chen C.W., Jaffe I.Z., Karumanchi S.A. Pre-eclampsia and cardiovascular disease. Cardiovasc. Res. 2014; 101 (4): 579-86.][Jayet P.Y. et al. Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia. Circulation. 2010; 122 (5): 488-94.][Eremina V., Jefferson J.A., Kowalewska J., Hochster H. et al. VEGF inhibition and renal thrombotic microangiopathy. N. Engl. J. Med. 2008; 358 (11): 1129-36.][Spaan J.J. et al. Renal function after preeclampsia: A longitudinal pilot study. Nephron-Clin. Pract. 2012; 120 (3): 156-61.][McDonald S.D. et al. Kidney Disease After Preeclampsia: A Systematic Review and Meta-analysis. Am. J. Kidney Dis. 2010; 55 (6): 1026-39.]